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Protein Overview: XIAP

General Information:
Name(s) found: XIAP [HGNC (HUGO)]
Description(s) found:
Found 39 descriptions.
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  • X-linked inhibitor of apoptosis [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 497 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA GFLYTGEGDT  60
   61 VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN SATQSTNSGI QNGQYKVENY 120
  121 LGSRDHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT 180
  181 PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE 240
  241 SDAVSSDRNF PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC 300
  301 FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP 360
  361 SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD 420
  421 SMQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK 480
  481 CPMCYTVITF KQKIFMS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] PSI-BLAST 24.39794 BIR domains of XIAP
    2 View Details [118..255] PSI-BLAST 34.221849 BIR domains of XIAP
    3 View Details [256..497] PSI-BLAST 17.09691 Cbl; N-terminal domain of cbl (N-cbl); CBL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.24291003560785 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • microtubule binding
    		•  1.03349057074077 bayes_pls_golite062009
  • tubulin binding
    		•  1.0137804715367 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.515008648709161 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0431703651486497 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0242766345667098 bayes_pls_golite062009
  • cofactor binding
    		•  0.0023150693787124 bayes_pls_golite062009
    2
    Term Confidence Notes
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.24291003560785 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • microtubule binding
    		•  1.03349057074077 bayes_pls_golite062009
  • tubulin binding
    		•  1.0137804715367 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.515008648709161 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.0431703651486497 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.0242766345667098 bayes_pls_golite062009
  • cofactor binding
    		•  0.0023150693787124 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.92323609459085 bayes_pls_golite062009
  • signal transducer activity
    		•  2.92323609459085 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.18707666182719 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.11378356087757 bayes_pls_golite062009
  • receptor binding
    		•  1.09099343809921 bayes_pls_golite062009
  • calcium ion binding
    		•  1.03474411638676 bayes_pls_golite062009
  • protein complex binding
    		•  0.89751976248113 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  0.551187568015903 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.36302486156653 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.353553274217716 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.352421112301971 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • structural molecule activity
    		•  0.234626449126289 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • actin binding
    		•  0.113835617777946 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle