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Protein Overview: PDHA2

General Information:
Name(s) found: PDHA2 [HGNC (HUGO)]
Description(s) found:
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  • pir||DEHUPT pyruvate dehydrogenase (lipoamide) (EC 1.2.4.1) alpha chain precursor, testis-specific - human [NCBI NR]
  • gi|4885543|ref|NP_005381.1| pyruvate dehydrogenase E1 alpha 2 [Homo sapiens] [NCBI NR]
  • gi|266687|sp|P29803.1|ODPAT_HUMAN RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; AltName: Full=PDHE1-A type II; Flags: Precursor [NCBI NR]
  • gi|190790|gb|AAA60232.1| pyruvate dehydrogenase complex [Homo sapiens] [NCBI NR]
  • gi|189066860|dbj|BAG36600.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|133777220|gb|AAH30697.3| Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI NR]
  • gi|121934212|gb|AAI27638.1| Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI NR]
  • gi|121934094|gb|AAI27639.1| Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI NR]
  • gi|111185648|gb|AAI19658.1| Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI NR]
  • gi|111185646|gb|AAI19657.1| Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI NR]
  • pyruvate dehydrogenase (lipoamide) alpha 2 [HGNC (HUGO)]
  • (P29803) Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II) [Swiss-Prot]
  • Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Homo sapiens GN=PDHA2 PE=1 SV=1 [Swiss-Prot]
  • Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase, E1-alpha polypeptide, testis specific [HMR_022704.fasta]
  • pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens]gi|266687|sp|P29803|ODPT_HUMAN Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (PDHE1-A type II)gi|66038|pir||DEHUPT pyruvate dehydrogenase (lipoam [nrdb_11152004_Chlamydomonas]
  • Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (PDHE1-A type II) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005390) pyruvate dehydrogenase (lipoamide) alpha 2; Pyruvate dehydrogenase, E1-alpha polypeptide, testis specific [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase, E1-alpha polypeptide, testis specific [Homo sapiens] [HumanGallus06162005.fasta]
  • Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor (PDHE1-A type II) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Pyruvate dehydrogenase (lipoamide) alpha 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • pyruvate dehydrogenase complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [human-ipi-250309-contam.fasta]
  • pyruvate dehydrogenase E1 alpha 2 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • pyruvate dehydrogenase E1 alpha 2 precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00024087.3|SWISS-PROT:P29803|ENSEMBL:ENSP00000295266|REFSEQ:NP_005381|H-INV:HIT000041106|VEGA:OTTHUMP00000161620 Tax_Id=9606 Gene_Symbol=PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PDHA2 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor ENSG00000163114 IPI00024087 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PDHA2 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P29803;B2R9Q3;Q0VDI5;Q4VC02;Q6NXQ1; RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; AltName: Full=PDHE1-A type II; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial OS=Homo sapiens GN=PDHA2 [011711_HMR.fasta]
  • GeneSymbol=PDHA2 Synonyms=MGC149517|MGC149518|PDHAL pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial GN=PDHA2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 388 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAAFISRVL RRVAQKSARR VLVASRNSSN DATFEIKKCD LYLLEEGPPV TTVLTRAEGL  60
   61 KYYRMMLTVR RMELKADQLY KQKFIRGFCH LCDGQEACCV GLEAGINPSD HVITSYRAHG 120
  121 VCYTRGLSVR SILAELTGRR GGCAKGKGGS MHMYTKNFYG GNGIVGAQGP LGAGIALACK 180
  181 YKGNDEICLT LYGDGAANQG QIAEAFNMAA LWKLPCVFIC ENNLYGMGTS TERAAASPDY 240
  241 YKRGNFIPGL KVDGMDVLCV REATKFAANY CRSGKGPILM ELQTYRYHGH SMSDPGVSYR 300
  301 TREEIQEVRS KRDPIIILQD RMVNSKLATV EELKEIGAEV RKEIDDAAQF ATTDPEPHLE 360
  361 ELGHHIYSSD SSFEVRGANP WIKFKSVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 90.30103 E1-beta subunit of pyruvate dehydrogenase (PP module)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  11.3856674722026 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  11.0549577473177 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  10.8180381281695 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  7.00951713446616 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  6.25236550086321 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.89064211833637 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  4.51986503762195 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  3.8269109174531 bayes_pls_golite062009
  • 2-oxoisovalerate dehydrogenase (acylating) activity
    		•  3.00128844859152 bayes_pls_golite062009
  • cyclin-dependent protein kinase 5 activator regulator activity
    		•  3.00128844859152 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.85833680148029 bayes_pls_golite062009
  • transketolase activity
    		•  1.58421424158131 bayes_pls_golite062009
  • protein binding
    		•  0.992849906276347 bayes_pls_golite062009
  • binding
    		•  0.750068469698571 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  0.667418924427388 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle