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Protein Overview: HSPA2

General Information:
Name(s) found: HSPA2 [HGNC (HUGO)]
Description(s) found:
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  • gi|92918931|gb|ABE96830.1| heat shock 70kDa protein 2 [Homo sapiens] [NCBI NR]
  • gi|476705|gb|AAA52698.1| heat shock protein [Homo sapiens] [NCBI NR]
  • gi|32879973|gb|AAP88817.1| heat shock 70kDa protein 2 [Homo sapiens] [NCBI NR]
  • gi|1708307|sp|P54652.1|HSP72_HUMAN RecName: Full=Heat shock-related 70 kDa protein 2; Short=Heat shock 70 kDa protein 2 [NCBI NR]
  • gi|13676857|ref|NP_068814.2| heat shock 70kDa protein 2 [Homo sapiens] [NCBI NR]
  • gi|12804655|gb|AAH01752.1| Heat shock 70kDa protein 2 [Homo sapiens] [NCBI NR]
  • gi|119601271|gb|EAW80865.1| heat shock 70kDa protein 2, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119601270|gb|EAW80864.1| heat shock 70kDa protein 2, isoform CRA_a [Homo sapiens] [NCBI NR]
  • pir||A55719 dnaK-type molecular chaperone HSPA2 - human [NCBI NR]
  • heat shock 70kDa protein 2 [HGNC (HUGO)]
  • Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 PE=1 SV=1 [Swiss-Prot]
  • (P54652) Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) [Swiss-Prot]
  • Heat shock-related 70 kDa protein 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • heat shock 70kDa protein 2; heat shock 70kD protein 2; Heat-shock 70kD protein-2 [HMR_022704.fasta]
  • heat shock 70kDa protein 2; Heat-shock 70kD protein-2; heat shock 70kD protein 2 [071204_hmrz_cont.fasta]
  • heat shock 70kDa protein 2 [Homo sapiens]gi|32879973|gb|AAP88817.1| heat shock 70kDa protein 2 [Homo sapiens]gi|12804655|gb|AAH01752.1| Heat shock 70kDa protein 2 [Homo sapiens]gi|1708307|sp|P54652|HS72_HUMAN Heat shock-related 70 kDa protein 2 (Heat s [nrdb_11152004_Chlamydomonas]
  • Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Heat shock-related 70 kDa protein 2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_021979) heat shock 70kD protein 2; Heat-shock 70kD protein-2 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • heat shock 70kDa protein 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • heat shock 70kDa protein 2; Heat-shock 70kD protein-2; heat shock 70kD protein 2 [Homo sapiens] [HumanGallus06162005.fasta]
  • heat shock 70kDa protein 2; heat shock 70kD protein 2; Heat-shock 70kD protein-2 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Tax_Id=9606 Heat shock-related 70 kDa protein 2 [EBI-IPI_Drosophila_na_12-13-2007_con_reversed.fasta]
  • heat shock 70kDa protein 2, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Heat shock 70kDa protein 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • heat shock protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HEAT SHOCK-RELATED 70 KDA PROTEIN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HSPA2 Heat shock-related 70 kDa protein 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00007702.1|SWISS-PROT:P54652|ENSEMBL:ENSP00000247207;ENSP00000378199|REFSEQ:NP_068814|H-INV:HIT000030626|VEGA:OTTHUMP00000028319;OTTHUMP00000180664 Tax_Id=9606 Gene_Symbol=HSPA2 Heat shock-related 70 kDa protein 2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=HSPA2 Heat shock-related 70 kDa protein 2 ENSG00000126803 IPI00007702 [drosphohumanreversed.fasta]
  • heat shock-related 70 kDa protein 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P54652;Q15508;Q53XM3;Q9UE78; RecName: Full=Heat shock-related 70 kDa protein 2; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Heat shock-related 70 kDa protein 2 OS=Homo sapiens GN=HSPA2 [011711_HMR.fasta]
  • GeneSymbol=HSPA2 Synonyms=HSP70-2|HSP70-3 heat shock-related 70 kDa protein 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00007702.1|SWISS-PROT:P54652|ENSEMBL:ENSP00000247207;ENSP00000378199|REFSEQ:NP_068814|H-INV:HIT000030626|VEGA:OTTHUMP00000180664 Tax_Id=9606 Gene_Symbol=HSPA2 Heat shock-related 70 kDa protein 2 [ipi.HUMAN.20110912.fasta]
  • Heat shock-related 70 kDa protein 2 GN=HSPA2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Heat shock 70kDa protein 2, isoform CRA_a OS=Homo sapiens GN=HSPA2 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 639 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV  60
   61 AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI 120
  121 SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA 180
  181 AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM 240
  241 VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI 300
  301 TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK 360
  361 ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN 420
  421 TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT 480
  481 FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA 540
  541 AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK 600
  601 ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CENPA No Comments Foltz DR, et al (2006)
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)
    View Run None Entered Sample pIC146 from april 2005 Okada, M., et al. (2006)
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..563] PSI-BLAST 1000.0 crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
    2 View Details [564..639] PSI-BLAST 60.0 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.97191512372019 bayes_pls_golite062009
  • structural molecule activity
    		•  3.59589495899762 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • hydrolase activity
    		•  1.88613511243568 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.53527958884988 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.186218331473028 bayes_pls_golite062009
  • chromatin binding
    		•  0.155140608043269 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle