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Protein Overview: GCH1_MOUSE

General Information:
Name(s) found: GCH1_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|74220291|dbj|BAE31323.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|6679967|ref|NP_032128.1| GTP cyclohydrolase 1 [Mus musculus] [NCBI NR]
  • gi|47125080|gb|AAH69921.1| GTP cyclohydrolase 1 [Mus musculus] [NCBI NR]
  • gi|462167|sp|Q05915.1|GCH1_MOUSE RecName: Full=GTP cyclohydrolase 1; AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I; Flags: Precursor [NCBI NR]
  • pir||JQ1934 GTP cyclohydrolase I (EC 3.5.4.16) - mouse [NCBI NR]
  • gi|293357|gb|AAA37757.1| GTP cyclohydrolase I [NCBI NR]
  • gi|148688788|gb|EDL20735.1| GTP cyclohydrolase 1 [Mus musculus] [NCBI NR]
  • gi|13542898|gb|AAH05643.1| Gch1 protein [Mus musculus] [NCBI NR]
  • GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):14-38488864 GTP cyclohydrolase I precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • GTP cyclohydrolase 1 [HMR_022704-rand.fasta]
  • GTP cyclohydrolase I precursor [ipi.MOUSE.v3.06.fasta]
  • GTP cyclohydrolase 1 [Mus musculus]gi|47125080|gb|AAH69921.1| GTP cyclohydrolase 1 [Mus musculus]gi|13542898|gb|AAH05643.1| GTP cyclohydrolase 1 [Mus musculus]gi|420207|pir||JQ1934 GTP cyclohydrolase I (EC 3.5.4.16) - mousegi|293357|gb|AAA37757.1| GTP [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 GTP cyclohydrolase I precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_008102) GTP cyclohydrolase 1 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • GTP cyclohydrolase 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • GTP cyclohydrolase 1 precursor (GTP cyclohydrolase I) (GTP-CH-I) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Gch1 protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • GTP cyclohydrolase I [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 GTP CYCLOHYDROLASE I PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Gch1 GTP cyclohydrolase 1 [mouse-ipi-250309-contam.fasta]
  • GTP cyclohydrolase 1 precursor [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Gch1 GTP cyclohydrolase 1 precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • GTP cyclohydrolase I precursor (GTP-CH-I) [nr-271106-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Gch1 GTP cyclohydrolase I precursor [zeeyong.fasta]
  • Tax_Id=10090 Gene_Symbol=Gch1 GTP cyclohydrolase I precursor ENSMUSG00000037580 IPI00114691 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • IPI:IPI00114691.1|SWISS-PROT:Q05915|TREMBL:Q3U7P6;Q3UC70|ENSEMBL:ENSMUSP00000087405|REFSEQ:NP_032128 Tax_Id=10090 Gene_Symbol=Gch1 GTP cyclohydrolase 1 [ipi.MOUSE.fasta.20090209]
  • GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 [011711_HMR.fasta]
  • GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • sp|Q05915|GCH1_MOUSE GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • tr|Q3U7P6|Q3U7P6_MOUSE GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • Isoform of Q05915, GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=1 SV=1 [MOUSE.fasta.20160308]
    • Organism: Mus musculus
    Length: 241 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKPRGVRCT NGFSERELPR PGASPPAEKS RPPEAKGAQP ADAWKAGRHR SEEENQVNLP  60
   61 KLAAAYSSIL LSLGEDPQRQ GLLKTPWRAA TAMQYFTKGY QETISDVLND AIFDEDHDEM 120
  121 VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180
  181 AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240
  241 S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..241] PSI-BLAST 105.0 GTP cyclohydrolase I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTP cyclohydrolase I activity
    		•  5.27071565931386 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  3.66553359909123 bayes_pls_golite062009
  • GTP cyclohydrolase activity
    		•  3.44912994722205 bayes_pls_golite062009
  • 6-pyruvoyltetrahydropterin synthase activity
    		•  2.94513271787536 bayes_pls_golite062009
  • catalytic activity
    		•  2.20788162511962 bayes_pls_golite062009
  • dihydroneopterin aldolase activity
    		•  1.96466418682643 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.73101699306211 bayes_pls_golite062009
  • binding
    		•  1.62520629128577 bayes_pls_golite062009
  • protein binding
    		•  1.34873192832825 bayes_pls_golite062009
  • hydrolase activity
    		•  1.10190985324326 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.974891318710762 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.25616855487144 bayes_pls_golite062009
  • urate oxidase activity
    		•  0.0294957696532921 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle