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Protein Overview: MTMR8

General Information:
Name(s) found: MTMR8 [HGNC (HUGO)]
Description(s) found:
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  • gi|74751838|sp|Q96EF0.1|MTMR8_HUMAN RecName: Full=Myotubularin-related protein 8 [NCBI NR]
  • gi|57284029|emb|CAI43025.1| myotubularin related protein 8 [Homo sapiens] [NCBI NR]
  • gi|57162277|emb|CAI39934.1| myotubularin related protein 8 [Homo sapiens] [NCBI NR]
  • gi|21361759|ref|NP_060147.2| myotubularin related protein 8 [Homo sapiens] [NCBI NR]
  • gi|15214551|gb|AAH12399.1| Myotubularin related protein 8 [Homo sapiens] [NCBI NR]
  • gi|119625816|gb|EAX05411.1| myotubularin related protein 8, isoform CRA_b [Homo sapiens] [NCBI NR]
  • myotubularin related protein 8 [HGNC (HUGO)]
  • Myotubularin-related protein 8 OS=Homo sapiens GN=MTMR8 PE=1 SV=1 [Swiss-Prot]
  • Similar to hypothetical protein FLJ20126 [hmr_yeast5_DM3-1_pombe.fasta]
  • myotubularin related protein 8 [Homo sapiens]gi|15214551|gb|AAH12399.1| Myotubularin related protein 8 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Myotubularin related protein 8 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_017677) hypothetical protein FLJ20126 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • myotubularin related protein 8 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Myotubularin-related protein 8 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • myotubularin related protein 8, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Myotubularin related protein 8 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 MYOTUBULARIN RELATED PROTEIN 8 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MTMR8 Isoform 1 of Myotubularin-related protein 8 [human-ipi-250309-contam.fasta]
  • IPI:IPI00153020.1|SWISS-PROT:Q96EF0-1|ENSEMBL:ENSP00000363985|REFSEQ:NP_060147|H-INV:HIT000035804|VEGA:OTTHUMP00000023430 Tax_Id=9606 Gene_Symbol=MTMR8 Isoform 1 of Myotubularin-related protein 8 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MTMR8 Myotubularin-related protein 8 ENSG00000102043 IPI00002596 IPI00153020 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MTMR8 Myotubularin related protein 8 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • myotubularin-related protein 8 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q96EF0;Q5JT99;Q9NXP6; RecName: Full=Myotubularin-related protein 8; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Myotubularin-related protein 8 OS=Homo sapiens GN=MTMR8 [011711_HMR.fasta]
  • GeneSymbol=MTMR8 Synonyms=FLJ20126|FLJ60798 myotubularin-related protein 8 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00153020.1|SWISS-PROT:Q96EF0-1|ENSEMBL:ENSP00000363985|REFSEQ:NP_060147|VEGA:OTTHUMP00000023430 Tax_Id=9606 Gene_Symbol=MTMR8 Isoform 1 of Myotubularin-related protein 8 [ipi.HUMAN.20110912.fasta]
  • Myotubularin-related protein 8 GN=MTMR8 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHITVPKVE NVKLVDRYVS KKPANGILYL TATHLIYVEA SGAARKETWI ALHHIATVEK  60
   61 LPITSLGCPL TLRCKNFRVA HFVLDSDLVC HEVYISLLKL SQPALPEDLY AFSYNPKSSK 120
  121 EMRESGWKLI DPISDFGRMG IPNRNWTITD ANRNYEICST YPPEIVVPKS VTLGTVVGSS 180
  181 KFRSKERVPV LSYLYKENNA AICRCSQPLS GFYTRCVDDE LLLEAISQTN PGSQFMYVVD 240
  241 TRPKLNAMAN RAAGKGYENE DNYANIRFRF MGIENIHVMR SSLQKLLEVC ELKTPTMSEF 300
  301 LSGLESSGWL RHIKAIMDAG IFITKAVKVE KASVLVHCSD GWDRTAQVCS VASILLDPFY 360
  361 RTFKGLMILI EKEWISMGHK FSQRCGHLDG DSKEVSPIFT QFLDCIWQLM EQFPCAFEFN 420
  421 ENFLLEIHDH VFSCQFGNFL GNCQKDREDL RVYEKTHSVW PFLVQRKPDF RNPLYKGFTM 480
  481 YGVLNPSTVP YNIQFWCGMY NRFDKGLQPK QSMLESLLEI KKQRAMLETD VHELEKKLKV 540
  541 RDEPPEEICT CSQLGNILSQ HLGSPLTNPL GFMGINGDLN TLMENGTLSR EGGLRAQMDQ 600
  601 VKSQGADLHH NCCEIVGSLR AINISGDVGI SEAMGISGDM CTFEATGFSK DLGICGAMDI 660
  661 SEATGISGNL GISEARGFSG DMGILGDTGI SKASTKEADY SKHQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..540] PSI-BLAST 1000.0 Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
    2 View Details [541..704] PSI-BLAST 36.69897 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  7.03758345564381 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.82821455971597 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.83769298632658 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  4.03975183132282 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  2.60529675907066 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  2.05577133553311 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.95004535887255 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
    		•  1.72084618199574 bayes_pls_golite062009
  • hydrolase activity
    		•  1.5596484415033 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  1.51576958903553 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • kinase activity
    		•  0.541255358115631 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.532875179381704 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.359793029026564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • transferase activity
    		•  0.0332461821062801 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle