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Protein Overview: BMP4_RAT

General Information:
Name(s) found: BMP4_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Bone morphogenetic protein 4 OS=Rattus norvegicus GN=Bmp4 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 408 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    membrane-bounded vesicle [IDA]
    cytoplasm [IDA]
    extracellular region [UNKNOWN][IEA]
    proteinaceous extracellular matrix [IEA]
    Biological Process: cranial suture morphogenesis [UNKNOWN]
    post-embryonic development [UNKNOWN][IEA]
    mesoderm development [NAS]
    tongue morphogenesis [IEP]
    branching morphogenesis of a tube [UNKNOWN][ISS]
    hemopoietic progenitor cell differentiation [UNKNOWN][ISS]
    activation of MAPKK activity [UNKNOWN][ISS]
    positive regulation of gene-specific transcription [UNKNOWN]
    kidney development [UNKNOWN][ISS]
    mesonephros development [UNKNOWN][IEA][ISS]
    vasculature development [UNKNOWN]
    mesoderm formation [UNKNOWN]
    protein localization in nucleus [UNKNOWN][ISS]
    mammary gland formation [UNKNOWN][IEA]
    cloacal septation [UNKNOWN][IEA]
    anatomical structure formation involved in morphogenesis [UNKNOWN]
    positive regulation of kidney development [UNKNOWN][ISS]
    brain development [IEP]
    response to organic cyclic substance [IEP]
    lens induction in camera-type eye [UNKNOWN][IEA]
    growth [IEA]
    prostate gland morphogenesis [UNKNOWN][IEA]
    positive regulation of ossification [UNKNOWN][IDA][IMP]
    positive regulation of branching involved in ureteric bud morphogenesis [IMP]
    mesenchymal to epithelial transition involved in metanephros morphogenesis [UNKNOWN][IEA][ISS]
    negative regulation of myoblast differentiation [UNKNOWN][IEA]
    negative regulation of transcription [UNKNOWN][IEA][ISS]
    cellular response to growth factor stimulus [UNKNOWN]
    negative regulation of epithelial cell proliferation [UNKNOWN][IEA]
    positive regulation of cell death [UNKNOWN][IEA]
    cell proliferation [NAS]
    negative regulation of MAP kinase activity [UNKNOWN][ISS]
    telencephalon development [UNKNOWN]
    negative regulation of cell proliferation [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN][IMP]
    negative regulation of cell cycle [UNKNOWN][IEA][ISS]
    regulation of smooth muscle cell differentiation [UNKNOWN]
    positive regulation of neuron differentiation [UNKNOWN]
    negative regulation of cell death [UNKNOWN][ISS]
    epithelium development [UNKNOWN]
    positive regulation of osteoblast differentiation [UNKNOWN][IDA][IMP][ISS]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    pathway-restricted SMAD protein phosphorylation [UNKNOWN][ISS]
    lung morphogenesis [UNKNOWN]
    positive regulation of smooth muscle cell proliferation [UNKNOWN][IEA][ISS]
    heart development [UNKNOWN][IEA]
    regulation of smooth muscle cell proliferation [UNKNOWN]
    smooth muscle cell differentiation [UNKNOWN][IEA]
    angiogenesis [UNKNOWN][IEA]
    neuron fate commitment [UNKNOWN][IEA]
    camera-type eye development [UNKNOWN]
    response to glucocorticoid stimulus [IEP]
    osteoblast differentiation [UNKNOWN]
    positive regulation of SMAD protein nuclear translocation [UNKNOWN][IEA][ISS]
    positive regulation of endothelial cell migration [UNKNOWN][ISS]
    negative regulation of mitosis [UNKNOWN][ISS]
    embryonic cranial skeleton morphogenesis [UNKNOWN][IEA]
    ovarian follicle development [IMP]
    negative regulation of phosphorylation [UNKNOWN][ISS]
    metanephros development [UNKNOWN][ISS]
    ureteric bud development [UNKNOWN][IEA]
    branching involved in ureteric bud morphogenesis [UNKNOWN][ISS]
    positive regulation of protein amino acid phosphorylation [UNKNOWN]
    cell fate commitment [UNKNOWN]
    positive regulation of endothelial cell proliferation [UNKNOWN][ISS]
    cellular response to dexamethasone stimulus [IDA]
    intermediate mesodermal cell differentiation [UNKNOWN][IEA][ISS]
    trachea formation [UNKNOWN]
    branching involved in lung morphogenesis [UNKNOWN][IEP]
    branching involved in prostate gland morphogenesis [UNKNOWN]
    epithelial-mesenchymal cell signaling [UNKNOWN]
    retina development in camera-type eye [IEP]
    branch elongation involved in ureteric bud branching [UNKNOWN][IEA][ISS]
    bud elongation involved in lung branching [UNKNOWN]
    negative regulation of prostatic bud formation [UNKNOWN][IEA]
    regulation of branching involved in prostate gland morphogenesis [UNKNOWN][IEA]
    renal system process [UNKNOWN][IEA]
    negative regulation of striated muscle tissue development [UNKNOWN][IEA]
    negative regulation of oligodendrocyte differentiation [IMP]
    regulation of morphogenesis of a branching structure [UNKNOWN]
    embryonic digit morphogenesis [UNKNOWN][IEA]
    lung alveolus development [UNKNOWN][IEA]
    response to retinoic acid [IEP]
    skeletal system development [UNKNOWN]
    forebrain development [UNKNOWN][IEA]
    BMP signaling pathway [UNKNOWN][IEA][ISS]
    positive regulation of bone mineralization [UNKNOWN][IEA][ISS]
    dorsal/ventral neural tube patterning [UNKNOWN][IEA]
    SMAD protein signal transduction [UNKNOWN][ISS]
    trachea development [UNKNOWN][IEA]
    bronchus development [UNKNOWN][IEA]
    ureteric bud morphogenesis [UNKNOWN]
    mesodermal cell fate determination [UNKNOWN][IEA]
    tissue development [UNKNOWN]
    pituitary gland development [UNKNOWN][IEA]
    negative regulation of gene expression [UNKNOWN]
    erythrocyte differentiation [UNKNOWN][IEA]
    positive regulation of gene expression [UNKNOWN][IEA]
    mesodermal cell differentiation [UNKNOWN]
    induction of an organ [UNKNOWN][IEA]
    regulation of gene expression [UNKNOWN]
    response to estradiol stimulus [IEP]
    positive regulation of pathway-restricted SMAD protein phosphorylation [UNKNOWN][IEA][ISS]
    cartilage development [IEA]
    positive regulation of cartilage development [UNKNOWN]
    telencephalon regionalization [UNKNOWN][IEA]
    bud dilation involved in lung branching [UNKNOWN][IEA]
    odontogenesis of dentine-containing tooth [UNKNOWN][IEA]
    odontogenesis [UNKNOWN][IEP][ISS]
    negative regulation of glomerulus development [UNKNOWN][ISS]
    negative regulation of branching involved in ureteric bud morphogenesis [UNKNOWN][IEA][ISS]
    response to mechanical stimulus [IEP]
    bone development [UNKNOWN]
    epithelial cell proliferation involved in lung morphogenesis [UNKNOWN][IEA]
    blood vessel development [UNKNOWN]
    regulation of cell differentiation [UNKNOWN][IDA]
    specification of organ position [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IDA]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    lung development [UNKNOWN]
    germ cell development [UNKNOWN][IEA]
    negative regulation of gene-specific transcription [UNKNOWN][ISS]
    smooth muscle tissue development [IEA][ISS]
    positive regulation of cell differentiation [UNKNOWN]
    regulation of odontogenesis of dentine-containing tooth [UNKNOWN]
    camera-type eye morphogenesis [UNKNOWN][IEA]
    embryonic morphogenesis [UNKNOWN]
    negative regulation of apoptosis [UNKNOWN][IEA][ISS]
    positive regulation of apoptosis [UNKNOWN][IEA][ISS]
    positive regulation of ERK1 and ERK2 cascade [UNKNOWN]
    negative regulation of chondrocyte differentiation [UNKNOWN][IEA]
    Molecular Function: growth factor activity [IDA]
    protein binding [UNKNOWN][IEA]
    protein homodimerization activity [IDA]
    chemoattractant activity [UNKNOWN][ISS]
    heparin binding [UNKNOWN][IEA]
    transcription activator activity [UNKNOWN]
    cytokine activity [UNKNOWN][IEA]
    transcription repressor activity [UNKNOWN][ISS]
    BMP receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPGNRMLMV VLLCQVLLGG ATDASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT  60
   61 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 120
  121 FHHEEHLENI PGTSESSAFR FFFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 180
  181 IYEVMKPPAE MVPGHLITRL LDTRLVRHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 240
  241 HLHQTRTHQG QHVRISRSLP QGSGNWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300
  301 SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 360
  361 VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle