YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: BIRC5

General Information:
Name(s) found: BIRC5 [HGNC (HUGO)]
Description(s) found:
SHOW ONLY BEST
  • gi|6647543|sp|O15392|BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) [NCBI NR]
  • gi|54781377|gb|AAV40840.1| baculoviral IAP repeat-containing 5 (survivin) [Homo sapiens] [NCBI NR]
  • gi|4959079|gb|AAD34226.1|AF077350_1 inhibitor of apoptosis homolog [Homo sapiens] [NCBI NR]
  • ref|NP_001159.1| baculoviral IAP repeat-containing protein 5 [Homo sapiens] [NCBI NR]
  • gi|41389061|gb|AAH65497.1| Baculoviral IAP repeat-containing 5 [Homo sapiens] [NCBI NR]
  • gi|2315863|gb|AAC51660.1| apoptosis inhibitor survivin [Homo sapiens] [NCBI NR]
  • gi|21707887|gb|AAH34148.1| Baculoviral IAP repeat-containing 5 [Homo sapiens] [NCBI NR]
  • gi|189065135|dbj|BAG34858.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|160285868|pdb|2QFA|A Chain A, Crystal Structure Of A Survivin-Borealin-Incenp Core Complex [NCBI NR]
  • gi|14250534|gb|AAH08718.1| Baculoviral IAP repeat-containing 5 [Homo sapiens] [NCBI NR]
  • gi|13096774|pdb|1E31|B Chain B, Survivin Dimer H. Sapiens [NCBI NR]
  • gi|13096773|pdb|1E31|A Chain A, Survivin Dimer H. Sapiens [NCBI NR]
  • gi|119609920|gb|EAW89514.1| baculoviral IAP repeat-containing 5 (survivin), isoform CRA_d [Homo sapiens] [NCBI NR]
  • baculoviral IAP repeat-containing 5 (survivin) [HGNC (HUGO)]
  • Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens GN=BIRC5 PE=1 SV=3 [Swiss-Prot]
  • (O15392) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) [Swiss-Prot]
  • Splice isoform Alpha of O15392 [hmr_yeast5_DM3-1_pombe.fasta]
  • baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin [HMR_022704.fasta]
  • baculoviral IAP repeat-containing 5 (survivin) [Homo sapiens]gi|4502145|ref|NP_001159.1| baculoviral IAP repeat-containing protein 5 [Homo sapiens]gi|2315863|gb|AAC51660.1| apoptosis inhibitor survivin [Homo sapiens]gi|41389061|gb|AAH65497.1| Baculovir [nrdb_11152004_Chlamydomonas]
  • Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Alpha of Baculoviral IAP repeat-containing protein 5 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001168) baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • inhibitor of apoptosis homolog [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin [Homo sapiens] [HumanGallus06162005.fasta]
  • Baculoviral IAP repeat-containing 5 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Crystal Structure Of A Survivin-Borealin-Incenp Core Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Survivin Dimer H. Sapiens [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Survivin Dimer H. Sapiens [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • baculoviral IAP repeat-containing 5 (survivin), isoform CRA_d [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • baculoviral IAP repeat-containing 5 (survivin) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • apoptosis inhibitor survivin [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Baculoviral IAP repeat-containing 5 (survivin) [Homo sapiens] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Baculoviral IAP repeat-containing protein 5 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=BIRC5 Isoform 1 of Baculoviral IAP repeat-containing protein 5 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Baculoviral IAP repeat-containing protein 5 GN=BIRC5 [Doctor+uniprot-HUMAN-120911.fasta]
  • Baculoviral IAP repeat-containing 5 OS=Homo sapiens GN=BIRC5 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 142 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC  60
   61 FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120
  121 KKEFEETAKK VRRAIEQLAA MD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. BIRC5 gi|112491310

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 43.522879 Anti-apoptotic protein survivin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule binding
    		•  4.86535736353162 bayes_pls_golite062009
  • tubulin binding
    		•  4.84666941238345 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.62581200332375 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  3.56747355861961 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  3.46258520447799 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  3.37793799691411 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • binding
    		•  2.82472291325192 bayes_pls_golite062009
  • caspase regulator activity
    		•  2.78624473612776 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  2.43952820346737 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.18464294370673 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.6845701774335 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.59597592754555 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.204341973906209 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle