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Protein Overview: MBD3

General Information:
Name(s) found: MBD3 [HGNC (HUGO)]
Description(s) found:
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  • gi|50400820|sp|O95983.1|MBD3_HUMAN RecName: Full=Methyl-CpG-binding domain protein 3; AltName: Full=Methyl-CpG-binding protein MBD3 [NCBI NR]
  • gi|4505119|ref|NP_003917.1| methyl-CpG binding domain protein 3 [Homo sapiens] [NCBI NR]
  • gi|3850564|gb|AAC72104.1| methyl-CpG binding protein MBD3 [Homo sapiens] [NCBI NR]
  • gi|3800803|gb|AAC68876.1| methyl-CpG binding domain-containing protein MBD3 [Homo sapiens] [NCBI NR]
  • gi|158255200|dbj|BAF83571.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119589887|gb|EAW69481.1| methyl-CpG binding domain protein 3, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119589884|gb|EAW69478.1| methyl-CpG binding domain protein 3, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119589883|gb|EAW69477.1| methyl-CpG binding domain protein 3, isoform CRA_a [Homo sapiens] [NCBI NR]
  • methyl-CpG binding domain protein 3 [HGNC (HUGO)]
  • Methyl-CpG-binding domain protein 3 OS=Homo sapiens GN=MBD3 PE=1 SV=1 [Swiss-Prot]
  • Methyl-CpG binding protein MBD3 [hmr_yeast5_DM3-1_pombe.fasta]
  • PREDICTED: similar to methyl-CpG binding domain protein 3 [Pan troglodytes]gi|4505119|ref|NP_003917.1| methyl-CpG binding domain protein 3 [Homo sapiens]gi|3800803|gb|AAC68876.1| methyl-CpG binding domain-containing protein MBD3 [Homo sapiens]gi|385056 [nrdb_11152004_Chlamydomonas]
  • Methyl-CpG-binding domain protein 3 (Methyl-CpG binding protein MBD3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Methyl-CpG-binding domain protein 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003926) methyl-CpG binding domain protein 3 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • methyl-CpG binding domain protein 3 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • methyl-CpG binding domain protein 3, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • methyl-CpG binding protein MBD3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • methyl-CpG binding domain-containing protein MBD3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Methyl-CpG-binding domain protein 3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF METHYL-CPG BINDING PROTEIN 3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MBD3 Isoform 1 of Methyl-CpG-binding domain protein 3 [human-ipi-250309-contam.fasta]
  • IPI:IPI00439194.1|SWISS-PROT:O95983-1|TREMBL:A8K4B7|ENSEMBL:ENSP00000156825;ENSP00000347886|REFSEQ:NP_003917|VEGA:OTTHUMP00000077517;OTTHUMP00000077518 Tax_Id=9606 Gene_Symbol=MBD3 Isoform 1 of Methyl-CpG-binding domain protein 3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MBD3 Isoform 1 of Methyl-CpG-binding domain protein 3 ENSG00000071655 IPI00439194 IPI00382954 IPI00439195 [drosphohumanreversed.fasta]
  • methyl-CpG-binding domain protein 3 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O95983;A8K4B7;Q6PIL9;Q6PJZ9;Q86XF4; RecName: Full=Methyl-CpG-binding domain protein 3; AltName: Full=Methyl-CpG-binding protein MBD3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Methyl-CpG-binding domain protein 3 OS=Homo sapiens GN=MBD3 [011711_HMR.fasta]
  • IPI:IPI00439194.1|SWISS-PROT:O95983-1|ENSEMBL:ENSP00000156825;ENSP00000347886|REFSEQ:NP_003917|VEGA:OTTHUMP00000077517;OTTHUMP00000077518 Tax_Id=9606 Gene_Symbol=MBD3 Isoform 1 of Methyl-CpG-binding domain protein 3 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=MBD3 Synonyms=- methyl-CpG-binding domain protein 3 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00439194.1|SWISS-PROT:O95983-1|ENSEMBL:ENSP00000156825|REFSEQ:NP_003917 Tax_Id=9606 Gene_Symbol=MBD3 Isoform 1 of Methyl-CpG-binding domain protein 3 [ipi.HUMAN.20110912.fasta]
  • Methyl-CpG-binding domain protein 3 GN=MBD3 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 291 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS  60
   61 TFDFRTGKML MSKMNKSRQR VRYDSSNQVK GKPDLNTALP VRQTASIFKQ PVTKITNHPS 120
  121 NKVKSDPQKA VDQPRQLFWE KKLSGLNAFD IAEELVKTMD LPKGLQGVGP GCTDETLLSA 180
  181 IASALHTSTM PITGQLSAAV EKNPGVWLNT TQPLCKAFMV TDEDIRKQEE LVQQVRKRLE 240
  241 EALMADMLAH VEELARDGEA PLDKACAEDD DEEDEEEEEE EPDPDPEMEH V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 26.522879 Methylation-dependent transcriptional repressor MBD1/PCM1
    2 View Details [79..196] MSA 1.032983 View MSA. No confident structure predictions are available.
    3 View Details [197..291] MSA 4.032988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyl-CpG binding
    		•  4.54540676267869 bayes_pls_golite062009
  • DNA binding
    		•  4.42562920230852 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.33195028920652 bayes_pls_golite062009
  • double-stranded methylated DNA binding
    		•  4.13704647712557 bayes_pls_golite062009
  • unmethylated CpG binding
    		•  4.11290155206252 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.19559870959168 bayes_pls_golite062009
  • binding
    		•  3.0325775548747 bayes_pls_golite062009
  • chromatin binding
    		•  2.99247237408109 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.97633361410339 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.70291730403476 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.42722575436746 bayes_pls_golite062009
  • transcription factor activity
    		•  2.27540830787547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.67549684739333 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.53919976183276 bayes_pls_golite062009
  • protein binding
    		•  1.48651016577672 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  1.40804604506756 bayes_pls_golite062009
  • four-way junction DNA binding
    		•  1.09532938985367 bayes_pls_golite062009
  • nucleotide binding
    		•  0.409742306544047 bayes_pls_golite062009
  • RNA binding
    		•  0.33612198087066 bayes_pls_golite062009
  • mRNA binding
    		•  0.28477406293958 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle