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Protein Overview: Nipped-B-PE, Nip...

General Information:
Name(s) found: Nipped-B-PE / FBpp0110411 [FlyBase]
Nipped-B-PF / FBpp0110410 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Nipped-B is referred to in FlyBase by the symbol Dmel\Nipped-B (CG17704, FBgn0026401). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:579177..616515. It has the cytological map location 41B3-41C1. There is experimental evidence that it has the molecular function</span>: transcription activator activity. There is experimental evidence that it is involved in the biological process</span>: mitotic sister chromatid cohesion; regulation of transcription, DNA-dependent. 11 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene Nipped-B is referred to in FlyBase by the symbol Dmel\Nipped-B (CG17704, FBgn0026401). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:579177..616515. It has the cytological map location 41B3-41C1. There is experimental evidence that it has the molecular function</span>: transcription activator activity. There is experimental evidence that it is involved in the biological process</span>: mitotic sister chromatid cohesion; regulation of transcription, DNA-dependent. 11 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2077 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cohesin complex [IDA]
    protein complex [IDA]
    synaptonemal complex [IDA]
    Biological Process: positive regulation of gene expression [IGI][IMP]
    mitotic sister chromatid cohesion [IMP]
    regulation of transcription, DNA-dependent [IMP]
    Molecular Function: transcription activator activity [IMP]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGERDNPTVP VTTLAGLTST SDLLSELPVA DSLQSAASLN KSLLFHALVA NESSNLLSMR  60
   61 NENLVRQLVT AIERTNSDNI ELIHCPVQDT ATNCSTYPEL LQGIYHFRPA VFNTSIKIHS 120
  121 PDQHTANARL EAKKMQIDSY SIPECYASPT NLSISNEHQL QDAQACFNQL TSMTSKEILE 180
  181 EFSQINFKEN ATEKDKIDVI ENSDLNVTKI LSQNTLKKKS NTPERSTVQS IQEQFFIQQQ 240
  241 EANYNLKHDL NQVSTNVGQI QNISDTFPQE PSNFNLNSVN IPNMLYVQSP PFTESEPTQA 300
  301 HHSSIEYLKK KKSQILDVSI LNRQQVLENT SLHIINKSST YQTNQNVSTT TSTSTSSSGK 360
  361 SQVRVCINRL SIEDSRLMQQ SIKKFVQKSP ELARSMGLLQ ETCQQQHENL NIIPTSAEEC 420
  421 VLESRASSTN NTVKIPIDTF STIKADEKRS AKRKLAISIG DIPPEQIFSK PKMRRVERIT 480
  481 PLSNTKCVKE EVTRSQTYQQ FIRNMDHIIE ILDDSESPNF DSEDVDETIE CISSKLLNSM 540
  541 STDVAKLKAK QALDSIPKNK LTLLINYAMR NVYLARNYFA GTEDEDEFVD DEVIEKLLNA 600
  601 MDACLLICNI YSTVSDLQFL QEDNVSHIIK FTQFQLRETI FPLHDPVYTA KSIKRTTHRK 660
  661 KIKSHQAQNR SMQLFYLKTV ELLKVFVTLF DKCVFVDTIV LPLSTLAIEP FFVDNIETLQ 720
  721 FVCLELVTTI FRKERYDKIR NSILGDILTS IDRLPSSKKN LRPYKLTNNG GNIQMVTALV 780
  781 LQLIQCATIL PDSLCDNGKF SNKPQEGNTF DEEGKKLLQP SQDLLVLQKY DVAVSIGGNF 840
  841 LTTFLNKCKS RSNETDFRPL FENFIHDLLA TVNKPEWPAS ELLLSLLGTM LVRYVSDKGI 900
  901 EQSIRLVSLD YLGIVAARLR KDTVESRCRV NIIDSMIQSI KLEQEKEGDV TSNNDQFDLE 960
  961 PEEQRTDFLQ KILLDFLAVN AQEENLIWDY ARHFYLAQWY RDVIYQRRRI NDGKKGLAFR1020
 1021 KSKIRNNRRT NGDYLDTSDS GSCDESDTDT NKKRIHCVDS NDFELNINIY KALEARKQYF1080
 1081 INKIKPFSVF GEQNHSSNQH IKTYIDYNNA QLIAQYLATK RPFSQSFDGC LKKIILVVNE1140
 1141 PSIAVRTRAM KCLANIVEVD PLVLKRKDMQ MGVNQKFLDT AISVREAAVD LVGKFVLSNQ1200
 1201 DLIDQYYDML STRILDTGVS VRKRVIKILR DICLEYPDFS KIPEICVKMI RRVHDEEGIQ1260
 1261 KLVTEVFMKM WFTPCTKNDK IGIQRKINHI IDVVNTAHDT GTTWLEGLLM SIFKPRDNML1320
 1321 RSEGCVQEFI KKNSEPPMDI VIACQQLADG LVDRLIELED TDNSRMLGCI TTLHLLAKVR1380
 1381 PQLLVKHAIT IEPYLNIKCH SATAAKFICA VADILEKVVP LVNNASESFL ASLEEHLMLL1440
 1441 VVSRNQAEVT SCVSCLGALV NKITHNFKLI RDCFQKFYRV LDVSRSQVIQ GNNSVDNIYT1500
 1501 PSFRRSLFTI GILMRYFDFK SPIALGETND GLPVSICEDV FHCLMFFCRC TNQEIRKQAL1560
 1561 ISLGSFCVLN DGYLTRSELK NLYCEILSSI ANDAGFKIIC MRNIWIYLTE SEMFMHNKEK1620
 1621 EWEKQSKHED LKEMNDVSSG MASRIIQLYL EEILECFLNR DDTVRLWAVK VIQIVLRQGL1680
 1681 VHPVRMVPYL ICLSTDHRIE SAHRADALLK DIDKTYSGFV NMKVQFGLQL CFKLQKILQI1740
 1741 NNRGKLEIIR GYASRGPDNT TTALNDFLYT LLRTTKPQRR ALVQTVTKQF DDQKTSLQQM1800
 1801 LYIADNLAYF PYVVQDEPLY LIHQIDLLIS MAGTHLLATF KEHIKPSDKE GDVLEDDDDV1860
 1861 EDPEVLFNRL PEDLTEIIKC ITSAQACMLL LILKDHLKEM YAITDSKISR YSPSEQKLYE1920
 1921 KAVTRKSVND FNPKTTIDVI KKQMSQEKLS TDINFTLTKE EKLDLVVKYL DFKQLMLKLD1980
 1981 PDDGDSDADE SRDKTMLNIS ASSDGVAFSS SAKNSHSACD GYSLTVTDVV DVPMSHIAKA2040
 2041 SMLTSKPSGR KTNPVRTKKK RRKIDSTDDE TSDAEYA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] MSA 1.405991 View MSA. No confident structure predictions are available.
    2 View Details [175..362] PSI-BLAST 6.69897 Sec24
    3 View Details [363..471] deduced N/A No confident structure predictions are available.
    4 View Details [472..532] deduced N/A No confident structure predictions are available.
    5 View Details [533..767] deduced N/A No confident structure predictions are available.
    6 View Details [768..959] deduced N/A No confident structure predictions are available.
    7 View Details [960..1045] deduced N/A No confident structure predictions are available.
    8 View Details [1046..1866] FFAS03 2.23 Adaptin beta subunit N-terminal fragment
    9 View Details [1867..2077] MSA 1.047961 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69616509670156 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.19067997822967 bayes_pls_golite062009
  • DNA binding
    		•  1.96172460362671 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21493607378314 bayes_pls_golite062009
  • RNA binding
    		•  0.243875756041061 bayes_pls_golite062009
  • transcription activator activity
    		•  0.142253868848261 bayes_pls_golite062009
  • transcription factor binding
    		•  8.79739237675814E-4 bayes_pls_golite062009
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle