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Protein Overview: DRD3_RAT

General Information:
Name(s) found: DRD3_RAT [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • D(3) dopamine receptor OS=Rattus norvegicus GN=Drd3 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 446 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IEA]
    integral to plasma membrane [UNKNOWN][IEA]
    endocytic vesicle [IDA]
    apical part of cell [IDA]
    membrane [IDA]
    cell projection [IDA]
    plasma membrane [UNKNOWN][IDA]
    Biological Process: negative regulation of adenylate cyclase activity [UNKNOWN][IDA]
    activation of adenylate cyclase activity by dopamine receptor signaling pathway [UNKNOWN][IEA]
    regulation of multicellular organism growth [UNKNOWN][IEA]
    acid secretion [IDA]
    regulation of locomotion [IMP]
    positive regulation of dopamine receptor signaling pathway [UNKNOWN][IEA]
    inhibition of adenylate cyclase activity by dopamine receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of cell proliferation [IDA]
    dopamine receptor signaling pathway [IMP][TAS]
    visual learning [UNKNOWN][IEA]
    positive regulation of mitosis [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    negative regulation of oligodendrocyte differentiation [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of blood volume by renin-angiotensin [UNKNOWN][IEA]
    response to ethanol [UNKNOWN][IEA]
    circadian regulation of gene expression [UNKNOWN][IEA]
    synaptic transmission, dopaminergic [IMP]
    locomotory behavior [UNKNOWN][IEA]
    behavioral response to cocaine [UNKNOWN][IEA]
    regulation of dopamine secretion [UNKNOWN][IEA]
    prepulse inhibition [UNKNOWN][IEA]
    G-protein coupled receptor protein signaling pathway [UNKNOWN][IMP]
    signal transduction [IEA]
    negative regulation of protein secretion [UNKNOWN][IEA]
    response to cocaine [UNKNOWN]
    negative regulation of blood pressure [UNKNOWN][IEA]
    G-protein coupled receptor internalization [UNKNOWN][IDA]
    response to morphine [UNKNOWN][IEA]
    cellular calcium ion homeostasis [UNKNOWN][IEA]
    musculoskeletal movement, spinal reflex action [UNKNOWN][IEA]
    negative regulation of sodium:hydrogen antiporter activity [IMP]
    response to amphetamine [UNKNOWN][IEA]
    arachidonic acid secretion [UNKNOWN][IEA]
    regulation of cAMP metabolic process [UNKNOWN][IDA]
    response to drug [IDA][TAS]
    regulation of circadian sleep/wake cycle, sleep [IMP]
    response to histamine [UNKNOWN][IEA]
    negative regulation of dopamine receptor signaling pathway [UNKNOWN][IEA]
    regulation of lipid metabolic process [UNKNOWN][IEA]
    negative regulation of protein kinase B signaling cascade [UNKNOWN][IEA]
    Molecular Function: G-protein coupled receptor activity [IEA]
    dopamine receptor activity [IMP][TAS]
    protein domain specific binding [IPI]
    protein binding [UNKNOWN][IPI]
    drug binding [UNKNOWN][IDA]
    dopamine binding [IMP]
    dopamine receptor activity, coupled via Gi/Go [IDA]
    dopamine D3 receptor activity [UNKNOWN][IEA]
    receptor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPLSQISTH LNSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV CAAVLRERAL  60
   61 QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 120
  121 LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPSI 180
  181 CSISNPDFVI YSSVVSFYVP FGVTVLVYAR IYIVLRQRQR KRILTRQNSQ CISIRPGFPQ 240
  241 QSSCLRLHPI RQFSIRARFL SDATGQMEHI EDKQYPQKCQ DPLLSHLQPP SPGQTHGGLK 300
  301 RYYSICQDTA LRHPSLEGGA GMSPVERTRN SLSPTMAPKL SLEVRKLSNG RLSTSLRLGP 360
  361 LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH CQACHVSPEL YRATTWLGYV 420
  421 NSALNPVIYT TFNVEFRKAF LKILSC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle