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Protein Overview: GAK

General Information:
Name(s) found: GAK [HGNC (HUGO)]
Description(s) found:
Found 19 descriptions.
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  • cyclin G associated kinase [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1311 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV  60
   61 GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120
  121 LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180
  181 LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240
  241 GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300
  301 EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 360
  361 GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 420
  421 SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP 480
  481 HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 540
  541 MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 600
  601 VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA 660
  661 SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP 720
  721 PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS 780
  781 PPSSSADASR FLHTLDWQEE KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG 840
  841 QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 900
  901 CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP RGGPPAAADP 960
  961 FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGDLPGE1020
 1021 PSKMTASSSN PDLLGGWAAW TETAASAVAP TPATEGPLFS PGGQPAPCGS QASWTKSQNP1080
 1081 DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK1140
 1141 ACTQPRPNYA SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT1200
 1201 IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP1260
 1261 EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 83.0 No description for 2qnjA was found.
    2 View Details [377..737] PSI-BLAST 81.0 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
    3 View Details [738..822] deduced N/A No confident structure predictions are available.
    4 View Details [823..1152] PSI-BLAST 4.221849 No description for 1y0fA was found.
    5 View Details [1153..1311] PSI-BLAST 66.522879 NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  3.31810516049102 bayes_pls_golite062009
  • phosphatase activity
    		•  3.08137967812321 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.89012214818848 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.72498052648516 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.18218837175501 bayes_pls_golite062009
  • protein binding
    		•  2.12487185456363 bayes_pls_golite062009
  • binding
    		•  2.06015698112379 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05424732017237 bayes_pls_golite062009
  • DNA binding
    		•  1.95001230878269 bayes_pls_golite062009
  • protein kinase activity
    		•  1.3466747511896 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.10934693291056 bayes_pls_golite062009
  • kinase activity
    		•  1.07831702199434 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.0396675551487 bayes_pls_golite062009
  • phospholipid binding
    		•  0.74922416688674 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  0.743245088266464 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  0.743245088266464 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  0.631313032497835 bayes_pls_golite062009
  • lipid binding
    		•  0.480947190038912 bayes_pls_golite062009
  • transferase activity
    		•  0.351291836397779 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein binding
    		•  2.65982681685488 bayes_pls_golite062009
  • binding
    		•  2.63138872417193 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31739509739943 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.03886214021696 bayes_pls_golite062009
  • DNA binding
    		•  1.88444505115207 bayes_pls_golite062009
  • protein kinase activity
    		•  1.43288967182856 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.19936703248588 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.19546061220624 bayes_pls_golite062009
  • kinase activity
    		•  1.1645731811922 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • transferase activity
    		•  0.558702176210055 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.26936882742456 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.162050450070629 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle