Protein Overview: I23O1_RAT

General Information:
Name(s) found:	I23O1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|81868291\|sp\|Q9ERD9.1\|I23O_RAT RecName: Full=Indoleamine 2,3-dioxygenase; Short=IDO; AltName: Full=Indoleamine-pyrrole 2,3-dioxygenase [NCBI NR] gi\|13027384\|ref\|NP_076463.1\| indoleamine 2,3-dioxygenase 1 [Rattus norvegicus] [NCBI NR] gi\|11119235\|gb\|AAG30573.1\|AF312699_1 indoleamine 2,3-dioxygenase [Rattus norvegicus] [NCBI NR] Indoleamine 2,3-dioxygenase OS=Rattus norvegicus GN=Indo PE=2 SV=1 [Swiss-Prot] Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus GN=Ido1 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):16_random-926081 Indoleamine 2,3-dioxygenase [hmr_yeast5_DM3-1_pombe.fasta] indoleamine 2,3-dioxygenase [HMR_022704-rand.fasta] indoleamine 2,3-dioxygenase [Rattus norvegicus]gi\|11119235\|gb\|AAG30573.1\| indoleamine 2,3-dioxygenase [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Indoleamine 2,3-dioxygenase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_023973) indoleamine 2,3-dioxygenase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Indoleamine 2,3-dioxygenase (IDO) (Indoleamine-pyrrole 2,3-dioxygenase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] indoleamine-pyrrole 2,3 dioxygenase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] indoleamine 2,3-dioxygenase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INDOLEAMINE 2,3-DIOXYGENASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] indoleamine 2,3-dioxygenase 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ido1 Indoleamine 2,3-dioxygenase [rat-ipi-250309-contam.fasta] Indoleamine 2,3-dioxygenase 1 OS=Rattus norvegicus GN=Ido1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	407 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA] cytoplasm [UNKNOWN][IEA] cytosol [UNKNOWN][IDA]
Biological Process:	negative regulation of interleukin-10 production [UNKNOWN][IEA] kynurenic acid biosynthetic process [UNKNOWN][IEA] negative regulation of activated T cell proliferation [UNKNOWN][IEA] behavior [UNKNOWN][IEA] positive regulation of T-helper 2 type immune response [UNKNOWN][IEA] cytokine production involved in inflammatory response [UNKNOWN][IEA] positive regulation of T cell tolerance induction [UNKNOWN][IEA] inflammatory response [UNKNOWN][IEA] positive regulation of interleukin-12 production [UNKNOWN][IEA] positive regulation of chronic inflammatory response [UNKNOWN][IEA] negative regulation of T cell apoptosis [UNKNOWN][IEA] tryptophan catabolic process to kynurenine [UNKNOWN][IDA] negative regulation of T cell proliferation [UNKNOWN] positive regulation of apoptosis [UNKNOWN][IEA] multicellular organismal response to stress [UNKNOWN][IEA] response to lipopolysaccharide [UNKNOWN][IEA] oxidation reduction [IEA]
Molecular Function:	oxygen binding [IDA] tryptophan 2,3-dioxygenase activity [UNKNOWN][IEA] oxidoreductase activity [IEA] metal ion binding [IEA] amino acid binding [IDA] heme binding [IEA] indoleamine 2,3-dioxygenase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHSQISPAE GSRRILEEYH IDEDVGFALP HPLEELPDTY RPWILVARNL PKLIENGKLR  60
   61 EEVEKLPTLR TEELRGHRLQ RLAHLALGYI TMAYVWNRGD DDIRKVLPRN LAVPYCELSE 120
  121 KLGLPPILSY ADCVLANWKK KDPNGPMTYE NMDILFSFPG GDCDKGFFLV SLMVEIAASP 180
  181 AIKAIPTVSS AVEHQDPKAL EKALCSIAAS LEKAKEIFKR MRDFVDPDTF FHVLRIYLSG 240
  241 WKGNPKLPEG LLYEGVWDTP KKFSGGSAGQ SSIFQSLDVL LGIKHDVGEG SAAEFLQEMR 300
  301 EYMPPAHRNF LSSLESAPPV REFVILRRNE DLKEAYNECV NGLVSLRMFH LSIVDTYIVK 360
  361 PSKQKPMGGH KSEEPSNTEN RGTGGTDVMN FLRSVKDTTK KALLSWP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: I23O1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: