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Protein Overview: SIA1A_MOUSE

General Information:
Name(s) found: SIA1A_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|6677947|ref|NP_033198.1| seven in absentia 1A [Mus musculus] [NCBI NR]
  • gi|46577317|sp|P61092.1|SIA1A_MOUSE RecName: Full=E3 ubiquitin-protein ligase SIAH1A; AltName: Full=Seven in absentia homolog 1a; Short=Siah-1a; Short=Siah1a; Short=mSiah-1a [NCBI NR]
  • gi|297035|emb|CAA79630.1| siah-1A protein [Mus musculus] [NCBI NR]
  • gi|28277394|gb|AAH46317.1| Seven in absentia 1A [Mus musculus] [NCBI NR]
  • pir||I48763 siah-1A protein - mouse [NCBI NR]
  • E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1 [Swiss-Prot]
  • (P61092) Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):8-86023594 Siah-1A protein [hmr_yeast5_DM3-1_pombe.fasta]
  • seven in absentia 1A [HMR_022704-rand.fasta]
  • Ubiquitin ligase SIAH1A [ipi.MOUSE.v3.06.fasta]
  • seven in absentia 1A [Mus musculus]gi|28277394|gb|AAH46317.1| Seven in absentia 1A [Mus musculus]gi|19550383|gb|AAL91362.1| SIAH-1A [Rattus norvegicus]gi|46577139|sp|Q920M9|SIH1_RAT Ubiquitin ligase SIAH1 (Seven in absentia homolog 1) (Siah-1) (Siah-1a [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Ubiquitin ligase SIAH1A [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_009172) seven in absentia 1A [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • seven in absentia 1A [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • E3 ubiquitin-protein ligase SIAH1A (Seven in absentia homolog 1a) (Siah-1a) (Siah1a) (mSiah-1a) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Seven in absentia 1A [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • siah-1A protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 UBIQUITIN LIGASE SIAH1A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Siah1a E3 ubiquitin-protein ligase SIAH1A [mouse-ipi-250309-contam.fasta]
  • Ubiquitin ligase SIAH1A (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a) [nr-271106-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Siah1a E3 ubiquitin-protein ligase SIAH1A ENSMUSG00000036840 IPI00117790 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • E3 ubiquitin-protein ligase SIAH1A [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00117790.1|SWISS-PROT:P61092|ENSEMBL:ENSMUSP00000044123|REFSEQ:NP_033198 Tax_Id=10090 Gene_Symbol=Siah1a E3 ubiquitin-protein ligase SIAH1A [ipi.MOUSE.fasta.20090209]
  • E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a [011711_HMR.fasta]
  • sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    early endosome [UNKNOWN]
    cytoplasm [IEA]
    synaptic vesicle [UNKNOWN]
    Biological Process: proteasomal ubiquitin-dependent protein catabolic process [IDA]
    regulation of multicellular organism growth [IMP]
    multicellular organismal development [IEA]
    spermatogenesis [IMP]
    male meiosis I [IMP]
    apoptosis [IEA]
    post-embryonic development [IMP]
    cell differentiation [IEA]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [UNKNOWN][IDA]
    cell cycle [IEA]
    protein ubiquitination [IEA]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: ubiquitin-protein ligase activity [UNKNOWN][IDA][TAS]
    zinc ion binding [IDA]
    protein homodimerization activity [IPI]
    protein binding [IPI]
    metal ion binding [IEA]
    ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL  60
   61 VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKAEHEEL 120
  121 CEFRPYSCPC PGASCKWQGS LDAVMPHLMH QHKSITTLQG EDIVFLATDI NLPGAVDWVM 180
  181 MQSCFGFHFM LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP 240
  241 RSIHEGIATA IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] PSI-BLAST 10.0 No description for 2cklB was found.
    2 View Details [97..282] PSI-BLAST 57.0 Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle