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Protein Overview: HADHB

General Information:
Name(s) found: HADHB [HGNC (HUGO)]
Description(s) found:
Found 28 descriptions.
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  • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTILTYPFKN LPTASKWALR FSIRPLSCSS QLRAAPAVQT KTKKTLAKPN IRNVVVVDGV  60
   61 RTPFLLSGTS YKDLMPHDLA RAALTGLLHR TSVPKEVVDY IIFGTVIQEV KTSNVAREAA 120
  121 LGAGFSDKTP AHTVTMACIS ANQAMTTGVG LIASGQCDVI VAGGVELMSD VPIRHSRKMR 180
  181 KLMLDLNKAK SMGQRLSLIS KFRFNFLAPE LPAVSEFSTS ETMGHSADRL AAAFAVSRLE 240
  241 QDEYALRSHS LAKKAQDEGL LSDVVPFKVP GKDTVTKDNG IRPSSLEQMA KLKPAFIKPY 300
  301 GTVTAANSSF LTDGASAMLI MAEEKALAMG YKPKAYLRDF MYVSQDPKDQ LLLGPTYATP 360
  361 KVLEKAGLTM NDIDAFEFHE AFSGQILANF KAMDSDWFAE NYMGRKTKVG LPPLEKFNNW 420
  421 GGSLSLGHPF GATGCRLVMA AANRLRKEGG QYGLVAACAA GGQGHAMIVE AYPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..474] PSI-BLAST 74.221849 Crystal structure of tt0182 from Thermus thermophilus HB8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetyl-CoA C-acyltransferase activity
    		•  8.08119341370748 bayes_pls_golite062009
  • long-chain-3-hydroxyacyl-CoA dehydrogenase activity
    		•  7.45371477074071 bayes_pls_golite062009
  • long-chain-enoyl-CoA hydratase activity
    		•  5.63866392580915 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.96408928512745 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  3.79121338118181 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] synthase activity
    		•  3.71249191203055 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  3.27532895419051 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.14957464437124 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.06879684191353 bayes_pls_golite062009
  • transferase activity
    		•  2.15834234036431 bayes_pls_golite062009
  • catalytic activity
    		•  2.14505178497871 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  1.87304265492939 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  1.77798276950874 bayes_pls_golite062009
  • acetyl-CoA C-acetyltransferase activity
    		•  1.50839304016514 bayes_pls_golite062009
  • C-acetyltransferase activity
    		•  1.19264084089277 bayes_pls_golite062009
  • hydroxymethylglutaryl-CoA synthase activity
    		•  1.16785899347652 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.6519546920419 bayes_pls_golite062009
  • binding
    		•  0.415385255550741 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.21899828831708 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle