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Protein Overview: Dscam-PK

General Information:
Name(s) found: Dscam-PK / FBpp0110380 [FlyBase]
Description(s) found:
Found 9 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 701 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVSQH YEEDIHKAFV IRGNSAILKC DIPSFVADFV NVISWHSDEK 180
  181 ENFYPGTEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVSPQLS GNGNQEHITL TRVPKMGSVT LMCPAQAYPV PFFRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGGRF DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ 480
  481 VGQYVTVNGD VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA 540
  541 IVAGETLIVT CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC 600
  601 VAKNQEGYSA RGSLEVQVMV LPQIVPFAYE DLINMGDSID LFCQIQKGDR PIKVHWSFER 660
  661 SAGDYGFDQV QPQMRTNRIS EKTSMISIPS ASPAHTGRIP V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..141] PSI-BLAST 93.154902 No description for 2v5sA was found.
    2 View Details [142..252] PSI-BLAST 12.221849 Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
    3 View Details [253..620] PSI-BLAST 22.154902 Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
    4 View Details [621..701] FFAS03 3.93 TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • antigen binding
    		•  4.06466268219034 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • receptor activity
    		•  2.6260148704617 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.26083981067854 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • signal transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • peptide antigen binding
    		•  1.32632044811608 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.24415316737453 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • protein binding
    		•  1.17809977833322 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.87238163212 bayes_pls_golite062009
  • receptor binding
    		•  0.838643016003073 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • IgG binding
    		•  0.68435857661103 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.66378995104464 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • protein kinase activity
    		•  0.589015157128768 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.51084773288725 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.5037774536831 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.44769371137055 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.300034766861208 bayes_pls_golite062009
  • protein complex binding
    		•  0.24709070548365 bayes_pls_golite062009
  • kinase activity
    		•  0.232190923918901 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.182775558017364 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.026512949804781 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.00722693352608417 bayes_pls_golite062009
  • structural molecule activity
    		•  0.00139730528977644 bayes_pls_golite062009
    3
    Term Confidence Notes
  • telethonin binding
    		•  6.38949638288343 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.53326178500376 bayes_pls_golite062009
  • actinin binding
    		•  5.48624955510658 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.78053264661873 bayes_pls_golite062009
  • antigen binding
    		•  3.60138508313109 bayes_pls_golite062009
  • binding
    		•  3.05950525762784 bayes_pls_golite062009
  • receptor activity
    		•  2.40849844553572 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.11593100581996 bayes_pls_golite062009
  • signal transducer activity
    		•  2.11593100581996 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.05813971124837 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.54995469932689 bayes_pls_golite062009
  • actin binding
    		•  1.40773197641911 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33341865156235 bayes_pls_golite062009
  • DNA binding
    		•  1.20391708320115 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.19332924581774 bayes_pls_golite062009
  • protein binding
    		•  1.10840622828945 bayes_pls_golite062009
  • peptide antigen binding
    		•  0.972620809539712 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.917911781808094 bayes_pls_golite062009
  • receptor binding
    		•  0.766394469651557 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.727812088393571 bayes_pls_golite062009
  • actin filament binding
    		•  0.684482417673051 bayes_pls_golite062009
  • protein kinase activity
    		•  0.605125585768526 bayes_pls_golite062009
  • transcription factor activity
    		•  0.554724181253623 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.543143020355849 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.485782264748744 bayes_pls_golite062009
  • titin binding
    		•  0.395513709080215 bayes_pls_golite062009
  • IgG binding
    		•  0.33386837457402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.328985661202282 bayes_pls_golite062009
  • kinase activity
    		•  0.268573733052192 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.232427547336012 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.232191642090185 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.229394368927229 bayes_pls_golite062009
  • protein complex binding
    		•  0.0847341919733864 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0426518119496661 bayes_pls_golite062009
    4
    Term Confidence Notes
  • telethonin binding
    		•  6.38949638288343 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.53326178500376 bayes_pls_golite062009
  • actinin binding
    		•  5.48624955510658 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.78053264661873 bayes_pls_golite062009
  • antigen binding
    		•  3.60138508313109 bayes_pls_golite062009
  • binding
    		•  3.05950525762784 bayes_pls_golite062009
  • receptor activity
    		•  2.40849844553572 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.11593100581996 bayes_pls_golite062009
  • signal transducer activity
    		•  2.11593100581996 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.05813971124837 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.54995469932689 bayes_pls_golite062009
  • actin binding
    		•  1.40773197641911 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33341865156235 bayes_pls_golite062009
  • DNA binding
    		•  1.20391708320115 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.19332924581774 bayes_pls_golite062009
  • protein binding
    		•  1.10840622828945 bayes_pls_golite062009
  • peptide antigen binding
    		•  0.972620809539712 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.917911781808094 bayes_pls_golite062009
  • receptor binding
    		•  0.766394469651557 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.727812088393571 bayes_pls_golite062009
  • actin filament binding
    		•  0.684482417673051 bayes_pls_golite062009
  • protein kinase activity
    		•  0.605125585768526 bayes_pls_golite062009
  • transcription factor activity
    		•  0.554724181253623 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.543143020355849 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.485782264748744 bayes_pls_golite062009
  • titin binding
    		•  0.395513709080215 bayes_pls_golite062009
  • IgG binding
    		•  0.33386837457402 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.328985661202282 bayes_pls_golite062009
  • kinase activity
    		•  0.268573733052192 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.232427547336012 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.232191642090185 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.229394368927229 bayes_pls_golite062009
  • protein complex binding
    		•  0.0847341919733864 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0426518119496661 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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