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Protein Overview: HPGDS_RAT

General Information:
Name(s) found: HPGDS_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6435744|pdb|1PD2|2 Chain 2, Crystal Structure Of Hematopoietic Prostaglandin D Synthase Complex With Glutathione [NCBI NR]
  • gi|6435743|pdb|1PD2|1 Chain 1, Crystal Structure Of Hematopoietic Prostaglandin D Synthase Complex With Glutathione [NCBI NR]
  • gi|6226954|sp|O35543.3|PTGD2_RAT RecName: Full=Glutathione-requiring prostaglandin D synthase; AltName: Full=Glutathione-dependent PGD synthetase; AltName: Full=Prostaglandin-H2 D-isomerase; AltName: Full=Hematopoietic prostaglandin D synthase; Short=H-PG [NCBI NR]
  • gi|56270580|gb|AAH87590.1| Prostaglandin D2 synthase 2, hematopoietic [Rattus norvegicus] [NCBI NR]
  • gi|2558505|dbj|BAA22898.1| hematopoietic prostaglandin D synthase [Rattus norvegicus] [NCBI NR]
  • gi|149037039|gb|EDL91600.1| prostaglandin D2 synthase 2, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13928888|ref|NP_113832.1| prostaglandin D2 synthase, hematopoietic [Rattus norvegicus] [NCBI NR]
  • Glutathione-requiring prostaglandin D synthase OS=Rattus norvegicus GN=Ptgds2 PE=1 SV=3 [Swiss-Prot]
  • Hematopoietic prostaglandin D synthase OS=Rattus norvegicus GN=Hpgds PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):4-98789633 prostaglandin D2 synthase 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • prostaglandin D2 synthase 2; prostaglandin D2 synthase 2, hematopoietic; prostaglandin D2 synthase 2 hematopoietic [HMR_022704-rand.fasta]
  • prostaglandin D2 synthase 2; prostaglandin D2 synthase 2 hematopoietic; prostaglandin D2 synthase 2, hematopoietic [071204_hmrz_cont.fasta]
  • prostaglandin D2 synthase 2 [Rattus norvegicus]gi|2558505|dbj|BAA22898.1| hematopoietic prostaglandin D synthase [Rattus norvegicus]gi|6226954|sp|O35543|PGD2_RAT Glutathione-requiring prostaglandin D synthase (Glutathione-dependent PGD synthetase) (Pros [nrdb_11152004_Chlamydomonas]
  • (NM_031644) prostaglandin D2 synthase 2; prostaglandin D2 synthase 2, hematopoietic [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Glutathione-requiring prostaglandin D synthase (Glutathione-dependent PGD synthetase) (Prostaglandin-H2 D-isomerase) (Hematopoietic prostaglandin D synthase) (H-PGDS) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Prostaglandin D2 synthase 2, hematopoietic [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • prostaglandin D2 synthase 2, hematopoietic [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Chain 2, Crystal Structure Of Hematopoietic Prostaglandin D Synthase Complex With Glutathione [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Chain 1, Crystal Structure Of Hematopoietic Prostaglandin D Synthase Complex With Glutathione [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • prostaglandin D2 synthase 2, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • hematopoietic prostaglandin D synthase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PROSTAGLANDIN D2 SYNTHASE 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Prostaglandin D2 synthase 2 [Rattus norvegicus] [nr-271106-contam.fasta]
  • prostaglandin D2 synthase 2 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Ptgds2 Glutathione-requiring prostaglandin D synthase [rat-ipi-250309-contam.fasta]
  • Hematopoietic prostaglandin D synthase OS=Rattus norvegicus GN=Hpgds [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 199 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: prostaglandin biosynthetic process [TAS]
    prostaglandin metabolic process [UNKNOWN]
    fatty acid biosynthetic process [IEA]
    Molecular Function: prostaglandin-D synthase activity [UNKNOWN][TAS]
    glutathione transferase activity [IEA]
    transferase activity [IEA]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNYKLLYFN MRGRAEIIRY IFAYLDIKYE DHRIEQADWP KIKPTLPFGK IPVLEVEGLT  60
   61 LHQSLAIARY LTKNTDLAGK TELEQCQVDA VVDTLDDFMS LFPWAEENQD LKERTFNDLL 120
  121 TRQAPHLLKD LDTYLGDKEW FIGNYVTWAD FYWDICSTTL LVLKPDLLGI YPRLVSLRNK 180
  181 VQAIPAISAW ILKRPQTKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] PSI-BLAST 35.30103 Class sigma GST

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glutathione transferase activity
    		•  4.50796867464992 bayes_pls_golite062009
  • prostaglandin-D synthase activity
    		•  3.77818075962089 bayes_pls_golite062009
  • glutathione binding
    		•  3.70571520983029 bayes_pls_golite062009
  • antioxidant activity
    		•  3.66884588063322 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • selenium binding
    		•  2.55069860113032 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.8187537496904 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.03696928411308 bayes_pls_golite062009
  • signal transducer activity
    		•  1.03696928411308 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • receptor binding
    		•  0.430107649265259 bayes_pls_golite062009
  • maleylacetoacetate isomerase activity
    		•  0.426921894831614 bayes_pls_golite062009
  • DNA binding
    		•  0.278017923256183 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.27489371858599 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.0719543694089202 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.00678211696545472 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle