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Protein Overview: EREG_MOUSE

General Information:
Name(s) found: EREG_MOUSE [Swiss-Prot]
Description(s) found:
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  • pir||S68401 epiregulin precursor - mouse [NCBI NR]
  • gi|6679683|ref|NP_031976.1| epiregulin [Mus musculus] [NCBI NR]
  • gi|25090288|sp|Q61521.1|EREG_MOUSE RecName: Full=Proepiregulin; Contains: RecName: Full=Epiregulin; Short=EPR; Flags: Precursor [NCBI NR]
  • gi|20379851|gb|AAH27838.1| Epiregulin [Mus musculus] [NCBI NR]
  • gi|148673349|gb|EDL05296.1| epiregulin [Mus musculus] [NCBI NR]
  • gi|1255632|dbj|BAA06446.1| epiregulin [Mus musculus] [NCBI NR]
  • Proepiregulin OS=Mus musculus GN=Ereg PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):5-90382439 Epiregulin precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • epiregulin [HMR_022704-rand.fasta]
  • Epiregulin precursor [ipi.MOUSE.v3.06.fasta]
  • epiregulin [Mus musculus]gi|20379851|gb|AAH27838.1| Epiregulin [Mus musculus]gi|25090288|sp|Q61521|EREG_MOUSE Epiregulin precursorgi|7438519|pir||S68401 epiregulin precursor - mousegi|1255632|dbj|BAA06446.1| epiregulin [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Epiregulin precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_007950) epiregulin [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • epiregulin [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Proepiregulin precursor [Contains: Epiregulin (EPR)] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Epiregulin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Ereg Proepiregulin [mouse-ipi-250309-contam.fasta]
  • epiregulin precursor [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Ereg Proepiregulin precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Ereg Epiregulin precursor [zeeyong.fasta]
  • Tax_Id=10090 Gene_Symbol=Ereg Proepiregulin precursor ENSMUSG00000029377 IPI00322480 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • proepiregulin precursor [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00322480.3|SWISS-PROT:Q61521|ENSEMBL:ENSMUSP00000031324|REFSEQ:NP_031976 Tax_Id=10090 Gene_Symbol=Ereg Proepiregulin [ipi.MOUSE.fasta.20090209]
  • Proepiregulin OS=Mus musculus GN=Ereg [011711_HMR.fasta]
  • sp|Q61521|EREG_MOUSE Proepiregulin OS=Mus musculus GN=Ereg PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 162 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    membrane [IEA]
    integral to membrane [IEA]
    extracellular region [IEA]
    plasma membrane [IEA]
    Biological Process: positive regulation of phosphorylation [UNKNOWN][ISS]
    female meiosis [UNKNOWN]
    multicellular organismal development [IEA]
    epidermal growth factor receptor signaling pathway [IDA]
    negative regulation of cell proliferation [IDA]
    positive regulation of cell proliferation [UNKNOWN][IDA]
    positive regulation of DNA replication [UNKNOWN][IDA][ISS]
    positive regulation of interleukin-6 biosynthetic process [IMP]
    anatomical structure morphogenesis [TAS]
    positive regulation of epidermal growth factor receptor activity [UNKNOWN][ISS]
    positive regulation of mitosis [UNKNOWN][IDA][ISS]
    ovarian cumulus expansion [UNKNOWN]
    luteinizing hormone signaling pathway [UNKNOWN]
    organ morphogenesis [TAS]
    positive regulation of smooth muscle cell proliferation [UNKNOWN][ISS]
    oocyte maturation [UNKNOWN]
    positive regulation of cell division [IEA]
    positive regulation of innate immune response [IMP]
    angiogenesis [IEA]
    cytokine-mediated signaling pathway [ISS]
    ovulation [UNKNOWN]
    cell differentiation [IEA]
    positive regulation of cytokine production [IMP]
    primary follicle stage [UNKNOWN]
    Molecular Function: growth factor activity [UNKNOWN]
    epidermal growth factor receptor binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METLPASWVL TLLCLGSHLL QAVISTTVIP SCIPGESEDN CTALVQMEDD PRVAQVQITK  60
   61 CSSDMDGYCL HGQCIYLVDM REKFCRCEVG YTGLRCEHFF LTVHQPLSKE YVALTVILIF 120
  121 LFLIITAGCI YYFCRWYKNR KSKKSREEYE RVTSGDPVLP QV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] PSI-BLAST 13.522879 Solution structure and dynamics of the EGF/TGF-alpha chimera T1E

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • epidermal growth factor receptor binding
    		•  5.06247905565191 bayes_pls_golite062009
  • growth factor activity
    		•  4.72461268561406 bayes_pls_golite062009
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  3.81391812390077 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  3.80413325019921 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.49243532917035 bayes_pls_golite062009
  • heparin binding
    		•  3.18889412817519 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.79319890241656 bayes_pls_golite062009
  • protein binding
    		•  2.77034814417655 bayes_pls_golite062009
  • binding
    		•  2.07793256968292 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.858503860723422 bayes_pls_golite062009
  • transcription factor binding
    		•  0.773938394590729 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.696873990011673 bayes_pls_golite062009
  • protein kinase activity
    		•  0.630643699348945 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.500026173977826 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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