Protein Overview: RB_RAT

General Information:
Name(s) found:	RB_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|109501744\|ref\|XP_344435.3\| PREDICTED: similar to Retinoblastoma-associated protein (PP105) (RB) [Rattus norvegicus] [NCBI NR] Retinoblastoma-associated protein OS=Rattus norvegicus GN=Rb1 PE=1 SV=3 [Swiss-Prot] Tax_Id=10116 PREDICTED: retinoblastoma 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] PREDICTED: similar to Retinoblastoma-associated protein (PP105) (RB) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Rb1 similar to Retinoblastoma-associated protein [rat-ipi-250309-contam.fasta] Retinoblastoma-associated protein OS=Rattus norvegicus GN=Rb1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	920 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IDA][ISS] transcription factor complex [UNKNOWN][IEA] PML body [UNKNOWN][ISS] spindle [UNKNOWN][IEA] nucleoplasm [UNKNOWN]
Biological Process:	cell cycle arrest [UNKNOWN][IEA] chromatin modification [IEA] negative regulation of cell proliferation [UNKNOWN][IEA] myoblast differentiation [UNKNOWN][ISS] negative regulation of cell cycle [UNKNOWN][IEA] enucleate erythrocyte differentiation [UNKNOWN][IEA] Ras protein signal transduction [UNKNOWN][IEA] regulation of transcription [IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] negative regulation of protein kinase activity [UNKNOWN][ISS] negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] cell division [UNKNOWN][IEA] striated muscle cell differentiation [UNKNOWN][IEA] negative regulation of transcription, DNA-dependent [UNKNOWN] positive regulation of macrophage differentiation [UNKNOWN][IEA] negative regulation of transcription [UNKNOWN] regulation of lipid kinase activity [UNKNOWN][ISS] G1/S transition of mitotic cell cycle [UNKNOWN][IEA] regulation of cell cycle [UNKNOWN]
Molecular Function:	DNA binding [IEA] protein binding [UNKNOWN][IPI] ubiquitin protein ligase binding [UNKNOWN][IEA] phosphoprotein binding [UNKNOWN][IEA] transcription factor binding [UNKNOWN][ISS] transcription repressor activity [UNKNOWN][IEA] kinase binding [UNKNOWN][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKAPRRTA AAEPPPPPPP PPEDDPAQDS DPEELPLIRL EFEKIEEPEF IALCQKLKVP  60
   61 DHVRERAWLT WEKVSSVDGI LEGYIQKKKE LWGICIFIAA VDLDEMPFTF TELQKSIETS 120
  121 VYKFFDLLKE IDTSTKVDNA VSRLLKKYNV LCALYSKLER TCGLIYLTQP SSGLSTEINS 180
  181 MLVLKVSWIT FLLAKGEVVQ MEDDLVISFQ LMLCVLDYFI KLSPPALLRE PYKTAATPIN 240
  241 GSPRTPRRGQ NRSARIAKQL ESDTRTIEVL CKEHECNVDE VKNVYFKNFI PFISSLGIVS 300
  301 SNGLPELESL SKRYEEVYLK SKDLDARLFL DHDKTLQTDT IDSFETERTP RKSNPDEEAN 360
  361 MVTPHTPVRT VMNTIQQLMV ILNSASDQPS ENLISYFSNC TVNPKENILK RVKDVGHIFK 420
  421 EKFASAVGQG CIDIGAQRYK LGVRLYYRVM ESMLKSEEER LSIQNFSKLL NDNIFHMSLL 480
  481 ACALEVVMAT YSRSMLQNLD SGTDLSFPWI LNVLNLKAFD FYKVIESFIK VEANLTREMI 540
  541 KHLERCEHRI MESLAWLSDS PLFDLIKQSK DGEGPDHLES ACSLSLPLQS NHTAADMYLS 600
  601 PIRSPKKRTS TTRVNSAANT ETQAASAFHT QKPLKSTSLS LFYKKVYRLA YLRLNTLCAR 660
  661 LLSDHPELEH IIWTLFQHTL ENEYELMKDR HLDQIMMCSM YGICKVKNID LKFKIIVTAY 720
  721 KDLPHAAQET FKRVLIREEE FDSIIVFYNS VFMQRLKTNI LQYASTRPPT LSPIPHIPRS 780
  781 PYKFSSSPLR IPGGNIYISP LKSPYKISEG LPTPTKMTPR SRILVSIGES FGTSEKFQKI 840
  841 NQMVCNSDRV LKRSAEGGNP PKPLKKLRFD IEGSDEADGS KHLPAESKFQ QKLAEMTSTR 900
  901 TRMQKQKLND SMEISNKEEK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: RB_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: