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Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: tryptophan 2,3-dioxygenase activity
Acc: GO:0004833
Aspect: Molecular Function
Desc: Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
Synonyms:
  • tryptophan oxygenase activity
  • L-tryptophan pyrrolase activity
  • tryptamine 2,3-dioxygenase activity
  • tryptamin 2,3-dioxygenase activity
  • GO:0004426
  • tryptophan peroxidase activity
  • indolamine 2,3-dioxygenase activity
  • indoleamine-pyrrole 2,3-dioxygenase activity
  • L-tryptophan 2,3-dioxygenase activity
  • tryptophan pyrrolase activity
  • L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  • TDO
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 13 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004833 - tryptophan 2,3-dioxygenase activity (interactive image map)
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