Protein Overview: EPAS1_RAT

General Information:
Name(s) found:	EPAS1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|8953577\|emb\|CAB96612.1\| hypoxia inducible factor 2 alpha [Rattus norvegicus] [NCBI NR] gi\|32469610\|sp\|Q9JHS1.1\|EPAS1_RAT RecName: Full=Endothelial PAS domain-containing protein 1; Short=EPAS-1; AltName: Full=Hypoxia-inducible factor 2 alpha; Short=HIF-2 alpha; Short=HIF2 alpha [NCBI NR] gi\|12831205\|ref\|NP_075578.1\| endothelial PAS domain protein 1 [Rattus norvegicus] [NCBI NR] (Q9JHS1) Endothelial PAS domain protein 1 (EPAS-1) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) [Swiss-Prot] Endothelial PAS domain-containing protein 1 OS=Rattus norvegicus GN=Epas1 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Hypoxia inducible factor 2 alpha [hmr_yeast5_DM3-1_pombe.fasta] endothelial PAS domain protein 1 [HMR_022704-rand.fasta] endothelial PAS domain protein 1 [Rattus norvegicus]gi\|8953577\|emb\|CAB96612.1\| hypoxia inducible factor 2 alpha [Rattus norvegicus]gi\|32469610\|sp\|Q9JHS1\|PAS1_RAT Endothelial PAS domain protein 1 (EPAS-1) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Endothelial PAS domain-containing protein 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Endothelial PAS domain protein 1 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_023090) endothelial PAS domain protein 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] endothelial PAS domain protein 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] hypoxia inducible factor 2 alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 ENDOTHELIAL PAS DOMAIN PROTEIN 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Epas1 Endothelial PAS domain-containing protein 1 [rat-ipi-250309-contam.fasta] Endothelial PAS domain-containing protein 1 OS=Rattus norvegicus GN=Epas1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	874 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IDA] transcription factor complex [UNKNOWN][IDA][IEA] cytoplasm [UNKNOWN][IDA]
Biological Process:	norepinephrine metabolic process [UNKNOWN][IEA][IMP] transcription [IEA] regulation of transcription from RNA polymerase II promoter in response to oxidative stress [UNKNOWN][IDA][IEA][IGI][IMP] signal transduction [IEA] multicellular organismal development [IEA] hemopoiesis [UNKNOWN][IEA][IMP] regulation of transcription, DNA-dependent [IEA] cell maturation [UNKNOWN][IEA][IMP] visual perception [UNKNOWN][IEA][IMP] regulation of transcription [IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA][IGI][IMP] embryonic placenta development [UNKNOWN][IEA][IGI] mitochondrion organization [UNKNOWN][IEA][IMP] surfactant homeostasis [UNKNOWN][IEA][IMP] regulation of heart rate [UNKNOWN][IEA][IMP] response to oxidative stress [UNKNOWN][IEA][IGI][IMP] response to hypoxia [UNKNOWN][IDA][IMP][TAS] blood vessel remodeling [UNKNOWN][IEA][IMP] erythrocyte differentiation [UNKNOWN][IEA][IMP] angiogenesis [UNKNOWN][IEA][IMP] cell differentiation [UNKNOWN][IEA][IGI] lung development [UNKNOWN][IEA][IMP]
Molecular Function:	DNA binding [UNKNOWN][IDA][IGI] transcription factor activity [UNKNOWN][IDA] histone acetyltransferase binding [UNKNOWN][IEA] protein binding [UNKNOWN] transcription regulator activity [IEA] protein heterodimerization activity [UNKNOWN][IEA][IPI] specific RNA polymerase II transcription factor activity [UNKNOWN][IDA] sequence-specific DNA binding [UNKNOWN][IDA] transcription factor binding [UNKNOWN][IEA][IPI] signal transducer activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTADKEKKRS SSELRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA  60
   61 ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG 120
  121 LTQVELTGHS IFDFTHPCDH EEIRENLTLK TGSGFGKKNK DRSTERDFFM RMKCTVTNRG 180
  181 RTVNLKSATW KVLHCTGQVR VYNNCPPHSS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD 240
  241 SKTFLSRHSM DMKFTYCDDR ILELVGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG 300
  301 QVVSGQYRML AKHGGYVWLE TQGTVVYNPR NLQPQCIMCV NYVLSEIEKN DVVVSMDQTE 360
  361 SCSSHTLMAM NSIFDTSDDV ALSEKSNYLF TNLKEEPEDL AQLAPTPGDA IISLDFGSQN 420
  421 FDESSTYGKA ILPPGQPWAT ELRSHSAQSE SRSLPAFTVP QAGSPGNATP SATSSSSCST 480
  481 PSSPEDYYSS LENHLKIEVI EKLFAMDTEA KDQCSTQTDF NELDLETLAP YIPMDGEDFQ 540
  541 LSPICPEEPL VPESPQPNPQ HCFSTMSSIF QPLTPGASQG TFFLDKYPQQ LESRKTESEH 600
  601 WPMSTIFFDA GSKGSLPPCC GQASTPLSSM GGRSNTPWPP DPPLHLGPTK WSVGNQSAEP 660
  661 LGPLPLGTSQ LEPPSTPPHV SMFKMRSAKD FGARGPYMMS PAMIALSNKL KLKRQLDYEE 720
  721 PAFQDTSGGD PPGTSSSHLM WKRMKSLMGG TCPLMPDKTV SASMAPDEFT QKSMRGLGQP 780
  781 LRHLPPSQPP STRSPGENAK SGFPPQCYAS PFQDYSPPGA QKGSGVASRL LGPSFEPYLL 840
  841 PELTRYDCEV NVPEPGSSTL LQGRDLLRAL DQAT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: EPAS1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: