| Protein: | GAK |
| Organism: | Homo sapiens |
| Length: | 1311 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAK.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1311] | [1..1311] |
|
|
0.0 | [1..1311] | [1..1311] |
|
|
0.0 | [1..1311] | [1..1305] |
|
|
0.0 | [1..1311] | [1..1311] |
|
|
0.0 | [1..1311] | [1..1305] |
|
Region A: Residues: [1-376] |
1 11 21 31 41 51
| | | | | |
1 MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV 60
61 GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120
121 LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180
181 LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240
241 GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300
301 EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 360
361 GLALAEYDQP YGGFLD
|
| Detection Method: |  |
| Confidence: | 83.0 |
| Match: | 2qnjA |
| Description: | No description for 2qnjA was found. |
|
Region A: Residues: [377-737] |
1 11 21 31 41 51
| | | | | |
1 ILRGGTERLF TNLKDTSSKV IQSVANYAKG DLDISYITSR IAVMSFPAEG VESALKNNIE 60
61 DVRLFLDSKH PGHYAVYNLS PRTYRPSRFH NRVSECGWAA RRAPHLHTLY NICRNMHAWL 120
121 RQDHKNVCVV HCMDGRAASA VAVCSFLCFC RLFSTAEAAV YMFSMKRCPP GIWPSHKRYI 180
181 EYMCDMVAEE PITPHSKPIL VRAVVMTPVP LFSKQRSGCR PFCEVYVGDE RVASTSQEYD 240
241 KMRDFKIEDG KAVIPLGVTV QGDVLIVIYH ARSTLGGRLQ AKMASMKMFQ IQFHTGFVPR 300
301 NATTVKFAKY DLDACDIQEK YPDLFQVNLE VEVEPRDRPS REAPPWENSS MRGLNPKILF 360
361 S
|
| Detection Method: | |
| Confidence: | 81.0 |
| Match: | 1d5rA |
| Description: | Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| phosphoprotein phosphatase activity | 3.31810516049102 | bayes_pls_golite062009 |
| phosphatase activity | 3.08137967812321 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.89012214818848 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activity | 2.72498052648516 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.18218837175501 | bayes_pls_golite062009 |
| protein binding | 2.12487185456363 | bayes_pls_golite062009 |
| binding | 2.06015698112379 | bayes_pls_golite062009 |
| nucleic acid binding | 2.05424732017237 | bayes_pls_golite062009 |
| DNA binding | 1.95001230878269 | bayes_pls_golite062009 |
| protein kinase activity | 1.3466747511896 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.10934693291056 | bayes_pls_golite062009 |
| kinase activity | 1.07831702199434 | bayes_pls_golite062009 |
| catalytic activity | 1.06283028154109 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.0396675551487 | bayes_pls_golite062009 |
| phospholipid binding | 0.74922416688674 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine phosphatase activity | 0.743245088266464 | bayes_pls_golite062009 |
| transmembrane receptor protein phosphatase activity | 0.743245088266464 | bayes_pls_golite062009 |
| protein tyrosine/serine/threonine phosphatase activity | 0.631313032497835 | bayes_pls_golite062009 |
| lipid binding | 0.480947190038912 | bayes_pls_golite062009 |
| transferase activity | 0.351291836397779 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.291525352733402 | bayes_pls_golite062009 |
| receptor activity | 0.191946218805025 | bayes_pls_golite062009 |
|
Region A: Residues: [738-822] |
1 11 21 31 41 51
| | | | | |
1 SREEQQDILS KFGKPELPRQ PGSTAQYDAG AGSPEAEPTD SDSPPSSSAD ASRFLHTLDW 60
61 QEEKEAETGA ENASSKESES ALMED
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [823-1152] |
1 11 21 31 41 51
| | | | | |
1 RDESEVSDEG GSPISSEGQE PRADPEPPGL AAGLVQQDLV FEVETPAVLP EPVPQEDGVD 60
61 LLGLHSEVGA GPAVPPQACK APSSNTDLLS CLLGPPEAAS QGPPEDLLSE DPLLLASPAP 120
121 PLSVQSTPRG GPPAAADPFG PLLPSSGNNS QPCSNPDLFG EFLNSDSVTV PPSFPSAHSA 180
181 PPPSCSADFL HLGDLPGEPS KMTASSSNPD LLGGWAAWTE TAASAVAPTP ATEGPLFSPG 240
241 GQPAPCGSQA SWTKSQNPDP FADLGDLSSG LQGSPAGFPP GGFIPKTATT PKGSSSWQTS 300
301 RPPAQGASWP PQAKPPPKAC TQPRPNYASN
|
| Detection Method: | |
| Confidence: | 4.221849 |
| Match: | 1y0fA |
| Description: | No description for 1y0fA was found. |
|
Region A: Residues: [1153-1311] |
1 11 21 31 41 51
| | | | | |
1 FSVIGAREER GVRAPSFAQK PKVSENDFED LLSNQGFSSR SDKKGPKTIA EMRKQDLAKD 60
61 TDPLKLKLLD WIEGKERNIR ALLSTLHTVL WDGESRWTPV GMADLVAPEQ VKKHYRRAVL 120
121 AVHPDKAAGQ PYEQHAKMIF MELNDAWSEF ENQGSRPLF
|
| Detection Method: | |
| Confidence: | 66.522879 |
| Match: | 1n4cA |
| Description: | NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein binding | 2.65982681685488 | bayes_pls_golite062009 |
| binding | 2.63138872417193 | bayes_pls_golite062009 |
| transcription regulator activity | 2.31739509739943 | bayes_pls_golite062009 |
| nucleic acid binding | 2.03886214021696 | bayes_pls_golite062009 |
| DNA binding | 1.88444505115207 | bayes_pls_golite062009 |
| protein kinase activity | 1.43288967182856 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.19936703248588 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.19546061220624 | bayes_pls_golite062009 |
| kinase activity | 1.1645731811922 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.671059013500415 | bayes_pls_golite062009 |
| transferase activity | 0.558702176210055 | bayes_pls_golite062009 |
| unfolded protein binding | 0.26936882742456 | bayes_pls_golite062009 |
| heat shock protein binding | 0.162050450070629 | bayes_pls_golite062009 |
| catalytic activity | 0.106988907594358 | bayes_pls_golite062009 |
