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Protein Overview: GABBR1

General Information:
Name(s) found: GABBR1 [HGNC (HUGO)]
Description(s) found:
Found 46 descriptions.
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  • gamma-aminobutyric acid (GABA) B receptor, 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 961 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLLLLAPL FLRPPGAGGA QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ VKAINFLPVD  60
   61 YEIEYVCRGE REVVGPKVRK CLANGSWTDM DTPSRCVRIC SKSYLTLENG KVFLTGGDLP 120
  121 ALDGARVDFR CDPDFHLVGS SRSICSQGQW STPKPHCQVN RTPHSERRAV YIGALFPMSG 180
  181 GWPGGQACQP AVEMALEDVN SRRDILPDYE LKLIHHDSKC DPGQATKYLY ELLYNDPIKI 240
  241 ILMPGCSSVS TLVAEAARMW NLIVLSYGSS SPALSNRQRF PTFFRTHPSA TLHNPTRVKL 300
  301 FEKWGWKKIA TIQQTTEVFT STLDDLEERV KEAGIEITFR QSFFSDPAVP VKNLKRQDAR 360
  361 IIVGLFYETE ARKVFCEVYK ERLFGKKYVW FLIGWYADNW FKIYDPSINC TVDEMTEAVE 420
  421 GHITTEIVML NPANTRSISN MTSQEFVEKL TKRLKRHPEE TGGFQEAPLA YDAIWALALA 480
  481 LNKTSGGGGR SGVRLEDFNY NNQTITDQIY RAMNSSSFEG VSGHVVFDAS GSRMAWTLIE 540
  541 QLQGGSYKKI GYYDSTKDDL SWSKTDKWIG GSPPADQTLV IKTFRFLSQK LFISVSVLSS 600
  601 LGIVLAVVCL SFNIYNSHVR YIQNSQPNLN NLTAVGCSLA LAAVFPLGLD GYHIGRNQFP 660
  661 FVCQARLWLL GLGFSLGYGS MFTKIWWVHT VFTKKEEKKE WRKTLEPWKL YATVGLLVGM 720
  721 DVLTLAIWQI VDPLHRTIET FAKEEPKEDI DVSILPQLEH CSSRKMNTWL GIFYGYKGLL 780
  781 LLLGIFLAYE TKSVSTEKIN DHRAVGMAIY NVAVLCLITA PVTMILSSQQ DAAFAFASLA 840
  841 IVFSSYITLV VLFVPKMRRL ITRGEWQSEA QDTMKTGSST NNNEEEKSRL LEKENRELEK 900
  901 IIAEKEERVS ELRHQLQSRQ QLRSRRHPPT PPEPSGGLPR GPPEPPDRLS CDGSRVHLLY 960
  961 K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] FFAS03 1.06 No description for 2ehfA was found.
    2 View Details [91..150] PSI-BLAST 4.30103 Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 trans conformer
    3 View Details [151..227] FFAS03 2.94 AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE
    4 View Details [228..642] PSI-BLAST 36.522879 No description for 2e4uA was found.
    5 View Details [643..797] MSA 6.479975 View MSA. No confident structure predictions are available.
    6 View Details [798..961] PSI-BLAST 4.69897 N-methyl-D-aspartate receptor subunit 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • olfactory receptor activity
    		•  9.71360485861748 bayes_pls_golite062009
  • peptide antigen binding
    		•  9.47162360140341 bayes_pls_golite062009
  • GABA-B receptor activity
    		•  7.35033638238525 bayes_pls_golite062009
  • GABA receptor activity
    		•  6.90608993864808 bayes_pls_golite062009
  • antigen binding
    		•  5.58808732806538 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.35860459468361 bayes_pls_golite062009
  • receptor activity
    		•  4.20713357041878 bayes_pls_golite062009
  • cell surface binding
    		•  3.55050906717351 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.3267793934617 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.26442969564963 bayes_pls_golite062009
  • signal transducer activity
    		•  3.26442969564963 bayes_pls_golite062009
  • glutamate receptor activity
    		•  3.14418732579293 bayes_pls_golite062009
  • protein binding
    		•  3.02592228806142 bayes_pls_golite062009
  • interleukin-2 binding
    		•  2.71513067590075 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  2.55335439762658 bayes_pls_golite062009
  • complement binding
    		•  2.34774745677343 bayes_pls_golite062009
  • binding
    		•  2.33940742543305 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  2.32048018940275 bayes_pls_golite062009
  • cytokine binding
    		•  2.30130828185426 bayes_pls_golite062009
  • glycoprotein binding
    		•  2.22789099360417 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.10514365820386 bayes_pls_golite062009
  • lipoprotein lipase activator activity
    		•  2.06465193625541 bayes_pls_golite062009
  • growth factor binding
    		•  1.93618687932038 bayes_pls_golite062009
  • complement component C3b binding
    		•  1.88857759736005 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.47508652223701 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.4147190450456 bayes_pls_golite062009
  • peptide binding
    		•  1.27282764780447 bayes_pls_golite062009
  • heparin binding
    		•  1.23765110858669 bayes_pls_golite062009
  • pattern binding
    		•  1.12569810277318 bayes_pls_golite062009
  • opsonin binding
    		•  1.0527649340829 bayes_pls_golite062009
  • catalytic activity
    		•  0.252597265474331 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.167507966251191 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.15682585610523 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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