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Protein Overview: NR4A2_RAT

General Information:
Name(s) found: NR4A2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6166579|sp|Q07917.3|NR4A2_RAT RecName: Full=Nuclear receptor subfamily 4 group A member 2; AltName: Full=Orphan nuclear receptor NURR1; AltName: Full=NUR-related factor 1; AltName: Full=Regenerating liver nuclear receptor 1; Short=RNR-1; AltName: Full= [NCBI NR]
  • Nuclear receptor subfamily 4 group A member 2 OS=Rattus norvegicus GN=Nr4a2 PE=1 SV=3 [Swiss-Prot]
  • (Q07917) Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR-related factor 1) (Regenerating liver nuclear receptor 1) (RNR-1) (SL-322) (Nuclear orphan receptor HZF-3) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):3-34684787;3-34684787;3-34684787 Orphan nuclear receptor NURR1 [hmr_yeast5_DM3-1_pombe.fasta]
  • Orphan nuclear receptor NURR1 (NUR-related factor 1) (Regenerating liver nuclear receptor 1) (RNR-1) (SL-322) (Nuclear orphan receptor HZF-3) [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Orphan nuclear receptor NR4A2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Nuclear receptor subfamily 4 group A member 2 (Orphan nuclear receptor NURR1) (NUR-related factor 1) (Regenerating liver nuclear receptor 1) (RNR-1) (SL-322) (Nuclear orphan receptor HZF-3) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 ORPHAN NUCLEAR RECEPTOR NR4A2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR-related factor 1) (Regenerating liver nuclear receptor 1) (RNR-1) (SL-322) (Nuclear orphan receptor HZF-3) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Nr4a2 Nuclear receptor subfamily 4 group A member 2 [rat-ipi-250309-contam.fasta]
  • Nuclear receptor subfamily 4 group A member 2 OS=Rattus norvegicus GN=Nr4a2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 598 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    cytoplasm [IDA]
    Biological Process: dopamine biosynthetic process [UNKNOWN][IEA]
    dopamine metabolic process [UNKNOWN]
    post-embryonic development [UNKNOWN][IEA]
    nervous system development [UNKNOWN][IEA]
    central nervous system projection neuron axonogenesis [UNKNOWN][IEA]
    neuron maturation [UNKNOWN][IEA]
    adult locomotory behavior [UNKNOWN][IEA]
    central nervous system neuron differentiation [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    negative regulation of neuron apoptosis [UNKNOWN][IEA]
    neuron migration [UNKNOWN][IEA]
    response to hypoxia [UNKNOWN][IEA]
    response to insecticide [IDA]
    response to inorganic substance [IDA]
    response to protein stimulus [UNKNOWN][IEA]
    neuron differentiation [UNKNOWN]
    regulation of respiratory gaseous exchange [UNKNOWN][IEA]
    response to stress [UNKNOWN]
    regulation of transcription from RNA polymerase II promoter [TAS]
    cellular response to extracellular stimulus [UNKNOWN][IEA]
    response to amphetamine [UNKNOWN][IEA]
    positive regulation of catalytic activity [UNKNOWN][IEA]
    regulation of dopamine metabolic process [UNKNOWN][IEA]
    gene expression [UNKNOWN]
    death [UNKNOWN][IEA]
    Molecular Function: DNA binding [UNKNOWN][TAS]
    transcription factor activity [TAS]
    zinc ion binding [IEA]
    protein binding [IEA]
    ligand-dependent nuclear receptor activity [TAS]
    metal ion binding [IEA]
    protein heterodimerization activity [UNKNOWN][IEA]
    steroid hormone receptor activity [IEA]
    sequence-specific DNA binding [UNKNOWN][IDA]
    transcription activator activity [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF  60
   61 STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV 120
  121 YYKPSSPPTP STPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ 180
  181 SRPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA 240
  241 SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 300
  301 ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQDPSPPSP 360
  361 PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW 420
  421 AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG 480
  481 EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT 540
  541 FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle