Protein Overview: THRB_RAT

General Information:
Name(s) found:	THRB_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|56970\|emb\|CAA37017.1\| prothrombin precursor [Rattus norvegicus] [NCBI NR] gi\|135809\|sp\|P18292.1\|THRB_RAT RecName: Full=Prothrombin; AltName: Full=Coagulation factor II; Contains: RecName: Full=Activation peptide fragment 1; Contains: RecName: Full=Activation peptide fragment 2; Contains: RecName: Full=Thrombin light chain; Cont [NCBI NR] gi\|12621076\|ref\|NP_075213.1\| coagulation factor II [Rattus norvegicus] [NCBI NR] pir\|\|S10511 thrombin (EC 3.4.21.5) precursor - rat [NCBI NR] Prothrombin OS=Rattus norvegicus GN=F2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):3-69647986 Prothrombin precursor [hmr_yeast5_DM3-1_pombe.fasta] coagulation factor 2; coagulation factor II [HMR_022704-rand.fasta] coagulation factor 2 [Rattus norvegicus]gi\|56970\|emb\|CAA37017.1\| prothrombin precursor [Rattus norvegicus]gi\|112382\|pir\|\|S10511 thrombin (EC 3.4.21.5) precursor - ratgi\|135809\|sp\|P18292\|THRB_RAT Prothrombin precursor [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Prothrombin precursor (Fragment) [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Prothrombin precursor [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_022924) coagulation factor 2; coagulation factor II [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Prothrombin precursor (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] prothrombin precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROTHROMBIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] coagulation factor 2 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=F2 Prothrombin (Fragment) [rat-ipi-250309-contam.fasta] Prothrombin OS=Rattus norvegicus GN=F2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	617 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IDA] extracellular region [UNKNOWN][IDA] plasma membrane [UNKNOWN]
Biological Process:	regulation of cell shape [UNKNOWN] positive regulation of phosphoinositide 3-kinase cascade [UNKNOWN] positive regulation of blood coagulation [UNKNOWN][IEA] positive regulation of cell proliferation [UNKNOWN] response to wounding [UNKNOWN] cytosolic calcium ion homeostasis [UNKNOWN][IEA] negative regulation of astrocyte differentiation [UNKNOWN] cell surface receptor linked signaling pathway [UNKNOWN][IEA] negative regulation of proteolysis [UNKNOWN] blood coagulation [IDA][TAS] positive regulation of release of sequestered calcium ion into cytosol [UNKNOWN][IEA] fibrinolysis [UNKNOWN][IEA] acute-phase response [IEA] response to stress [IEP] positive regulation of cell growth [UNKNOWN] wound healing [TAS] positive regulation of collagen biosynthetic process [UNKNOWN][IEA] positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA] proteolysis [TAS] release of sequestered calcium ion into cytosol [UNKNOWN] platelet activation [UNKNOWN][IEA]
Molecular Function:	thrombospondin receptor activity [UNKNOWN][IEA] protein binding [UNKNOWN] calcium ion binding [IEA] serine-type endopeptidase activity [UNKNOWN][IDA] peptidase activity [UNKNOWN][IEA] receptor binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHVRGLGLP GCLALAALAS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE  60
   61 CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGLNYHGN 120
  121 VSVTHTGIEC QLWRSRYPHR PDINSTTHPG ADLKENFCRN PDSSTSGPWC YTTDPTVRRE 180
  181 ECSIPVCGQE GRTTVKMTPR SRGSKENLSP PLGECLLERG RLYQGNLAVT TLGSPCLAWD 240
  241 SLPTKTLSKY QNFDPEVKLV QNFCRNPDRD EEGAWCFVAQ QPGFEYCSLN YCDEAVGEEN 300
  301 HDGDESIAGR TTDAEFHTFF DERTFGLGEA DCGLRPLFEK KSLTDKTEKE LLDSYIDGRI 360
  361 VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV 420
  421 RIGKHSRTRY ERNVEKISML EKIYIHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP 480
  481 DKQTVTSLLQ AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI 540
  541 TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT 600
  601 HVFRLKRWMQ KVIDQHR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: THRB_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: