Protein Overview: NOS1_RAT

General Information:
Name(s) found:	NOS1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|266646\|sp\|P29476.1\|NOS1_RAT RecName: Full=Nitric oxide synthase, brain; AltName: Full=BNOS; AltName: Full=NOS type I; AltName: Full=Neuronal NOS; Short=N-NOS; Short=nNOS; AltName: Full=Constitutive NOS; AltName: Full=NC-NOS [NCBI NR] gi\|227859\|prf\|\|1712320A nitric oxide synthase [NCBI NR] pir\|\|S16233 nitric-oxide synthase (EC 1.14.13.39) - rat [NCBI NR] Nitric oxide synthase, brain OS=Rattus norvegicus GN=Nos1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):12-40782245 Splice isoform N-NOS-1 of P29476 [hmr_yeast5_DM3-1_pombe.fasta] nitric oxidase synthase [Rattus rattus]gi\|112026\|pir\|\|S16233 nitric-oxide synthase (EC 1.14.13.39) - ratgi\|266646\|sp\|P29476\|NOS1_RAT Nitric-oxide synthase, brain (NOS, type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (BNOS)gi\|227859\|pr [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform N-NOS-1 of Nitric-oxide synthase, brain [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Nitric oxide synthase, brain (BNOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] nitric oxide synthase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF NITRIC-OXIDE SYNTHASE, BRAIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Nitric-oxide synthase, brain (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (BNOS) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Nos1 Isoform N-NOS-1 of Nitric oxide synthase, brain [rat-ipi-250309-contam.fasta] Isoform N-NOS-1 of Nitric oxide synthase, brain OS=Rattus norvegicus GN=Nos1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1429 amino acids
Gene Ontology:
Cellular Component:	sarcoplasmic reticulum [UNKNOWN] synapse [UNKNOWN][IDA] mitochondrial outer membrane [IDA] cell projection [IEA] plasma membrane [IDA] nucleus [IDA] dendrite [IDA] nuclear membrane [IDA] perinuclear region of cytoplasm [IDA] cytoplasm [IDA] sarcolemma [UNKNOWN][IDA] mitochondrion [IDA] azurophil granule [IDA] dendritic spine [IEA] cytosol [IDA] photoreceptor inner segment [IDA]
Biological Process:	response to estrogen stimulus [IDA] exogenous drug catabolic process [UNKNOWN] positive regulation of vasodilation [UNKNOWN][IMP] negative regulation of potassium ion transport [UNKNOWN] negative regulation of insulin secretion [IMP] striated muscle contraction [UNKNOWN] negative regulation of heart contraction [IMP] response to ethanol [IEP] negative regulation of hydrolase activity [UNKNOWN] response to heat [UNKNOWN][IEP] response to hypoxia [UNKNOWN][IEP] multicellular organismal response to stress [UNKNOWN] negative regulation of calcium ion transport [UNKNOWN] peptidyl-cysteine S-nitrosylation [UNKNOWN] response to vitamin E [IEP] regulation of heart contraction [IMP] negative regulation of blood pressure [IMP] response to organic cyclic substance [IEP] aging [IEP] arginine catabolic process [IDA] regulation of sodium ion transport [UNKNOWN] oxidation reduction [IEA] nitric oxide biosynthetic process [IDA][IEA] response to organic nitrogen [IEP] regulation of sensory perception of pain [IMP]
Molecular Function:	protein homodimerization activity [IDA] FMN binding [IDA][IEA][TAS] heme binding [IDA][IEA][TAS] calmodulin binding [IDA][IEA] NADP or NADPH binding [IDA][IEA][TAS] protein binding [UNKNOWN][IPI] nitric-oxide synthase activity [IDA][IEA][TAS] oxidoreductase activity [IEA] metal ion binding [IEA] FAD binding [IDA][IEA][TAS] cadmium ion binding [IDA] amino acid binding [TAS] enzyme binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEENTFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA  60
   61 GDIILAVNDR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI 120
  121 RVTQPLGPPT KAVDLSHQPS ASKDQSLAVD RVTGLGNGPQ HAQGHGQGAG SVSQANGVAI 180
  181 DPTMKSTKAN LQDIGEHDEL LKEIEPVLSI LNSGSKATNR GGPAKAEMKD TGIQVDRDLD 240
  241 GKSHKAPPLG GDNDRVFNDL WGKDNVPVIL NNPYSEKEQS PTSGKQSPTK NGSPSRCPRF 300
  301 LKVKNWETDV VLTDTLHLKS TLETGCTEHI CMGSIMLPSQ HTRKPEDVRT KDQLFPLAKE 360
  361 FLDQYYSSIK RFGSKAHMDR LEEVNKEIES TSTYQLKDTE LIYGAKHAWR NASRCVGRIQ 420
  421 WSKLQVFDAR DCTTAHGMFN YICNHVKYAT NKGNLRSAIT IFPQRTDGKH DFRVWNSQLI 480
  481 RYAGYKQPDG STLGDPANVQ FTEICIQQGW KAPRGRFDVL PLLLQANGND PELFQIPPEL 540
  541 VLEVPIRHPK FDWFKDLGLK WYGLPAVSNM LLEIGGLEFS ACPFSGWYMG TEIGVRDYCD 600
  601 NSRYNILEEV AKKMDLDMRK TSSLWKDQAL VEINIAVLYS FQSDKVTIVD HHSATESFIK 660
  661 HMENEYRCRG GCPADWVWIV PPMSGSITPV FHQEMLNYRL TPSFEYQPDP WNTHVWKGTN 720
  721 GTPTKRRAIG FKKLAEAVKF SAKLMGQAMA KRVKATILYA TETGKSQAYA KTLCEIFKHA 780
  781 FDAKAMSMEE YDIVHLEHEA LVLVVTSTFG NGDPPENGEK FGCALMEMRH PNSVQEERKS 840
  841 YKVRFNSVSS YSDSRKSSGD GPDLRDNFES TGPLANVRFS VFGLGSRAYP HFCAFGHAVD 900
  901 TLLEELGGER ILKMREGDEL CGQEEAFRTW AKKVFKAACD VFCVGDDVNI EKPNNSLISN 960
  961 DRSWKRNKFR LTYVAEAPDL TQGLSNVHKK RVSAARLLSR QNLQSPKFSR STIFVRLHTN1020
 1021 GNQELQYQPG DHLGVFPGNH EDLVNALIER LEDAPPANHV VKVEMLEERN TALGVISNWK1080
 1081 DESRLPPCTI FQAFKYYLDI TTPPTPLQLQ QFASLATNEK EKQRLLVLSK GLQEYEEWKW1140
 1141 GKNPTMVEVL EEFPSIQMPA TLLLTQLSLL QPRYYSISSS PDMYPDEVHL TVAIVSYHTR1200
 1201 DGEGPVHHGV CSSWLNRIQA DDVVPCFVRG APSFHLPRNP QVPCILVGPG TGIAPFRSFW1260
 1261 QQRQFDIQHK GMNPCPMVLV FGCRQSKIDH IYREETLQAK NKGVFRELYT AYSREPDRPK1320
 1321 KYVQDVLQEQ LAESVYRALK EQGGHIYVCG DVTMAADVLK AIQRIMTQQG KLSEEDAGVF1380
 1381 ISRLRDDNRY HEDIFGVTLR TYEVTNRLRS ESIAFIEESK KDADEVFSS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: NOS1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: