Protein Overview: ROBO1_RAT

General Information:
Name(s) found:	ROBO1_RAT [Swiss-Prot]
Description(s) found: Found 18 descriptions. SHOW ALL	Roundabout homolog 1 OS=Rattus norvegicus GN=Robo1 PE=1 SV=1 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	1651 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [UNKNOWN][IEA] membrane [IEA] integral to membrane [IEA] axolemma [UNKNOWN][IEA] neuronal cell body [IDA] plasma membrane [UNKNOWN] axon [IDA] cell surface [UNKNOWN][IEA]
Biological Process:	Roundabout signaling pathway [UNKNOWN] multicellular organismal development [IEA] negative regulation of cell proliferation [UNKNOWN] chemorepulsion involved in postnatal olfactory bulb interneuron migration [UNKNOWN][IEA] axon guidance [UNKNOWN][IDA] cell migration involved in sprouting angiogenesis [UNKNOWN][IEA] homophilic cell adhesion [UNKNOWN][IEA] mammary duct terminal end bud growth [UNKNOWN] regulation of dendrite morphogenesis [IMP] spinal cord development [IEP] chemotaxis [IEA] central nervous system development [IEP] olfactory bulb interneuron development [IEA] positive regulation of axonogenesis [UNKNOWN][IEA] negative regulation of chemokine-mediated signaling pathway [UNKNOWN] cell differentiation [IEA] negative regulation of negative chemotaxis [UNKNOWN] axon midline choice point recognition [IEP] activation of caspase activity [UNKNOWN][IEA] negative regulation of mammary gland epithelial cell proliferation [UNKNOWN]
Molecular Function:	identical protein binding [UNKNOWN][IEA] protein binding [UNKNOWN][IPI] protein heterodimerization activity [UNKNOWN][IEA] LRR domain binding [UNKNOWN][IEA] axon guidance receptor activity [IDA] receptor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWKHLPLLV MISLLTLSKK HLLLAQLIPD PEDLERGNDN GTPAPTSDND DNSLGYTGSR  60
   61 LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDDPRSHRM 120
  121 LLPSGSLFFL RIVHGRKSRP DEGVYICVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM 180
  181 VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC 240
  241 VGTNMVGERE SKVADVTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTFGWRKDDG 300
  301 ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ 360
  361 VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTVTNVQR 420
  421 SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TLTLSCVATG 480
  481 SPVPTILWRK DGVLVSTQDS RIKQLESGVL QIRYAKLGDT GRYTCTASTP SGEATWSAYI 540
  541 EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSKNTVTLL WQPNLNSGAT PTSYIIEAFS 600
  601 HASGSSWQTV AENVKTETFA IKGLKPNAIY LFLVRAANAY GISDPSQISD PVKTQDVPPT 660
  661 TQGVDHKQVQ RELGNVVLHL HNPTILSSSS VEVHWTVDQQ SQYIQGYKIL YRPSGASHGE 720
  721 SEWLVFEVRT PTKNSVVIPD LRKGVNYEIK ARPFFNEFQG ADSEIKFAKT LEERPSAPPR 780
  781 SVTVSKNDGN GTAILVTWQP PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP 840
  841 FLVPGIRYSV EVAASTGAGP GVKSEPQFIQ LDSHGNPVSP EDQVSLAQQI SDVVKQPAFI 900
  901 AGIGAACWII LMVFSIWLYR HRKKRNGLSS TYAGIRKVPS FTFTPTVTYQ RGGEAVSSGG 960
  961 RPGLLNISEP ATQPWLADTW PNTGNSHNDC SINCCTASNG NSDSNLTTYS RPADCIANYN1020
 1021 NQLDNKQTNL MLPESTVYGD VDLSNKINEM KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ1080
 1081 ANLINNMNNG GGDSSEKHWK PPGQQKQEVA PIQYNIMEQN KLNKDYRAND TILPTIPYNH1140
 1141 SYDQNTGGSY NSSDRGSSTS GSQGHKKGAR TPKAPKQGGM NWADLLPPPP AHPPPHSNSE1200
 1201 EYSMSVDESY DQEMPCPVPP ARMYLQQDEL EEEEAERGPT PPVRGAASSP AAVSYSHQST1260
 1261 ATLTPSPQEE LQPMLQDCPE DLGHMPHPPD RRRQPVSPPP PPRPISPPHT YGYISGPLVS1320
 1321 DMDTDAPEEE EDEADMEVAK MQTRRLLLRG LEQTPASSVG DLESSVTGSM INGWGSASEE1380
 1381 DNISSGRSSV SSSDGSFFTD ADFAQAVAAA AEYAGLKVAR RQMQDAAGRR HFHASQCPRP1440
 1441 TSPVSTDSNM SAAVIQKARP TKKQKHQPGH LRREAYTDDL PPPPVPPPAI KSPSVQSKAQ1500
 1501 LEARPIMGPK LASIEARADR SSDRKGGSYK GREALDGRQV TDLRTSPGDP REAQEQPNEG1560
 1561 KARGTKTAKR DLPPAKTHLI PEDILPYCRP TFPTSNNPRD PSSSSSMSSR GSGSRQREQA1620
 1621 NVGRRNMAEM QVLGGFERGD ENNEELEETE S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ROBO1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: