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Protein Overview: NTF3_MOUSE

General Information:
Name(s) found: NTF3_MOUSE [Swiss-Prot]
Description(s) found:
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  • pir||S09155 neurotrophin-3 precursor - mouse [NCBI NR]
  • gi|6679144|ref|NP_032768.1| neurotrophin 3 [Mus musculus] [NCBI NR]
  • gi|53452|emb|CAA37348.1| neurotrophin-3 [Mus musculus] [NCBI NR]
  • gi|41351148|gb|AAH65785.1| Neurotrophin 3 [Mus musculus] [NCBI NR]
  • gi|226819|prf||1607333A neurotrophin 3 [NCBI NR]
  • gi|148667421|gb|EDK99837.1| neurotrophin 3, isoform CRA_b [Mus musculus] [NCBI NR]
  • gi|128582|sp|P20181.1|NTF3_MOUSE RecName: Full=Neurotrophin-3; Short=NT-3; AltName: Full=Neurotrophic factor; AltName: Full=HDNF; AltName: Full=Nerve growth factor 2; Short=NGF-2; Flags: Precursor [NCBI NR]
  • Neurotrophin-3 OS=Mus musculus GN=Ntf3 PE=1 SV=1 [Swiss-Prot]
  • Neurotrophin-3 precursor - Mus musculus (Mouse) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):6-126915160 Neurotrophin-3 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • neurotrophin 3 [HMR_022704-rand.fasta]
  • Neurotrophin-3 precursor [ipi.MOUSE.v3.06.fasta]
  • neurotrophin 3 [Mus musculus]gi|41351148|gb|AAH65785.1| Neurotrophin 3 [Mus musculus]gi|53452|emb|CAA37348.1| neurotrophin-3 [Mus musculus]gi|91142|pir||S09155 neurotrophin-3 precursor - mousegi|128582|sp|P20181|NT3_MOUSE Neurotrophin-3 precursor (NT- [nrdb_11152004_Chlamydomonas]
  • (NM_008742) neurotrophin 3 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • neurotrophin 3 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Tax_Id=10090 Neurotrophin-3 precursor [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta]
  • Neurotrophin-3 precursor (NT-3) (Neurotrophic factor) (HDNF) (Nerve growth factor 2) (NGF-2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • neurotrophin 3, isoform CRA_b [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Neurotrophin 3 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • neurotrophin-3 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 NEUROTROPHIN-3 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Ntf3 Neurotrophin-3 [mouse-ipi-250309-contam.fasta]
  • neurotrophin 3 isoform b [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Ntf3 Neurotrophin-3 precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • neurotrophin-3 isoform b [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00874624.1|SWISS-PROT:P20181|ENSEMBL:ENSMUSP00000052302|REFSEQ:NP_032768 Tax_Id=10090 Gene_Symbol=Ntf3 Neurotrophin-3 [ipi.MOUSE.fasta.20090209]
  • Neurotrophin-3 OS=Mus musculus GN=Ntf3 [011711_HMR.fasta]
  • sp|P20181|NTF3_MOUSE Neurotrophin-3 OS=Mus musculus GN=Ntf3 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [UNKNOWN]
    cytoplasmic membrane-bounded vesicle [IDA]
    extracellular region [UNKNOWN]
    plasma membrane [UNKNOWN]
    Biological Process: neuromuscular synaptic transmission [IDA]
    epidermis development [IMP]
    nervous system development [UNKNOWN]
    positive regulation of glial cell differentiation [UNKNOWN]
    axon guidance [IDA][IMP]
    peripheral nervous system development [IMP]
    myelination [UNKNOWN]
    brain development [IMP]
    neuron development [IMP]
    generation of neurons [IGI]
    glial cell fate determination [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of neuron apoptosis [IDA]
    nerve development [IMP]
    enteric nervous system development [IMP]
    smooth muscle cell differentiation [IMP]
    mechanoreceptor differentiation [IGI]
    regulation of synaptic transmission [UNKNOWN]
    Molecular Function: growth factor activity [IEA]
    protein binding [IPI]
    neurotrophin receptor binding [IEA]
    neurotrophin p75 receptor binding [TAS]
    receptor binding [IEA]
    nerve growth factor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ  60
   61 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 120
  121 EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 180
  181 KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 240
  241 IRIDTSCVCA LSRKIGRT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] MSA 3.055976 View MSA. No confident structure predictions are available.
    2 View Details [135..258] PSI-BLAST 56.0 Neurotrophin 3, NT3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • growth factor activity
    		•  4.74498867224238 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • neurotrophin TRKB receptor binding
    		•  4.62719877337644 bayes_pls_golite062009
  • neurotrophin TRK receptor binding
    		•  4.62719877337644 bayes_pls_golite062009
  • neurotrophin p75 receptor binding
    		•  4.09253117188665 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  3.60727548920187 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  3.46872954776606 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  3.46872954776606 bayes_pls_golite062009
  • protein binding
    		•  3.41839891062651 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  3.16494996397951 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  3.0813162230094 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  2.85718611591787 bayes_pls_golite062009
  • binding
    		•  2.85157432803513 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  2.5098842713893 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49731836866959 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  2.3694685471074 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  2.18218102861024 bayes_pls_golite062009
  • growth factor binding
    		•  2.15782167869238 bayes_pls_golite062009
  • heparin binding
    		•  2.11784489374422 bayes_pls_golite062009
  • hormone activity
    		•  2.10500409590202 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.82426827198541 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.71788348798334 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.377005150119 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.3285764158511 bayes_pls_golite062009
  • signal transducer activity
    		•  1.3285764158511 bayes_pls_golite062009
  • identical protein binding
    		•  1.18858126900765 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  1.18476084022243 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • transcription activator activity
    		•  1.12971001221094 bayes_pls_golite062009
  • collagen binding
    		•  1.00551310632663 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.97031505698447 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • nerve growth factor binding
    		•  0.83909377726083 bayes_pls_golite062009
  • protein kinase activity
    		•  0.81930974773732 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.772832351269279 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.461278618625267 bayes_pls_golite062009
  • kinase activity
    		•  0.457160916814967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.320182329352662 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.137002941165399 bayes_pls_golite062009
  • catalytic activity
    		•  0.105223830172599 bayes_pls_golite062009
  • fibronectin binding
    		•  0.0979012997097199 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle