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Protein Overview: RAF1_RAT

General Information:
Name(s) found: RAF1_RAT [Swiss-Prot]
Description(s) found:
Found 25 descriptions.
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  • RAF proto-oncogene serine/threonine-protein kinase OS=Rattus norvegicus GN=Raf1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 648 amino acids

    Gene Ontology:
    Cellular Component: insoluble fraction [IDA]
    cytosol [UNKNOWN][TAS]
    plasma membrane [UNKNOWN]
    Biological Process: MAPKKK cascade [IDA][IMP]
    heart development [IEP]
    nerve growth factor receptor signaling pathway [UNKNOWN]
    response to hypoxia [IDA]
    cytoskeleton organization [UNKNOWN]
    signal transduction [IEA]
    small GTPase mediated signal transduction [UNKNOWN]
    negative regulation of cell proliferation [UNKNOWN]
    apoptosis [UNKNOWN]
    intracellular protein kinase cascade [TAS]
    Ras protein signal transduction [UNKNOWN]
    protein amino acid phosphorylation [IDA][IEA][IMP][TAS]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA][IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    protein heterodimerization activity [IPI]
    receptor signaling protein activity [IEA]
    MAP kinase kinase kinase activity [IDA][IMP][TAS]
    protein serine/threonine kinase activity [IEA]
    transferase activity [IEA]
    kinase activity [UNKNOWN]
    mitogen-activated protein kinase kinase binding [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHIQGAWKT ISNGFGLKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV  60
   61 FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLQEHKGKKA RLDWNTDAAS 120
  121 LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 180
  181 PTMCVDWSNI RQLLLFPNST ASDSGVPAPP SFTMRRMRES VSRMPASSQH RYSTPHAFTF 240
  241 NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 300
  301 SPTGWSQPKT PVPAQRERAP GSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 360
  361 GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 420
  421 TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 480
  481 TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 540
  541 LMTGELPYSH INNRDQIIFM VGRGYASPDL SRLYKNCPKA MKRLVADCVK KVKEERPLFP 600
  601 QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle