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Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydroxymethylglutaryl-CoA synthase activity
Acc: GO:0004421
Aspect: Molecular Function
Desc: Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
Synonyms:
  • acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
  • 3-hydroxy-3-methylglutaryl CoA synthetase activity
  • 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
  • (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
  • HMG-CoA synthase activity
  • beta-hydroxy-beta-methylglutaryl-CoA synthase activity
  • hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
  • hydroxymethylglutaryl coenzyme A-condensing enzyme
  • 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
  • 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
  • 3-hydroxy-3-methylglutaryl-CoA synthase activity
  • (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
  • acetoacetyl coenzyme A transacetase activity
  • hydroxymethylglutaryl coenzyme A synthase activity
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004421 - hydroxymethylglutaryl-CoA synthase activity (interactive image map)
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