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Protein Overview: HMX2_MOUSE

General Information:
Name(s) found: HMX2_MOUSE [Swiss-Prot]
Description(s) found:
Found 23 descriptions.
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  • Homeobox protein HMX2 OS=Mus musculus GN=Hmx2 PE=2 SV=3 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 273 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: transcription [IEA]
    multicellular organismal development [IEA]
    positive regulation of cell proliferation [IMP]
    inner ear morphogenesis [IGI][IMP]
    nervous system development [IEA]
    cell differentiation [IEA]
    regulation of transcription, DNA-dependent [IEA]
    brain development [IGI]
    regulation of transcription [IEA]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [IEA]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKEDVGKG CPAAGGVSSF TIQSILGGGP SEAPREPAGW PARKRSLSVS SEEEEPEEGW  60
   61 KAPACFCPDP HGPKEPSPKH HTPIPFPCLG TPKGSGGAGP AASERTPFLS PSHPDFKEEK 120
  121 ERLLPAGSPS PGPERPRDGG AERQTGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA 180
  181 CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVGMPL VFRDSSLLRV 240
  241 PVPRSLAFPA PLYYPSSNLS ALPLYNLYNK LDY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] MSA 4.153996 View MSA. No confident structure predictions are available.
    2 View Details [111..273] PSI-BLAST 26.045757 Ultrabithorax (ubx) homeodomain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.20302368446064 bayes_pls_golite062009
  • DNA binding
    		•  3.910335137985 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.70444192553266 bayes_pls_golite062009
  • transcription factor activity
    		•  3.41495638905535 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.0896307866191 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.72533206529661 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.55910796763122 bayes_pls_golite062009
  • transcription activator activity
    		•  1.36535925881104 bayes_pls_golite062009
  • transcription factor binding
    		•  1.05399367242529 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.7265140277161 bayes_pls_golite062009
  • chromatin binding
    		•  0.572427333286789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.49703800163515 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle