Protein Overview: RAF1_RAT

General Information:
Name(s) found:	RAF1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981458\|ref\|NP_036771.1\| v-raf-leukemia viral oncogene 1 [Rattus norvegicus] [NCBI NR] pir\|\|TVRTRF protein kinase raf-1 (EC 2.7.1.-) - rat [NCBI NR] gi\|38303885\|gb\|AAH62071.1\| V-raf-leukemia viral oncogene 1 [Rattus norvegicus] [NCBI NR] gi\|206545\|gb\|AAA42001.1\| raf protein [NCBI NR] gi\|149049695\|gb\|EDM02149.1\| v-raf-1 murine leukemia viral oncogene homolog 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|149049694\|gb\|EDM02148.1\| v-raf-1 murine leukemia viral oncogene homolog 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|125653\|sp\|P11345.1\|RAF1_RAT RecName: Full=RAF proto-oncogene serine/threonine-protein kinase; AltName: Full=C-RAF; Short=cRaf; AltName: Full=Raf-1 [NCBI NR] RAF proto-oncogene serine/threonine-protein kinase OS=Rattus norvegicus GN=Raf1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-157009616 RAF proto-oncogene serine/threonine-protein kinase [hmr_yeast5_DM3-1_pombe.fasta] murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); v-raf-1 murine leukemia viral oncogene homolog 1 [HMR_022704-rand.fasta] murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) [Rattus norvegicus]gi\|38303885\|gb\|AAH62071.1\| Murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) [Rattus norvegicus]gi\|66763\|pir\|\|TVRTRF protein kinase raf-1 (EC 2.7.1.-) - ratgi\| [nrdb_11152004_Chlamydomonas] Tax_Id=10116 RAF proto-oncogene serine/threonine-protein kinase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012639) v-raf-1 murine leukemia viral oncogene homolog 1; Murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] V-raf-leukemia viral oncogene 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] RAF proto-oncogene serine/threonine-protein kinase (C-RAF) (cRaf) (Raf-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] v-raf-leukemia viral oncogene 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] v-raf-1 murine leukemia viral oncogene homolog 1, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] raf protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF) (cRaf) [nr-271106-contam.fasta] V-raf-1 murine leukemia viral oncogene homolog 1 [Rattus norvegicus] [nr-271106-contam.fasta] murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Raf1 RAF proto-oncogene serine/threonine-protein kinase [rat-ipi-250309-contam.fasta] RAF proto-oncogene serine/threonine-protein kinase OS=Rattus norvegicus GN=Raf1 [011711_HMR.fasta] Isoform of P11345, Protein kinase C OS=Rattus norvegicus GN=Raf1 PE=1 SV=2 [RAT.fasta.20160308]
Organism:	Rattus norvegicus
Length:	648 amino acids
Gene Ontology:
Cellular Component:	insoluble fraction [IDA] cytosol [UNKNOWN][TAS] plasma membrane [UNKNOWN]
Biological Process:	MAPKKK cascade [IDA][IMP] heart development [IEP] nerve growth factor receptor signaling pathway [UNKNOWN] response to hypoxia [IDA] cytoskeleton organization [UNKNOWN] signal transduction [IEA] small GTPase mediated signal transduction [UNKNOWN] negative regulation of cell proliferation [UNKNOWN] apoptosis [UNKNOWN] intracellular protein kinase cascade [TAS] Ras protein signal transduction [UNKNOWN] protein amino acid phosphorylation [IDA][IEA][IMP][TAS]
Molecular Function:	nucleotide binding [IEA] ATP binding [IDA][IEA] protein binding [UNKNOWN][IPI] metal ion binding [IEA] protein heterodimerization activity [IPI] receptor signaling protein activity [IEA] MAP kinase kinase kinase activity [IDA][IMP][TAS] protein serine/threonine kinase activity [IEA] transferase activity [IEA] kinase activity [UNKNOWN] mitogen-activated protein kinase kinase binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHIQGAWKT ISNGFGLKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV  60
   61 FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLQEHKGKKA RLDWNTDAAS 120
  121 LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180
  181 PTMCVDWSNI RQLLLFPNST ASDSGVPAPP SFTMRRMRES VSRMPASSQH RYSTPHAFTF 240
  241 NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300
  301 SPTGWSQPKT PVPAQRERAP GSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360
  361 GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420
  421 TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480
  481 TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540
  541 LMTGELPYSH INNRDQIIFM VGRGYASPDL SRLYKNCPKA MKRLVADCVK KVKEERPLFP 600
  601 QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: RAF1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: