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Protein Overview: E2AK2_MOUSE

General Information:
Name(s) found: E2AK2_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|6755160|ref|NP_035293.1| eukaryotic translation initiation factor 2-alpha kinase 2 [Mus musculus] [NCBI NR]
  • gi|536918|gb|AAC24729.1| interferon-inducible RNA-dependent protein kinase [Mus musculus] [NCBI NR]
  • gi|26324546|dbj|BAC26027.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|2507204|sp|Q03963.2|E2AK2_MOUSE RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; AltName: Full=Interferon-inducible RNA-dependent protein kinase; AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Sh [NCBI NR]
  • pir||A59309 interferon-inducible RNA-dependent, translation initiation factor alpha kinase 2 (EC 2.7.1.-) [similarity] - mouse [NCBI NR]
  • (Q03963) Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.1.-) (Interferon-inducible RNA-dependent protein kinase) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK) [Swiss-Prot]
  • Interferon-induced, double-stranded RNA-activated protein kinase OS=Mus musculus GN=Eif2ak2 PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):17-77470649 Interferon-induced, double-stranded RNA-activated protein kinase [hmr_yeast5_DM3-1_pombe.fasta]
  • protein kinase, interferon-inducible double stranded RNA dependent; protein kinase, interferon inducible double stranded RNA dependent; T-cell viral integration site; eukaryotic translation initiation factor 2 alpha kinase 2; eIF-2 alpha; dsRNA-activated [HMR_022704-rand.fasta]
  • Interferon-induced, double-stranded RNA-activated protein kinase [ipi.MOUSE.v3.06.fasta]
  • protein kinase, interferon-inducible double stranded RNA dependent [Mus musculus]gi|11376737|pir||A59309 interferon-inducible RNA-dependent, translation initiation factor alpha kinase 2 (EC 2.7.1.-) [similarity] - mousegi|536918|gb|AAC24729.1| interfero [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Interferon-induced, double-stranded RNA-activated protein kinase [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_011163) eukaryotic translation initiation factor 2 alpha kinase 2; eIF-2 alpha; IFN- type I-induced and dsRNA-activated kinase; IFN-induced and double-stranded RNA-activated kinase; INF type I-induced and dsRNA-activated kinase; INF-induced and double [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • protein kinase, interferon-inducible double stranded RNA dependent [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Interferon-induced, double-stranded RNA-activated protein kinase (Interferon-inducible RNA-dependent protein kinase) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • eukaryotic translation initiation factor 2-alpha kinase 2 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • interferon-inducible RNA-dependent protein kinase [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase [mouse-ipi-250309-contam.fasta]
  • Interferon-induced, double-stranded RNA-activated protein kinase (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK) [nr-271106-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase ENSMUSG00000024079 IPI00138256 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • interferon-induced, double-stranded RNA-activated protein kinase [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00138256.1|SWISS-PROT:Q03963|TREMBL:Q78E06;Q91YN2|ENSEMBL:ENSMUSP00000024884|REFSEQ:NP_035293 Tax_Id=10090 Gene_Symbol=Eif2ak2 Interferon-induced, double-stranded RNA-activated protein kinase [ipi.MOUSE.fasta.20090209]
  • Interferon-induced, double-stranded RNA-activated protein kinase OS=Mus musculus GN=Eif2ak2 [011711_HMR.fasta]
  • sp|Q03963|E2AK2_MOUSE Interferon-induced, double-stranded RNA-activated protein kinase OS=Mus musculus GN=Eif2ak2 PE=1 SV=2 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN]
    soluble fraction [UNKNOWN]
    intracellular [IEA]
    Biological Process: endoplasmic reticulum unfolded protein response [IDA]
    response to vitamin E [UNKNOWN]
    positive regulation of apoptosis [UNKNOWN]
    virus-infected cell apoptosis [IDA]
    protein amino acid autophosphorylation [IDA]
    auxin biosynthetic process [IEA]
    response to lipopolysaccharide [UNKNOWN]
    response to virus [IEA]
    protein amino acid phosphorylation [IDA]
    response to toxin [UNKNOWN]
    translation [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    translation initiation factor activity [IEA]
    RNA binding [IEA]
    protein binding [IPILink to PubMed article]
    double-stranded RNA binding [IEA]
    protein kinase activity [IDA]
    transferase activity [IEA]
    protein serine/threonine kinase activity [IEA]
    kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASDTPGFYM DKLNKYRQMH GVAITYKELS TSGPPHDRRF TFQVLIDEKE FPEAKGRSKQ  60
   61 EARNAAAKLA VDILDNENKV DCHTSASEQG LFVGNYIGLV NSFAQKKKLS VNYEQCEPNS 120
  121 ELPQRFICKC KIGQTMYGTG SGVTKQEAKQ LAAKEAYQKL LKSPPKTAGT SSSVVTSTFS 180
  181 GFSSSSSMTS NGVSQSAPGS FSSENVFTNG LGENKRKSGV KVSPDDVQRN KYTLDARFNS 240
  241 DFEDIEEIGL GGFGQVFKAK HRIDGKRYAI KRVKYNTEKA EHEVQALAEL NHVNIVQYHS 300
  301 CWEGVDYDPE HSMSDTSRYK TRCLFIQMEF CDKGTLEQWM RNRNQSKVDK ALILDLYEQI 360
  361 VTGVEYIHSK GLIHRDLKPG NIFLVDERHI KIGDFGLATA LENDGKSRTR RTGTLQYMSP 420
  421 EQLFLKHYGK EVDIFALGLI LAELLHTCFT ESEKIKFFES LRKGDFSNDI FDNKEKSLLK 480
  481 KLLSEKPKDR PETSEILKTL AEWRNISEKK KRNTC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle