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Protein Overview: STXB1_RAT

General Information:
Name(s) found: STXB1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|7767101|pdb|1DN1|A Chain A, Crystal Structure Of The Neuronal-Sec1SYNTAXIN 1A COMPLEX [NCBI NR]
  • gi|738774|prf||2001428A syntaxin-binding synaptic protein [NCBI NR]
  • gi|6981602|ref|NP_037170.1| syntaxin binding protein 1 [Rattus norvegicus] [NCBI NR]
  • gi|57033186|gb|AAH88850.1| Syntaxin binding protein 1 [Rattus norvegicus] [NCBI NR]
  • gi|48429133|sp|P61765.1|STXB1_RAT RecName: Full=Syntaxin-binding protein 1; AltName: Full=Unc-18 homolog; AltName: Full=Unc-18-1; AltName: Full=Unc-18A; AltName: Full=N-Sec1; AltName: Full=rbSec1; AltName: Full=p67 [NCBI NR]
  • gi|459949|gb|AAA19246.1| n-sec1 [NCBI NR]
  • gi|458342|gb|AAA17987.1| Sec1 homolog [NCBI NR]
  • gi|435433|gb|AAB41113.1| Munc18-1 [Rattus norvegicus] [NCBI NR]
  • gi|149038987|gb|EDL93207.1| syntaxin binding protein 1, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • pir||A53455 syntaxin-binding protein n-Sec1 - rat [NCBI NR]
  • Syntaxin-binding protein 1 OS=Rattus norvegicus GN=Stxbp1 PE=1 SV=1 [Swiss-Prot]
  • (P61765) Syntaxin binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N-Sec1) (rbSec1) (p67) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):3-11708502 Splice isoform 1 of Q64320 [hmr_yeast5_DM3-1_pombe.fasta]
  • syntaxin binding protein 1 [HMR_022704-rand.fasta]
  • STXBP1 protein [Homo sapiens]gi|6981602|ref|NP_037170.1| syntaxin binding protein 1 [Rattus norvegicus]gi|51476961|emb|CAA73255.1| STXBP1 protein [Homo sapiens]gi|17225453|gb|AAL37409.1| syntaxin binding protein 1 [Mus musculus]gi|48429149|sp|P61763|S [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform 1 of Syntaxin-binding protein 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_013038) syntaxin binding protein 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 Splice Isoform 1 of Syntaxin binding protein 1 [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • Syntaxin-binding protein 1 (Unc-18 homolog) (Unc-18-1) (Unc-18A) (N-Sec1) (rbSec1) (p67) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • syntaxin binding protein 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • syntaxin binding protein 1, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Syntaxin binding protein 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Munc18-1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • syntaxin-binding synaptic protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • n-sec1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Sec1 homolog [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Chain A, Crystal Structure Of The Neuronal-Sec1SYNTAXIN 1A COMPLEX [nr-271106-contam.fasta]
  • Syntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N-Sec1) (rbSec1) (p67) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Stxbp1 Isoform 1 of Syntaxin-binding protein 1 [rat-ipi-250309-contam.fasta]
  • Isoform 1 of Syntaxin-binding protein 1 OS=Rattus norvegicus GN=Stxbp1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 594 amino acids

    Gene Ontology:
    Cellular Component: platelet alpha granule [UNKNOWN]
    cytoplasm [IDA]
    mitochondrion [UNKNOWN]
    cytosol [TAS]
    protein complex [IDA]
    plasma membrane [UNKNOWN][IDA]
    Biological Process: neuromuscular synaptic transmission [UNKNOWN]
    protein transport [IEA]
    exocytosis [UNKNOWN]
    neurotransmitter secretion [UNKNOWN]
    axon target recognition [UNKNOWN]
    negative regulation of neuron apoptosis [UNKNOWN]
    platelet degranulation [UNKNOWN]
    negative regulation of synaptic transmission, GABAergic [UNKNOWN]
    cellular membrane fusion [IPI]
    regulation of synaptic vesicle priming [IMP]
    vesicle-mediated transport [IEA]
    vesicle docking during exocytosis [UNKNOWN][IEA]
    synaptic vesicle maturation [UNKNOWN]
    long term synaptic depression [UNKNOWN]
    protein stabilization [IDA]
    platelet aggregation [UNKNOWN]
    Molecular Function: protein domain specific binding [IDA]
    identical protein binding [IPI]
    protein binding [UNKNOWN][IDA][IPI]
    syntaxin binding [IDA]
    syntaxin-1 binding [UNKNOWN][IDA]
    protein N-terminus binding [IDA][IPI]
    SNARE binding [IDA]
    syntaxin-2 binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED  60
   61 INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK 120
  121 SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC 180
  181 ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS 240
  241 SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS 300
  301 QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG 360
  361 TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE 420
  421 ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP 480
  481 IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF 540
  541 ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..594] PSI-BLAST 1000.0 Neuronal Sec1, NSec1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNARE binding
    		•  4.56428593085019 bayes_pls_golite062009
  • syntaxin binding
    		•  3.46044132736061 bayes_pls_golite062009
  • binding
    		•  2.7837022903231 bayes_pls_golite062009
  • protein binding
    		•  1.7224010512877 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.269372794919901 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle