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Protein Overview: DNMT1_MOUSE

General Information:
Name(s) found: DNMT1_MOUSE [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • DNA (cytosine-5)-methyltransferase 1 OS=Mus musculus GN=Dnmt1 PE=1 SV=5 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 1620 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDA]
    heterochromatin [IDA]
    nucleus [UNKNOWN][IDA]
    cytoplasm [IEA]
    protein complex [UNKNOWN]
    centromeric heterochromatin [IDA]
    Biological Process: chromatin modification [IEA]
    gene silencing [IDA]
    transcription [IEA]
    S-adenosylmethioninamine metabolic process [UNKNOWN]
    S-adenosylmethionine metabolic process [UNKNOWN]
    regulation of transcription [IEA]
    regulation of cell proliferation [IGI]
    DNA methylation [IDA]
    negative regulation of transcription, DNA-dependent [IDA][IMP]
    S-adenosylhomocysteine metabolic process [UNKNOWN]
    regulation of gene expression [IMP]
    DNA methylation on cytosine within a CG sequence [UNKNOWN]
    maintenance of DNA methylation [UNKNOWN][IMP]
    Molecular Function: protein domain specific binding [UNKNOWN]
    zinc ion binding [IDA]
    DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [UNKNOWN]
    double-stranded DNA binding [UNKNOWN]
    unmethylated CpG binding [UNKNOWN]
    methyltransferase activity [IDA]
    transcription factor binding [IEA]
    methyl-CpG binding [UNKNOWN]
    DNA (cytosine-5-)-methyltransferase activity [UNKNOWN][IDA]
    DNA binding [IDA]
    protein binding [IPI]
    metal ion binding [IEA]
    transferase activity [IEA]
    transcription repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVREKLNLLH EFLQTEIKSQ  60
   61 LCDLETKLHK EELSEEGYLA KVKSLLNKDL SLENGTHTLT QKANGCPANG SRPTWRAEMA 120
  121 DSNRSPRSRP KPRGPRRSKS DSDTLSVETS PSSVATRRTT RQTTITAHFT KGPTKRKPKE 180
  181 ESEEGNSAES AAEERDQDKK RRVVDTESGA AAAVEKLEEV TAGTQLGPEE PCEQEDDNRS 240
  241 LRRHTRELSL RRKSKEDPDR EARPETHLDE DEDGKKDKRS SRPRSQPRDP AAKRRPKEAE 300
  301 PEQVAPETPE DRDEDEREEK RRKTTRKKLE SHTVPVQSRS ERKAAQSKSV IPKINSPKCP 360
  361 ECGQHLDDPN LKYQQHPEDA VDEPQMLTSE KLSIYDSTST WFDTYEDSPM HRFTSFSVYC 420
  421 SRGHLCPVDT GLIEKNVELY FSGCAKAIHD ENPSMEGGIN GKNLGPINQW WLSGFDGGEK 480
  481 VLIGFSTAFA EYILMEPSKE YEPIFGLMQE KIYISKIVVE FLQNNPDAVY EDLINKIETT 540
  541 VPPSTINVNR FTEDSLLRHA QFVVSQVESY DEAKDDDETP IFLSPCMRAL IHLAGVSLGQ 600
  601 RRATRRVMGA TKEKDKAPTK ATTTKLVYQI FDTFFSEQIE KYDKEDKENA MKRRRCGVCE 660
  661 VCQQPECGKC KACKDMVKFG GTGRSKQACL KRRCPNLAVK EADDDEEADD DVSEMPSPKK 720
  721 LHQGKKKKQN KDRISWLGQP MKIEENRTYY QKVSIDEEML EVGDCVSVIP DDSSKPLYLA 780
  781 RVTALWEDKN GQMMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYK 840
  841 APSENWAMEG GTDPETTLPG AEDGKTYFFQ LWYNQEYARF ESPPKTQPTE DNKHKFCLSC 900
  901 IRLAELRQKE MPKVLEQIEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKVASPV 960
  961 KRPKKDPVNE TLYPEHYRKY SDYIKGSNLD APEPYRIGRI KEIHCGKKKG KVNEADIKLR1020
 1021 LYKFYRPENT HRSYNGSYHT DINMLYWSDE EAVVNFSDVQ GRCTVEYGED LLESIQDYSQ1080
 1081 GGPDRFYFLE AYNSKTKNFE DPPNHARSPG NKGKGKGKGK GKGKHQVSEP KEPEAAIKLP1140
 1141 KLRTLDVFSG CGGLSEGFHQ AGISETLWAI EMWDPAAQAF RLNNPGTTVF TEDCNVLLKL1200
 1201 VMAGEVTNSL GQRLPQKGDV EMLCGGPPCQ GFSGMNRFNS RTYSKFKNSL VVSFLSYCDY1260
 1261 YRPRFFLLEN VRNFVSYRRS MVLKLTLRCL VRMGYQCTFG VLQAGQYGVA QTRRRAIILA1320
 1321 AAPGEKLPLF PEPLHVFAPR ACQLSVVVDD KKFVSNITRL SSGPFRTITV RDTMSDLPEI1380
 1381 QNGASNSEIP YNGEPLSWFQ RQLRGSHYQP ILRDHICKDM SPLVAARMRH IPLFPGSDWR1440
 1441 DLPNIQVRLG DGVIAHKLQY TFHDVKNGYS STGALRGVCS CAEGKACDPE SRQFSTLIPW1500
 1501 CLPHTGNRHN HWAGLYGRLE WDGFFSTTVT NPEPMGKQGR VLHPEQHRVV SVRECARSQG1560
 1561 FPDSYRFFGN ILDRHRQVGN AVPPPLAKAI GLEIKLCLLS SARESASAAV KAKEEAATKD1620
 1621

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle