YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: GCH1_MOUSE
Organism: Mus musculus
Length: 241 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCH1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|74151917 - gi|74151917|dbj|BAE29744.1| unnamed protein product [Mus musculus]
403.0 [0..1] [241..1]
GCH1_RAT - GTP cyclohydrolase 1 OS=Rattus norvegicus GN=Gch1 PE=1 SV=1
401.0 [0..1] [241..1]
gi|255061 - gi|255061|gb|AAB23164.1| GTP cyclohydrolase I [Homo sapiens]
398.0 [0..2] [241..2]
gi|109083691 - gi|109083691|ref|XP_001087365.1| PREDICTED: GTP cyclohydrolase 1 (dopa-responsive dystonia) isoform ...
396.0 [0..2] [241..11]
gi|73963003 - gi|73963003|ref|XP_851883.1| PREDICTED: similar to GTP cyclohydrolase I (GTP-CH-I) isoform 1 [Canis ...
377.0 [0..3] [241..11]
gi|13272331 - gi|13272331|gb|AAK17098.1|AF288421_1 N-terminal truncated GTP cyclohydrolase I [synthetic construct]
349.0 [0..33] [241..2]
GCH1_CHICK - GTP cyclohydrolase 1 OS=Gallus gallus GN=GCH1 PE=2 SV=1
341.0 [0..7] [241..4]

Back

Predicted Domain #1
Region A:
Residues: [1-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKPRGVRCT NGFSERELPR PGASPPAEKS RPPEAKGAQP ADAWKAGRHR SEEENQVNLP  60
   61 KLAAAYSSIL LSLGEDPQRQ GLLKTPWRAA TAMQYFTKGY QETISDVLND AIFDEDHDEM 120
  121 VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180
  181 AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240
  241 S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 1is7A
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 5.27071565931386 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.94513271787536 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
binding 1.62520629128577 bayes_pls_golite062009
protein binding 1.34873192832825 bayes_pls_golite062009
hydrolase activity 1.10190985324326 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
carbon-carbon lyase activity 0.25616855487144 bayes_pls_golite062009
urate oxidase activity 0.0294957696532921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle