YRC Public Data Repository - Protein Structure Prediction

Protein:	BIRC5
Organism:	Homo sapiens
Length:	142 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIRC5.

Description	E-value	Query Range	Subject Range
gi\|67969107 - gi\|67969107\|dbj\|BAE00908.1\| unnamed protein product [Macaca fascicularis]	179.0	[0..1]	[142..1]
BIRC5_MOUSE - Baculoviral IAP repeat-containing protein 5 OS=Mus musculus GN=Birc5 PE=1 SV=1	173.0	[0..1]	[140..1]
BIRC5_RAT - Baculoviral IAP repeat-containing protein 5 OS=Rattus norvegicus GN=Birc5 PE=2 SV=1	173.0	[0..1]	[141..1]
gi\|60830680, gi\|... - gi\|60830680\|gb\|AAX36940.1\| baculoviral IAP repeat-containing 5 [synthetic construct], gi\|60654171\|gb...	173.0	[0..1]	[142..1]
gi\|59859878, gi\|... - gi\|59859878\|ref\|NP_001159.2\| baculoviral IAP repeat-containing protein 5 isoform 1 [Homo sapiens], g...	173.0	[0..1]	[142..1]
BIRC5_CANFA, BIR... - (Q8I009) Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin), (Q8I009) Baculo...	172.0	[0..1]	[142..1]
gi\|114670699, gi... - gi\|114670699\|ref\|XP_001156931.1\| PREDICTED: baculoviral IAP repeat-containing protein 5 isoform 6 [P...	172.0	[0..1]	[142..1]
gi\|109118487 - gi\|109118487\|ref\|XP_001108164.1\| PREDICTED: similar to baculoviral IAP repeat-containing protein 5 i...	171.0	[0..1]	[142..1]

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Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC  60
   61 FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120
  121 KKEFEETAKK VRRAIEQLAA MD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.522879
Match:	1e31A
Description:	Anti-apoptotic protein survivin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
microtubule binding	4.86535736353162	bayes_pls_golite062009
tubulin binding	4.84666941238345	bayes_pls_golite062009
cytoskeletal protein binding	3.62581200332375	bayes_pls_golite062009
endopeptidase inhibitor activity	3.56747355861961	bayes_pls_golite062009
peptidase inhibitor activity	3.46258520447799	bayes_pls_golite062009
caspase inhibitor activity	3.37793799691411	bayes_pls_golite062009
protein binding	2.82801305666365	bayes_pls_golite062009
binding	2.82472291325192	bayes_pls_golite062009
caspase regulator activity	2.78624473612776	bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity	2.43952820346737	bayes_pls_golite062009
enzyme inhibitor activity	1.18464294370673	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.6845701774335	bayes_pls_golite062009
small conjugating protein ligase activity	0.59597592754555	bayes_pls_golite062009
protein dimerization activity	0.204341973906209	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: