YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: GABBR1
Organism: Homo sapiens
Length: 961 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GABBR1.

Description E-value Query
Range
Subject
Range
gi|4063892 - gi|4063892|gb|AAC98508.1| GABA-B1a receptor [Homo sapiens]
0.0 [16..961] [16..961]
gi|76651014 - gi|76651014|ref|XP_874688.1| PREDICTED: similar to GABA-B receptor isoform 2 [Bos taurus]
0.0 [16..961] [16..961]
gi|77404238, gi|... - gi|77404238|ref|NP_112290.2| gamma-aminobutyric acid (GABA) B receptor 1 [Rattus norvegicus], gi|462...
0.0 [16..961] [15..960]
GABR1_MOUSE - Gamma-aminobutyric acid type B receptor subunit 1 OS=Mus musculus GN=Gabbr1 PE=1 SV=1
0.0 [16..961] [15..960]
gi|109070167 - gi|109070167|ref|XP_001097474.1| PREDICTED: similar to gamma-aminobutyric acid (GABA) B receptor 1 i...
0.0 [73..961] [202..1090]

Back

Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLLLLAPL FLRPPGAGGA QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ VKAINFLPVD  60
   61 YEIEYVCRGE REVVGPKVRK CLANGSWTDM 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 2ehfA
Description: No description for 2ehfA was found.

Predicted Domain #2
Region A:
Residues: [91-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTPSRCVRIC SKSYLTLENG KVFLTGGDLP ALDGARVDFR CDPDFHLVGS SRSICSQGQW  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1srzA
Description: Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 trans conformer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
olfactory receptor activity 9.71360485861748 bayes_pls_golite062009
peptide antigen binding 9.47162360140341 bayes_pls_golite062009
GABA-B receptor activity 7.35033638238525 bayes_pls_golite062009
GABA receptor activity 6.90608993864808 bayes_pls_golite062009
antigen binding 5.58808732806538 bayes_pls_golite062009
transmembrane receptor activity 4.35860459468361 bayes_pls_golite062009
receptor activity 4.20713357041878 bayes_pls_golite062009
cell surface binding 3.55050906717351 bayes_pls_golite062009
G-protein coupled receptor activity 3.3267793934617 bayes_pls_golite062009
molecular transducer activity 3.26442969564963 bayes_pls_golite062009
signal transducer activity 3.26442969564963 bayes_pls_golite062009
glutamate receptor activity 3.14418732579293 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
interleukin-2 binding 2.71513067590075 bayes_pls_golite062009
interleukin-2 receptor activity 2.55335439762658 bayes_pls_golite062009
complement binding 2.34774745677343 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
eukaryotic cell surface binding 2.32048018940275 bayes_pls_golite062009
cytokine binding 2.30130828185426 bayes_pls_golite062009
glycoprotein binding 2.22789099360417 bayes_pls_golite062009
cytokine receptor activity 2.10514365820386 bayes_pls_golite062009
lipoprotein lipase activator activity 2.06465193625541 bayes_pls_golite062009
growth factor binding 1.93618687932038 bayes_pls_golite062009
complement component C3b binding 1.88857759736005 bayes_pls_golite062009
glycosaminoglycan binding 1.47508652223701 bayes_pls_golite062009
polysaccharide binding 1.4147190450456 bayes_pls_golite062009
peptide binding 1.27282764780447 bayes_pls_golite062009
heparin binding 1.23765110858669 bayes_pls_golite062009
pattern binding 1.12569810277318 bayes_pls_golite062009
opsonin binding 1.0527649340829 bayes_pls_golite062009
catalytic activity 0.252597265474331 bayes_pls_golite062009
enzyme inhibitor activity 0.167507966251191 bayes_pls_golite062009
carbohydrate binding 0.15682585610523 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [151-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STPKPHCQVN RTPHSERRAV YIGALFPMSG GWPGGQACQP AVEMALEDVN SRRDILPDYE  60
   61 LKLIHHDSKC DPGQATK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.94
Match: 1peaA
Description: AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [228-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLYELLYNDP IKIILMPGCS SVSTLVAEAA RMWNLIVLSY GSSSPALSNR QRFPTFFRTH  60
   61 PSATLHNPTR VKLFEKWGWK KIATIQQTTE VFTSTLDDLE ERVKEAGIEI TFRQSFFSDP 120
  121 AVPVKNLKRQ DARIIVGLFY ETEARKVFCE VYKERLFGKK YVWFLIGWYA DNWFKIYDPS 180
  181 INCTVDEMTE AVEGHITTEI VMLNPANTRS ISNMTSQEFV EKLTKRLKRH PEETGGFQEA 240
  241 PLAYDAIWAL ALALNKTSGG GGRSGVRLED FNYNNQTITD QIYRAMNSSS FEGVSGHVVF 300
  301 DASGSRMAWT LIEQLQGGSY KKIGYYDSTK DDLSWSKTDK WIGGSPPADQ TLVIKTFRFL 360
  361 SQKLFISVSV LSSLGIVLAV VCLSFNIYNS HVRYIQNSQP NLNNLTAVGC SLALA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 2e4uA
Description: No description for 2e4uA was found.

Predicted Domain #5
Region A:
Residues: [643-797]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVFPLGLDGY HIGRNQFPFV CQARLWLLGL GFSLGYGSMF TKIWWVHTVF TKKEEKKEWR  60
   61 KTLEPWKLYA TVGLLVGMDV LTLAIWQIVD PLHRTIETFA KEEPKEDIDV SILPQLEHCS 120
  121 SRKMNTWLGI FYGYKGLLLL LGIFLAYETK SVSTE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [798-961]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KINDHRAVGM AIYNVAVLCL ITAPVTMILS SQQDAAFAFA SLAIVFSSYI TLVVLFVPKM  60
   61 RRLITRGEWQ SEAQDTMKTG SSTNNNEEEK SRLLEKENRE LEKIIAEKEE RVSELRHQLQ 120
  121 SRQQLRSRRH PPTPPEPSGG LPRGPPEPPD RLSCDGSRVH LLYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1pb7A
Description: N-methyl-D-aspartate receptor subunit 1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle