Protein Overview: PTC1_MOUSE

General Information:
Name(s) found:	PTC1_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|T30172 transmembrane protein patched - mouse [NCBI NR] gi\|6679519\|ref\|NP_032983.1\| patched [Mus musculus] [NCBI NR] gi\|6225892\|sp\|Q61115.1\|PTC1_MOUSE RecName: Full=Protein patched homolog 1; Short=PTC1; Short=PTC [NCBI NR] gi\|148684273\|gb\|EDL16220.1\| patched homolog 1 [Mus musculus] [NCBI NR] gi\|1181885\|gb\|AAC98798.1\| patched [Mus musculus] [NCBI NR] Protein patched homolog 1 OS=Mus musculus GN=Ptch1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):13-61797437 Patched protein homolog 1 [hmr_yeast5_DM3-1_pombe.fasta] patched; Patched 1; mesenchymal dysplasia [HMR_022704-rand.fasta] Patched protein homolog 1 [ipi.MOUSE.v3.06.fasta] patched [Mus musculus]gi\|1181885\|gb\|AAC98798.1\| patched [Mus musculus]gi\|7513862\|pir\|\|T30172 transmembrane protein patched - mousegi\|6225892\|sp\|Q61115\|PTC1_MOUSE Patched protein homolog 1 (PTC1) (PTC) [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Protein patched homolog 1 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_008957) patched homolog; Patched 1; mesenchymal dysplasia [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] patched [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Tax_Id=10090 Patched protein homolog 1 [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta] Protein patched homolog 1 (PTC1) (PTC) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] patched homolog 1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 PATCHED PROTEIN HOMOLOG 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Ptch1 Protein patched homolog 1 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Ptch1 Protein patched homolog 1 ENSMUSG00000021466 IPI00117758 IPI00551247 [IPIxENS.MOUSE_plus_REVERSE.fasta] protein patched homolog 1 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00117758.1\|SWISS-PROT:Q61115\|TREMBL:Q3LG17;Q3TM50;Q3TQB0;Q3UUD4;Q5R1U4;Q5R252;Q5TLE8\|ENSEMBL:ENSMUSP00000021921\|REFSEQ:NP_032983 Tax_Id=10090 Gene_Symbol=Ptch1 Protein patched homolog 1 [ipi.MOUSE.fasta.20090209] Protein patched homolog 1 OS=Mus musculus GN=Ptch1 [011711_HMR.fasta] Protein patched homolog 1 OS=Mus musculus GN=Ptch1 PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta] sp\|Q61115\|PTC1_MOUSE Protein patched homolog 1 OS=Mus musculus GN=Ptch1 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1434 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [TAS] membrane [IEA] integral to membrane [IEA] extracellular region [TAS] plasma membrane [UNKNOWN]
Biological Process:	dorsal/ventral neural tube patterning [IMP] negative regulation of multicellular organism growth [IMP] keratinocyte proliferation [IMP] signal transduction [IDA] epidermis development [IMP] smoothened signaling pathway [IDA][IGI] pattern specification process [IMP] mammary gland duct morphogenesis [IMP] regulation of growth [IMP] mammary gland epithelial cell differentiation [IMP] organ morphogenesis [IMP] dorsal/ventral pattern formation [IGI] regulation of smoothened signaling pathway [IGI][IMP] embryonic limb morphogenesis [IGI][IMP] neural tube formation [IDA] heart morphogenesis [IMP] mammary gland development [IMP] neural tube closure [IMP] glucose homeostasis [IMP] negative regulation of epithelial cell proliferation [IMP] protein processing [IMP] hindlimb morphogenesis [IMP] response to chlorate [IDA]
Molecular Function:	zinc ion binding [NAS] protein binding [IPI] cholesterol binding [TAS] hedgehog receptor activity [TAS] heparin binding [IDA] receptor activity [IEA] patched binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ ISKGKATGRK  60
   61 APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV GLKAANLETN VEELWVEVGG 120
  121 RVSRELNYTR QKIGEEAMFN PQLMIQTPKE EGANVLTTEA LLQHLDSALQ ASRVHVYMYN 180
  181 RQWKLEHLCY KSGELITETG YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL 240
  241 RWTNFDPLEF LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 300
  301 KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF QLMTPKQMYE 360
  361 HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN STQKVLPFTT TTLDDILKSF 420
  421 SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS 480
  481 FNAATTQVLP FLALGVGVDD VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS 540
  541 NVTAFFMAAL IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 600
  601 TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YTSHSFAHET HITMQSTVQL RTEYDPHTHV 660
  661 YYTTAEPRSE ISVQPVTVTQ DNLSCQSPES TSSTRDLLSQ FSDSSLHCLE PPCTKWTLSS 720
  721 FAEKHYAPFL LKPKAKVVVI LLFLGLLGVS LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ 780
  781 FKYFSFYNMY IVTQKADYPN IQHLLYDLHK SFSNVKYVML EENKQLPQMW LHYFRDWLQG 840
  841 LQDAFDSDWE TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 900
  901 NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP AAEPIEYAQF 960
  961 PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP FLFWEQYISL RHWLLLSISV1020
 1021 VLACTFLVCA VFLLNPWTAG IIVMVLALMT VELFGMMGLI GIKLSAVPVV ILIASVGIGV1080
 1081 EFTVHVALAF LTAIGDKNHR AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA1140
 1141 VLAILTVLGV LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT1200
 1201 NNGSDSSDSE YSSQTTVSGI SEELRQYEAQ QGAGGPAHQV IVEATENPVF ARSTVVHPDS1260
 1261 RHQPPLTPRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP PYRPRRDAFE ISTEGHSGPS1320
 1321 NRDRSGPRGA RSHNPRNPTS TAMGSSVPSY CQPITTVTAS ASVTVAVHPP PGPGRNPRGG1380
 1381 PCPGYESYPE TDHGVFEDPH VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: PTC1_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: