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Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Any process that modulates the frequency, rate or extent of cyclase activity. Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction. Any process that modulates the frequency, rate or extent of adenylate cyclase activity. Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity. The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. Any process that stops or reduces the activity of an enzyme. Any process that stops or reduces the activity of a cyclase. Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of adenylate cyclase activity
Acc: GO:0007194
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity.
Synonyms:
  • inhibition of adenylate cyclase activity
  • negative regulation of adenylyl cyclase activity
  • down regulation of adenylate cyclase activity
  • downregulation of adenylate cyclase activity
  • down-regulation of adenylate cyclase activity
  • adenylate cyclase inhibitor
Proteins in PDR annotated with:
   This term: 33 [Search]
   Term or descendants: 94 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007194 - negative regulation of adenylate cyclase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle