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View Structure Prediction Details

Protein: HMX2_MOUSE
Organism: Mus musculus
Length: 273 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMX2_MOUSE.

Description E-value Query
Range
Subject
Range
gi|114633187 - gi|114633187|ref|XP_508091.2| PREDICTED: homeo box (H6 family) 2 [Pan troglodytes]
142.0 [0..1] [273..1]
HMX2 - H6 family homeobox 2
140.0 [0..1] [273..1]
gi|109090824 - gi|109090824|ref|XP_001105231.1| PREDICTED: similar to homeo box (H6 family) 2 [Macaca mulatta]
140.0 [0..1] [273..1]
gi|73998968 - gi|73998968|ref|XP_544055.2| PREDICTED: similar to Homeobox protein HMX2 (Homeobox protein Nkx-5.2) ...
138.0 [0..1] [273..1]
gi|149061281, gi... - gi|157821011|ref|NP_001099773.1| H6 family homeobox 2 [Rattus norvegicus], gi|149061281|gb|EDM11704....
135.0 [0..1] [273..1]
gi|19577382 - gi|19577382|emb|CAD27764.1| putative transcription factor [Anopheles gambiae]
130.0 [0..1] [218..33]
gi|47222353 - gi|47222353|emb|CAG05102.1| unnamed protein product [Tetraodon nigroviridis]
130.0 [0..11] [251..29]
gi|31242161, gi|... - ref|XP_321511.1| ENSANGP00000018171 [Anopheles gambiae], gi|118794479|ref|XP_321511.3| AGAP001593-PA...
AGAP001593-PA - homeobox protein goosecoid|protein_coding|2R:6555150:6556426:-1|gene:AGAP001593
129.0 [0..1] [218..33]
gi|76615429 - gi|76615429|ref|XP_872865.1| PREDICTED: similar to homeobox A7 [Bos taurus]
129.0 [0..16] [209..1]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKEDVGKG CPAAGGVSSF TIQSILGGGP SEAPREPAGW PARKRSLSVS SEEEEPEEGW  60
   61 KAPACFCPDP HGPKEPSPKH HTPIPFPCLG TPKGSGGAGP AASERTPFLS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [111-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSHPDFKEEK ERLLPAGSPS PGPERPRDGG AERQTGAAKK KTRTVFSRSQ VYQLESTFDM  60
   61 KRYLSSSERA CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVGMPL 120
  121 VFRDSSLLRV PVPRSLAFPA PLYYPSSNLS ALPLYNLYNK LDY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.045757
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.20302368446064 bayes_pls_golite062009
DNA binding 3.910335137985 bayes_pls_golite062009
nucleic acid binding 3.70444192553266 bayes_pls_golite062009
transcription factor activity 3.41495638905535 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.0896307866191 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.72533206529661 bayes_pls_golite062009
transcription repressor activity 1.55910796763122 bayes_pls_golite062009
transcription activator activity 1.36535925881104 bayes_pls_golite062009
transcription factor binding 1.05399367242529 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.7265140277161 bayes_pls_golite062009
chromatin binding 0.572427333286789 bayes_pls_golite062009
transcription cofactor activity 0.49703800163515 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle