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Protein Overview: MCR_RAT

General Information:
Name(s) found: MCR_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Mineralocorticoid receptor OS=Rattus norvegicus GN=Nr3c2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 981 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IEA]
    nucleus [IDA]
    cytoplasm [IDA]
    membrane [IEA]
    endoplasmic reticulum [IEA]
    Biological Process: mineralocorticoid receptor signaling pathway [IMP]
    regulation of transcription, DNA-dependent [IEA]
    cellular sodium ion homeostasis [UNKNOWN]
    excretion [UNKNOWN]
    regulation of cell proliferation [IDA]
    Molecular Function: zinc ion binding [IEA]
    protein homodimerization activity [IDA]
    double-stranded DNA binding [IDA]
    hormone binding [IDA]
    sequence-specific DNA binding [IDA]
    steroid binding [UNKNOWN][IDA][IMP]
    receptor activity [IEA]
    transcription factor activity [IMP]
    mineralocorticoid receptor activity [IDA]
    protein binding [UNKNOWN]
    metal ion binding [IEA]
    protein heterodimerization activity [IDA]
    steroid hormone receptor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METKGYHSLP EGLDMERRWS QVSQTLERSS LGPAERTTEN NYMEIVNVSC VSGAIPNNST  60
   61 QGSSKEKHEL LPYIQQDNSR SGILPSDIKT ELESKELSAT VAESMGLYMD SVRDAEYTYD 120
  121 QQNQQGSLSP TKIYQNMEQL VKFYKENGHR SSTLSAMSRP LRSFMPDSAA SMNGGALRAI 180
  181 VKSPIICHEK SSSVSSPLNM ASSVCSPVGI NSMSSSTTSF GSFPVHSPIT QGTSLTCSPS 240
  241 VENRGSRSHS PTHASNVGSP LSSPLSSMKS PISSPPSHCS VKSPVSSPNN VPLRSSVSSP 300
  301 ANLNNSRCSV SSPSNNTNNR STLSSPTAST VGSIGSPISN AFSYATSGAS AGAGAIQDVV 360
  361 PSPDTHEKGA HDVPFPKTEE VEKAISNGVT GPLNIVQYIK SEPDGAFSSS CLGGNSKISP 420
  421 SSPFSVPIKQ ESSKHSCSGA SFKGNPTVNP FPFMDGSYFS FMDDKDYYSL SGILGPPVPG 480
  481 FDGSCEDSAF PVGIKQEPDD GSYYPEASIP SSAIVGVNSG GQSFHYRIGA QGTISLSRSP 540
  541 RDQSFQHLSS FPPVNTLVES WKPHGDLSSR RSDGYPVLEY IPENVSSSTL RSVSTGSSRP 600
  601 SKICLVCGDE ASGCHYGVVT CGSCKVFFKR AVEGQHNYLC AGRNDCIIDK IRRKNCPACR 660
  661 LQKCLQAGMN LGARKSKKLG KLKGLHEEQP QQPPPPPPQS PEEGTTYIAP TKEPSVNSAL 720
  721 VPQLTSITHA LTPSPAMILE NIEPETVYAG YDNSKPDTAE SLLSTLNRLA AKQMIQVVKW 780
  781 AKVLPGFKNL PLEDQITLIQ YSWMCLSSFA LSWRSYKHTN SQLLYFAPDL VFNEEKMHQS 840
  841 AMYELCQGMR QISLQFVRLQ LTFEEYSIMK VLLLLSTVPK DGLKSQAAFE EMRTNYIKEL 900
  901 RKMVTKCPNS SGQSWQRFYQ LTKLLDSMHD LVSDLLEFCF YTFRESQALK VEFPAMLVEI 960
  961 ITDQLPKVES GNAKPLYFHR K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle