YRC Public Data Repository - Protein Structure Prediction

Protein:	PDHA2
Organism:	Homo sapiens
Length:	388 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDHA2.

Description	E-value	Query Range	Subject Range
gi\|66267554, gi\|... - gi\|66267554\|gb\|AAH94760.1\| PDHA2 protein [Homo sapiens], gi\|34192185\|gb\|AAH30697.2\| PDHA2 protein [H...	0.0	[1..388]	[20..407]
gi\|55622948 - gi\|55622948\|ref\|XP_526637.1\| PREDICTED: pyruvate dehydrogenase (lipoamide) alpha 2 [Pan troglodytes]	0.0	[1..388]	[54..441]
gi\|74006561 - gi\|74006561\|ref\|XP_537975.2\| PREDICTED: similar to Pyruvate dehydrogenase E1 component alpha subunit...	0.0	[2..388]	[4..390]
ODPA_BOVIN - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Bos taurus GN=PDHA...	0.0	[2..388]	[4..390]
gi\|57657 - gi\|57657\|emb\|CAA78146.1\| pyruvate dehydrogenase E1 alpha form 1 subunit [Rattus rattus] gi\|66035 - pir\|\|DERTP1 pyruvate dehydrogenase (lipoamide) (EC 1.2.4.1) alpha chain 1 precursor - rat	0.0	[2..388]	[4..390]
ODPA_MOUSE - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus GN=Pd...	0.0	[2..388]	[4..390]
gi\|71051030, gi\|... - gi\|71051030\|gb\|AAH98897.1\| Pyruvate dehydrogenase (lipoamide) alpha 1 [Rattus norvegicus], gi\|149042...	0.0	[2..388]	[4..390]

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Predicted Domain #1

Region A:
Residues: [1-388]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAAFISRVL RRVAQKSARR VLVASRNSSN DATFEIKKCD LYLLEEGPPV TTVLTRAEGL  60
   61 KYYRMMLTVR RMELKADQLY KQKFIRGFCH LCDGQEACCV GLEAGINPSD HVITSYRAHG 120
  121 VCYTRGLSVR SILAELTGRR GGCAKGKGGS MHMYTKNFYG GNGIVGAQGP LGAGIALACK 180
  181 YKGNDEICLT LYGDGAANQG QIAEAFNMAA LWKLPCVFIC ENNLYGMGTS TERAAASPDY 240
  241 YKRGNFIPGL KVDGMDVLCV REATKFAANY CRSGKGPILM ELQTYRYHGH SMSDPGVSYR 300
  301 TREEIQEVRS KRDPIIILQD RMVNSKLATV EELKEIGAEV RKEIDDAAQF ATTDPEPHLE 360
  361 ELGHHIYSSD SSFEVRGANP WIKFKSVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.30103
Match:	1ni4A
Description:	E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyruvate dehydrogenase activity	11.3856674722026	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	11.0549577473177	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	10.8180381281695	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	7.00951713446616	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	6.25236550086321	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.89064211833637	bayes_pls_golite062009
acetolactate synthase activity	4.51986503762195	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	3.8269109174531	bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity	3.00128844859152	bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity	3.00128844859152	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
transketolase activity	1.58421424158131	bayes_pls_golite062009
protein binding	0.992849906276347	bayes_pls_golite062009
binding	0.750068469698571	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.667418924427388	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: