YRC Public Data Repository - Protein Structure Prediction

Protein:	HPGDS_RAT
Organism:	Rattus norvegicus
Length:	199 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPGDS_RAT.

Description	E-value	Query Range	Subject Range
gi\|67548282, gi\|... - gi\|67548282\|ref\|ZP_00426173.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	167.0	[0..3]	[192..321]
gi\|67104621, gi\|... - gi\|67662036\|ref\|ZP_00459327.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	164.0	[0..3]	[192..20]
gi\|45519430, gi\|... - gi\|73540704\|ref\|YP_295224.1\| glutathione S-transferase [Ralstonia eutropha JMP134], gi\|72118117\|gb\|A...	163.0	[0..4]	[192..1]
gi\|17429039 - gi\|17429039\|emb\|CAD15723.1\| probable glutathione-s-transferase protein [Ralstonia solanacearum GMI10... gi\|17546740 - gi\|17546740\|ref\|NP_520142.1\| putative GST-related protein [Ralstonia solanacearum GMI1000]	163.0	[0..4]	[192..1]
GSTF3_MAIZE - Glutathione S-transferase 3 OS=Zea mays GN=GST3 PE=1 SV=4	163.0	[0..1]	[192..1]
gi\|83748056, gi\|... - gi\|83748056\|ref\|ZP_00945085.1\| Glutathione S-transferase [Ralstonia solanacearum UW551], gi\|83725242... gi\|207742775, gi... - gi\|207742775\|ref\|YP_002259167.1\| glutathione-s-transferase protein [Ralstonia solanacearum IPO1609],...	163.0	[0..4]	[198..1]
gi\|48770838, gi\|... - gi\|94309912\|ref\|YP_583122.1\| glutathione S-transferase-like protein [Ralstonia metallidurans CH34], ...	163.0	[0..8]	[192..5]
gi\|113525886, gi... - gi\|113867110\|ref\|YP_725599.1\| glutathione S-transferase [Ralstonia eutropha H16], gi\|113525886\|emb\|C...	163.0	[0..4]	[192..1]
gi\|116648338, gi... - gi\|116690249\|ref\|YP_835872.1\| glutathione S-transferase domain-containing protein [Burkholderia ceno... gi\|67660951, gi\|... - gi\|67660951\|ref\|ZP_00458284.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	163.0	[0..4]	[192..1]
gi\|116331951, gi... - gi\|116331951\|ref\|YP_801669.1\| glutathione transferase [Leptospira borgpetersenii serovar Hardjo-bovi...	162.0	[0..4]	[189..1]

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Predicted Domain #1

Region A:
Residues: [1-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNYKLLYFN MRGRAEIIRY IFAYLDIKYE DHRIEQADWP KIKPTLPFGK IPVLEVEGLT  60
   61 LHQSLAIARY LTKNTDLAGK TELEQCQVDA VVDTLDDFMS LFPWAEENQD LKERTFNDLL 120
  121 TRQAPHLLKD LDTYLGDKEW FIGNYVTWAD FYWDICSTTL LVLKPDLLGI YPRLVSLRNK 180
  181 VQAIPAISAW ILKRPQTKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.30103
Match:	1pd21
Description:	Class sigma GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutathione transferase activity	4.50796867464992	bayes_pls_golite062009
prostaglandin-D synthase activity	3.77818075962089	bayes_pls_golite062009
glutathione binding	3.70571520983029	bayes_pls_golite062009
antioxidant activity	3.66884588063322	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
selenium binding	2.55069860113032	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
molecular transducer activity	1.03696928411308	bayes_pls_golite062009
signal transducer activity	1.03696928411308	bayes_pls_golite062009
phospholipid-hydroperoxide glutathione peroxidase activity	0.874146425427531	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transcription regulator activity	0.52671047749426	bayes_pls_golite062009
receptor binding	0.430107649265259	bayes_pls_golite062009
maleylacetoacetate isomerase activity	0.426921894831614	bayes_pls_golite062009
DNA binding	0.278017923256183	bayes_pls_golite062009
nucleic acid binding	0.27489371858599	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.0719543694089202	bayes_pls_golite062009
transcription repressor activity	0.00678211696545472	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: