Protein Overview: PGH2_RAT

General Information:
Name(s) found:	PGH2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|743591\|prf\|\|2013181A growth factor-inducible cyclooxygenase [NCBI NR] gi\|548484\|sp\|P35355.1\|PGH2_RAT RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; Alt [NCBI NR] pir\|\|JC2030 prostaglandin-endoperoxide synthase (EC 1.14.99.1) 2 precursor - rat [NCBI NR] gi\|516872\|gb\|AAA20246.1\| mitogen inducible cyclooxygenase [NCBI NR] gi\|414813\|gb\|AAA16477.1\| cyclooxygenase-2 [NCBI NR] gi\|149058429\|gb\|EDM09586.1\| prostaglandin-endoperoxide synthase 2, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|148747270\|ref\|NP_058928.3\| prostaglandin-endoperoxide synthase 2 [Rattus norvegicus] [NCBI NR] Prostaglandin G/H synthase 2 OS=Rattus norvegicus GN=Ptgs2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):13-55545114 Prostaglandin G/H synthase 2 precursor [hmr_yeast5_DM3-1_pombe.fasta] prostaglandin-endoperoxide synthase (EC 1.14.99.1) 2 precursor - ratgi\|548484\|sp\|P35355\|PGH2_RAT Prostaglandin G/H synthase 2 precursor (Cyclooxygenase -2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PG [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Prostaglandin G/H synthase 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] prostaglandin-endoperoxide synthase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Prostaglandin G/H synthase 2 precursor (Cyclooxygenase-2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] prostaglandin-endoperoxide synthase 2, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] growth factor-inducible cyclooxygenase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] mitogen inducible cyclooxygenase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cyclooxygenase-2 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROSTAGLANDIN G/H SYNTHASE 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ptgs2 Prostaglandin G/H synthase 2 [rat-ipi-250309-contam.fasta] Prostaglandin G/H synthase 2 OS=Rattus norvegicus GN=Ptgs2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	604 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [TAS] endoplasmic reticulum membrane [IEA] nucleus [UNKNOWN][ISS] endoplasmic reticulum lumen [UNKNOWN] caveola [IDA] cytoplasm [UNKNOWN][IDA][ISS] membrane [IEA] microsome [IEA] endoplasmic reticulum [TAS] protein complex [IDA]
Biological Process:	response to manganese ion [IEP] response to cytokine stimulus [IMP] response to vitamin D [IEP] response to fructose stimulus [IEP] negative regulation of cell proliferation [IDA] positive regulation of cell proliferation [TAS] positive regulation of vasoconstriction [IMP] decidualization [IMP] memory [IMP] positive regulation of smooth muscle contraction [IMP] positive regulation of smooth muscle cell proliferation [IMP] response to oxidative stress [IEA] inflammatory response [IMP] ovulation [IMP] positive regulation of synaptic plasticity [IMP] response to glucocorticoid stimulus [IEP] negative regulation of calcium ion transport [IMP] regulation of cell cycle [IEP] positive regulation of synaptic transmission, glutamatergic [IMP] negative regulation of synaptic transmission, dopaminergic [IMP] response to organic substance [IEP] bone mineralization [IMP] anagen [UNKNOWN][IEA] response to organic cyclic substance [IEP] fatty acid biosynthetic process [IEA] regulation of blood pressure [UNKNOWN][ISS] embryo implantation [IMP] regulation of cell proliferation [UNKNOWN] response to drug [IEP] prostaglandin biosynthetic process [IMP][TAS] positive regulation of apoptosis [IMP] response to estradiol stimulus [IEP] response to lipopolysaccharide [IMP] oxidation reduction [IEA] response to organic nitrogen [IEP]
Molecular Function:	peroxidase activity [UNKNOWN][IEA] prostaglandin-endoperoxide synthase activity [TAS] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IDA] protein binding [IPI] oxidoreductase activity [IEA] metal ion binding [IEA] lipid binding [IMP] heme binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFRAVLLCA ALALSHAANP CCSNPCQNRG ECMSIGFDQY KCDCTRTGFY GENCTTPEFL  60
   61 TRIKLLLKPT PNTVHYILTH FKGVWNIVNN IPFLRNSIMR YVLTSRSHLI DSPPTYNVHY 120
  121 GYKSWEAFSN LSYYTRALPP VADDCPTPMG VKGNKELPDS KEVLEKVLLR REFIPDPQGT 180
  181 NMMFAFFAQH FTHQFFKTDQ KRGPGFTRGL GHGVDLNHVY GETLDRQHKL RLFQDGKLKY 240
  241 QVIGGEVYPP TVKDTQVDMI YPPHVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD 300
  301 ILKQEHPEWD DERLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNQQFQYQ 360
  361 NRIASEFNTL YHWHPLLPDT FNIEDQEYTF KQFLYNNSIL LEHGLAHFVE SFTRQIAGRV 420
  421 AGGRNVPIAV QAVAKASIDQ SREMKYQSLN EYRKRFSLKP YTSFEELTGE KEMAAELKAL 480
  481 YHDIDAMELY PALLVEKPRP DAIFGETMVE LGAPFSLKGL MGNPICSPQY WKPSTFGGEV 540
  541 GFRIINTASI QSLICNNVKG CPFASFNVQD PQPTKTATIN ASASHSRLDD INPTVLIKRR 600
  601 STEL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: PGH2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: