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Protein Overview: OREX_RAT

General Information:
Name(s) found: OREX_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6981016|ref|NP_037311.1| hypocretin [Rattus norvegicus] [NCBI NR]
  • gi|6225803|sp|O55232.1|OREX_RAT RecName: Full=Orexin; AltName: Full=Hypocretin; Short=Hcrt; Contains: RecName: Full=Orexin-A; AltName: Full=Hypocretin-1; Short=Hcrt1; Contains: RecName: Full=Orexin-B; AltName: Full=Hypocretin-2; Short=Hcrt2; Flags: Precur [NCBI NR]
  • gi|2897120|gb|AAC40039.1| prepro-orexin; PPOX; neuropeptide precursor [Rattus norvegicus] [NCBI NR]
  • gi|2895194|gb|AAC02933.1| preprohypocretin [Rattus norvegicus] [NCBI NR]
  • gi|149054248|gb|EDM06065.1| hypocretin, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • Orexin OS=Rattus norvegicus GN=Hcrt PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-87941957 Orexin precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • hypocretin; Hypocretin (orexin) neuropeptide precursor [HMR_022704-rand.fasta]
  • hypocretin [Rattus norvegicus]gi|6225803|sp|O55232|OREX_RAT Orexin precursor (Hypocretin) (Hcrt) [Contains: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]gi|2897120|gb|AAC40039.1| prepro-orexin; PPOX; neuropeptide precursor [Rattus no [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Orexin precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_013179) hypocretin (orexin) neuropeptide precursor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Orexin precursor (Hypocretin) (Hcrt) [Contains: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • hypocretin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • hypocretin, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • prepro-orexin; PPOX; neuropeptide precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • preprohypocretin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 OREXIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Hcrt Orexin [rat-ipi-250309-contam.fasta]
  • Orexin OS=Rattus norvegicus GN=Hcrt [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 130 amino acids

    Gene Ontology:
    Cellular Component: perinuclear region of cytoplasm [UNKNOWN][IEA]
    cytoplasm [IDA]
    secretory granule [IDA]
    rough endoplasmic reticulum [IEA]
    Biological Process: regulation of neurotransmitter secretion [IDA]
    regulation of excitatory postsynaptic membrane potential [IDA]
    positive regulation of calcium ion transport [IMP]
    feeding behavior [IEA][NAS]
    activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [IMP]
    negative regulation of DNA replication [IDA]
    negative regulation of potassium ion transport [IDA]
    activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IMP]
    behavioral fear response [NAS]
    elevation of cytosolic calcium ion concentration [IDA]
    eating behavior [IDA]
    neuropeptide signaling pathway [IEA]
    negative regulation of transmission of nerve impulse [IDA]
    positive regulation of transmission of nerve impulse [IDA]
    temperature homeostasis [IDA]
    [NOT]release of sequestered calcium ion into cytosol [IMP]
    Molecular Function: neuropeptide hormone activity [IDA][TAS]
    type 2 hypocretin receptor binding [IDA]
    type 1 hypocretin receptor binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLPSTKVPW AAVTLLLLLL LPPALLSLGV DAQPLPDCCR QKTCSCRLYE LLHGAGNHAA  60
   61 GILTLGKRRP GPPGLQGRLQ RLLQANGNHA AGILTMGRRA GAELEPYPCP GRRCPTATAT 120
  121 ALAPRGGSRV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] Pfam 103.21467 No description for PF02072.6 was found. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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