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Protein Overview: PRKAG2

General Information:
Name(s) found: PRKAG2 [HGNC (HUGO)]
Description(s) found:
Found 33 descriptions.
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  • protein kinase, AMP-activated, gamma 2 non-catalytic subunit [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 569 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSAVMDTKK KKDVSSPGGS GGKKNASQKR RSLRVHIPDL SSFAMPLLDG DLEGSGKHSS  60
   61 RKVDSPFGPG SPSKGFFSRG PQPRPSSPMS APVRPKTSPG SPKTVFPFSY QESPPRSPRR 120
  121 MSFSGIFRSS SKESSPNSNP ATSPGGIRFF SRSRKTSGLS SSPSTPTQVT KQHTFPLESY 180
  181 KHEPERLENR IYASSSPPDT GQRFCPSSFQ SPTRPPLASP THYAPSKAAA LAAALGPAEA 240
  241 GMLEKLEFED EAVEDSESGV YMRFMRSHKC YDIVPTSSKL VVFDTTLQVK KAFFALVANG 300
  301 VRAAPLWESK KQSFVGMLTI TDFINILHRY YKSPMVQIYE LEEHKIETWR ELYLQETFKP 360
  361 LVNISPDASL FDAVYSLIKN KIHRLPVIDP ISGNALYILT HKRILKFLQL FMSDMPKPAF 420
  421 MKQNLDELGI GTYHNIAFIH PDTPIIKALN IFVERRISAL PVVDESGKVV DIYSKFDVIN 480
  481 LAAEKTYNNL DITVTQALQH RSQYFEGVVK CNKLEILETI VDRIVRAEVH RLVVVNEADS 540
  541 IVGIISLSDI LQALILTPAG AKQKETETE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] FFAS03 1.34 No description for 2j63A was found.
    2 View Details [168..226] deduced N/A No confident structure predictions are available.
    3 View Details [227..569] PSI-BLAST 48.69897 No description for 2v8qE was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphorylase kinase regulator activity
    		•  8.18623772563485 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  7.98159515020845 bayes_pls_golite062009
  • cAMP-dependent protein kinase inhibitor activity
    		•  7.37900747121671 bayes_pls_golite062009
  • cAMP-dependent protein kinase regulator activity
    		•  2.72879349930537 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.65736716029442 bayes_pls_golite062009
  • protein kinase activity
    		•  2.63659198898943 bayes_pls_golite062009
  • kinase activity
    		•  2.51764884377633 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.42131903112048 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.33489933634525 bayes_pls_golite062009
  • transporter activity
    		•  2.21524357108065 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.10896266379801 bayes_pls_golite062009
  • IMP dehydrogenase activity
    		•  2.02048863053452 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.83252375289841 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.76795590964783 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.68849505431325 bayes_pls_golite062009
  • transferase activity
    		•  1.67087201309072 bayes_pls_golite062009
  • binding
    		•  1.59201750877601 bayes_pls_golite062009
  • protein kinase binding
    		•  1.55645492554893 bayes_pls_golite062009
  • kinase binding
    		•  1.51987207051111 bayes_pls_golite062009
  • protein binding
    		•  1.3720766721692 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.819889205510396 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.756546410926039 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.64649571210819 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.5393211404321 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.49157430744145 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.44703917270274 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.43507333796993 bayes_pls_golite062009
  • channel activity
    		•  0.43507333796993 bayes_pls_golite062009
  • enzyme binding
    		•  0.36894766018324 bayes_pls_golite062009
  • ion channel activity
    		•  0.34353321539284 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.26231792801562 bayes_pls_golite062009
  • ADP binding
    		•  0.251209535806761 bayes_pls_golite062009
  • catalytic activity
    		•  0.181756622780318 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.1201202060055 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.0490362774640998 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.0446235642868298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle