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View Structure Prediction Details

Protein: Nipped-B-PE, Nip...
Organism: Drosophila melanogaster
Length: 2077 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Nipped-B-PE, Nip....

Description E-value Query
Range
Subject
Range
gi|50400943, gi|... - gi|50400943|sp|Q7PLI2|NIPB_DROME Nipped-B protein (SCC2 homolog), gi|33088246|gb|AAD26161.2|AF114160...
2089.0 [0..1] [2077..1]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGERDNPTVP VTTLAGLTST SDLLSELPVA DSLQSAASLN KSLLFHALVA NESSNLLSMR  60
   61 NENLVRQLVT AIERTNSDNI ELIHCPVQDT ATNCSTYPEL LQGIYHFRPA VFNTSIKIHS 120
  121 PDQHTANARL EAKKMQIDSY SIPECYASPT NLSISNEHQL QDAQACFNQL TSMT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [175-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEILEEFSQ INFKENATEK DKIDVIENSD LNVTKILSQN TLKKKSNTPE RSTVQSIQEQ  60
   61 FFIQQQEANY NLKHDLNQVS TNVGQIQNIS DTFPQEPSNF NLNSVNIPNM LYVQSPPFTE 120
  121 SEPTQAHHSS IEYLKKKKSQ ILDVSILNRQ QVLENTSLHI INKSSTYQTN QNVSTTTSTS 180
  181 TSSSGKSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [363-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRVCINRLSI EDSRLMQQSI KKFVQKSPEL ARSMGLLQET CQQQHENLNI IPTSAEECVL  60
   61 ESRASSTNNT VKIPIDTFST IKADEKRSAK RKLAISIGDI PPEQIFSKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [472-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMRRVERITP LSNTKCVKEE VTRSQTYQQF IRNMDHIIEI LDDSESPNFD SEDVDETIEC  60
   61 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [533-767]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKLLNSMST DVAKLKAKQA LDSIPKNKLT LLINYAMRNV YLARNYFAGT EDEDEFVDDE  60
   61 VIEKLLNAMD ACLLICNIYS TVSDLQFLQE DNVSHIIKFT QFQLRETIFP LHDPVYTAKS 120
  121 IKRTTHRKKI KSHQAQNRSM QLFYLKTVEL LKVFVTLFDK CVFVDTIVLP LSTLAIEPFF 180
  181 VDNIETLQFV CLELVTTIFR KERYDKIRNS ILGDILTSID RLPSSKKNLR PYKLT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [768-959]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNGGNIQMVT ALVLQLIQCA TILPDSLCDN GKFSNKPQEG NTFDEEGKKL LQPSQDLLVL  60
   61 QKYDVAVSIG GNFLTTFLNK CKSRSNETDF RPLFENFIHD LLATVNKPEW PASELLLSLL 120
  121 GTMLVRYVSD KGIEQSIRLV SLDYLGIVAA RLRKDTVESR CRVNIIDSMI QSIKLEQEKE 180
  181 GDVTSNNDQF DL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [960-1045]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPEEQRTDFL QKILLDFLAV NAQEENLIWD YARHFYLAQW YRDVIYQRRR INDGKKGLAF  60
   61 RKSKIRNNRR TNGDYLDTSD SGSCDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1046-1866]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDTDTNKKRI HCVDSNDFEL NINIYKALEA RKQYFINKIK PFSVFGEQNH SSNQHIKTYI  60
   61 DYNNAQLIAQ YLATKRPFSQ SFDGCLKKII LVVNEPSIAV RTRAMKCLAN IVEVDPLVLK 120
  121 RKDMQMGVNQ KFLDTAISVR EAAVDLVGKF VLSNQDLIDQ YYDMLSTRIL DTGVSVRKRV 180
  181 IKILRDICLE YPDFSKIPEI CVKMIRRVHD EEGIQKLVTE VFMKMWFTPC TKNDKIGIQR 240
  241 KINHIIDVVN TAHDTGTTWL EGLLMSIFKP RDNMLRSEGC VQEFIKKNSE PPMDIVIACQ 300
  301 QLADGLVDRL IELEDTDNSR MLGCITTLHL LAKVRPQLLV KHAITIEPYL NIKCHSATAA 360
  361 KFICAVADIL EKVVPLVNNA SESFLASLEE HLMLLVVSRN QAEVTSCVSC LGALVNKITH 420
  421 NFKLIRDCFQ KFYRVLDVSR SQVIQGNNSV DNIYTPSFRR SLFTIGILMR YFDFKSPIAL 480
  481 GETNDGLPVS ICEDVFHCLM FFCRCTNQEI RKQALISLGS FCVLNDGYLT RSELKNLYCE 540
  541 ILSSIANDAG FKIICMRNIW IYLTESEMFM HNKEKEWEKQ SKHEDLKEMN DVSSGMASRI 600
  601 IQLYLEEILE CFLNRDDTVR LWAVKVIQIV LRQGLVHPVR MVPYLICLST DHRIESAHRA 660
  661 DALLKDIDKT YSGFVNMKVQ FGLQLCFKLQ KILQINNRGK LEIIRGYASR GPDNTTTALN 720
  721 DFLYTLLRTT KPQRRALVQT VTKQFDDQKT SLQQMLYIAD NLAYFPYVVQ DEPLYLIHQI 780
  781 DLLISMAGTH LLATFKEHIK PSDKEGDVLE DDDDVEDPEV L

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.23
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.96084803796407 bayes_pls_golite062009
nucleic acid binding 2.69616509670156 bayes_pls_golite062009
transcription regulator activity 2.19067997822967 bayes_pls_golite062009
DNA binding 1.96172460362671 bayes_pls_golite062009
protein binding 1.61131270705552 bayes_pls_golite062009
transcription factor activity 1.21493607378314 bayes_pls_golite062009
RNA binding 0.243875756041061 bayes_pls_golite062009
transcription activator activity 0.142253868848261 bayes_pls_golite062009
transcription factor binding 8.79739237675814E-4 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1867-2077]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNRLPEDLTE IIKCITSAQA CMLLLILKDH LKEMYAITDS KISRYSPSEQ KLYEKAVTRK  60
   61 SVNDFNPKTT IDVIKKQMSQ EKLSTDINFT LTKEEKLDLV VKYLDFKQLM LKLDPDDGDS 120
  121 DADESRDKTM LNISASSDGV AFSSSAKNSH SACDGYSLTV TDVVDVPMSH IAKASMLTSK 180
  181 PSGRKTNPVR TKKKRRKIDS TDDETSDAEY A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle