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Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine. Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: indoleamine 2,3-dioxygenase activity
Acc: GO:0033754
Aspect: Molecular Function
Desc: Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms:
  • IDO
  • D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity
  • tryptophan pyrrolase activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0033754 - indoleamine 2,3-dioxygenase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle