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View Structure Prediction Details

Protein: EREG_MOUSE
Organism: Mus musculus
Length: 162 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EREG_MOUSE.

Description E-value Query
Range
Subject
Range
EREG_RAT - Proepiregulin OS=Rattus norvegicus GN=Ereg PE=1 SV=1
173.0 [0..1] [162..1]
gi|60825082 - gi|60825082|gb|AAX36706.1| epiregulin [synthetic construct]
153.0 [0..1] [162..7]
EREG - epiregulin
152.0 [0..1] [162..7]
gi|114594256 - gi|114594256|ref|XP_001155238.1| PREDICTED: epiregulin [Pan troglodytes]
sp|O14944-1|EREG... - Proepiregulin OS=Homo sapiens GN=EREG PE=1 SV=1 VAR_033827, Proepiregulin OS=Homo sapiens GN=EREG PE...
151.0 [0..1] [162..7]
gi|61833031 - gi|61833031|ref|XP_596732.1| PREDICTED: similar to epiregulin, partial [Bos taurus]
149.0 [0..17] [162..1]
gi|73975403 - gi|73975403|ref|XP_854760.1| PREDICTED: similar to epiregulin [Canis familiaris]
141.0 [0..16] [162..140]
CCDS3564.1_1 - null
gi|109074492 - gi|109074492|ref|XP_001102069.1| PREDICTED: similar to epiregulin precursor [Macaca mulatta]
136.0 [0..1] [162..7]
EPGN_MOUSE - Epigen OS=Mus musculus GN=Epgn PE=2 SV=1
131.0 [0..6] [158..2]
gi|4929183, gi|1... - gi|4929183|gb|AAD33893.1|AF142632_1 cysteine-rich domain neuregulin-1 [Xenopus laevis], gi|148234686...
126.0 [0..2] [146..153]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METLPASWVL TLLCLGSHLL QAVISTTVIP SCIPGESEDN CTALVQMEDD PRVAQVQITK  60
   61 CSSDMDGYCL HGQCIYLVDM REKFCRCEVG YTGLRCEHFF LTVHQPLSKE YVALTVILIF 120
  121 LFLIITAGCI YYFCRWYKNR KSKKSREEYE RVTSGDPVLP QV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1p9jA
Description: Solution structure and dynamics of the EGF/TGF-alpha chimera T1E
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
epidermal growth factor receptor binding 5.06247905565191 bayes_pls_golite062009
growth factor activity 4.72461268561406 bayes_pls_golite062009
receptor binding 4.33045214660893 bayes_pls_golite062009
ErbB-2 class receptor binding 3.81391812390077 bayes_pls_golite062009
ErbB-3 class receptor binding 3.80413325019921 bayes_pls_golite062009
glycosaminoglycan binding 3.49243532917035 bayes_pls_golite062009
heparin binding 3.18889412817519 bayes_pls_golite062009
polysaccharide binding 2.79319890241656 bayes_pls_golite062009
protein binding 2.77034814417655 bayes_pls_golite062009
binding 2.07793256968292 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
transcription regulator activity 0.858503860723422 bayes_pls_golite062009
transcription factor binding 0.773938394590729 bayes_pls_golite062009
transcription cofactor activity 0.696873990011673 bayes_pls_golite062009
protein kinase activity 0.630643699348945 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.500026173977826 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009

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