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Protein Overview: CFLAR

General Information:
Name(s) found: CFLAR [HGNC (HUGO)]
Description(s) found:
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  • gi|62988903|gb|AAY24290.1| unknown [Homo sapiens] [NCBI NR]
  • gi|3133281|gb|AAC16439.1| Usurpin-alpha [Homo sapiens] [NCBI NR]
  • gi|30582341|gb|AAP35397.1| CASP8 and FADD-like apoptosis regulator [Homo sapiens] [NCBI NR]
  • gi|2827290|gb|AAB99790.1| I-FLICE [Homo sapiens] [NCBI NR]
  • gi|2583142|gb|AAB82648.1| MRIT-alpha-1 [Homo sapiens] [NCBI NR]
  • gi|2429158|gb|AAB70911.1| FLAME-1-gamma [Homo sapiens] [NCBI NR]
  • gi|2281476|gb|AAB64110.1| Casper [Homo sapiens] [NCBI NR]
  • gi|2253679|gb|AAC51622.1| FLICE-like inhibitory protein long form [Homo sapiens] [NCBI NR]
  • gi|189054883|dbj|BAG37645.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|187608577|ref|NP_001120655.1| CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] [NCBI NR]
  • gi|187608571|ref|NP_003870.4| CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] [NCBI NR]
  • gi|158260849|dbj|BAF82602.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|12804401|gb|AAH01602.1| CASP8 and FADD-like apoptosis regulator [Homo sapiens] [NCBI NR]
  • gi|12643547|sp|O15519.1|CFLAR_HUMAN RecName: Full=CASP8 and FADD-like apoptosis regulator; AltName: Full=Cellular FLICE-like inhibitory protein; Short=c-FLIP; AltName: Full=Caspase-eight-related protein; Short=Casper; AltName: Full=Caspase-like apoptosis [NCBI NR]
  • gi|119590651|gb|EAW70245.1| CASP8 and FADD-like apoptosis regulator, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119590649|gb|EAW70243.1| CASP8 and FADD-like apoptosis regulator, isoform CRA_c [Homo sapiens] [NCBI NR]
  • gi|119590643|gb|EAW70237.1| CASP8 and FADD-like apoptosis regulator, isoform CRA_c [Homo sapiens] [NCBI NR]
  • CASP8 and FADD-like apoptosis regulator [HGNC (HUGO)]
  • (O15519) CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) [Swiss-Prot]
  • CASP8 and FADD-like apoptosis regulator OS=Homo sapiens GN=CFLAR PE=1 SV=1 [Swiss-Prot]
  • Splice isoform 1 of O15519 [hmr_yeast5_DM3-1_pombe.fasta]
  • CASP8 and FADD-like apoptosis regulator [Homo sapiens]gi|12804401|gb|AAH01602.1| CASP8 and FADD-like apoptosis regulator [Homo sapiens]gi|2253679|gb|AAC51622.1| FLICE-like inhibitory protein long form [Homo sapiens]gi|3133281|gb|AAC16439.1| Usurpin-alp [nrdb_11152004_Chlamydomonas]
  • CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (C [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of CASP8 and FADD-like apoptosis regulator precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • FLICE-like inhibitory protein long form [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • CASP8 and FADD-like apoptosis regulator, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • CASP8 and FADD-like apoptosis regulator [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unknown [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Usurpin-alpha [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • I-FLICE [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MRIT-alpha-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FLAME-1-gamma [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Casper [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of CASP8 and FADD-like apoptosis regulator precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF CASP8 AND FADD-LIKE APOPTOSIS REGULATOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=CASP8 and FADD-like apoptosis regulator; AltName: Full=Cellular FLICE-like inhibitory protein; Short=c-FLIP; AltName: Full=Caspase-eight-related protein; Short=Casper; AltName: Full=Caspase-like apoptosis regulatory protein; Short=CLARP; Alt [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosis regulator [human-ipi-250309-contam.fasta]
  • IPI:IPI00007287.1|SWISS-PROT:O15519-1|TREMBL:Q53TS6|ENSEMBL:ENSP00000312455;ENSP00000399420|REFSEQ:NP_001120655;NP_003870|H-INV:HIT000030509|VEGA:OTTHUMP00000163715;OTTHUMP00000206480 Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosi [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosis regulator precursor ENSG00000003402 IPI00007287 IPI00394836 IPI00216956 IPI00414806 IPI00219241 IPI00216962 IPI00219239 IPI00556163 IPI00219242 IPI00219243 IPI00216957 IPI00216958 IPI00216959 IPI00216960 IPI00216963 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosis regulator precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • O15519;B7Z9F9;O14673;O14674;O14675;O15137;O15138;O15356;O15510;O43618;O43619;O43620;O60458;O60459;Q54AF1;Q96TE4;Q9UEW1; RecName: Full=CASP8 and FADD-like apoptosis regulator; AltName: Full=Cellular FLICE-like inhibitory protein; AltName: Full=Caspase-eight-related protein; AltName: Full=Caspase-like apoptosis regulatory protein; AltName: Full=MACH-related inducer of toxicity; AltName: Full=Caspase homolog; AltName: Full=Inhibitor of FLICE; AltName: Full=FADD-like antiapoptotic molecule 1; AltName: Full=Usurpin; Contains: RecName: Full=CASP8 and FADD-like apoptosis regulator subunit p43; Contains: RecName: Full=CASP8 and FADD-like apoptosis regulator subunit p12; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of CASP8 and FADD-like apoptosis regulator OS=Homo sapiens GN=CFLAR [011711_HMR.fasta]
  • IPI:IPI00007287.1|SWISS-PROT:O15519-1|TREMBL:Q53TS6|ENSEMBL:ENSP00000312455;ENSP00000399420|REFSEQ:NP_001120655;NP_003870|H-INV:HIT000030509|VEGA:OTTHUMP00000163715;OTTHUMP00000206480 Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosis regulator [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=CFLAR Synonyms=CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS CASP8 and FADD-like apoptosis regulator isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00007287.1|SWISS-PROT:O15519-1|ENSEMBL:ENSP00000312455;ENSP00000399420|REFSEQ:NP_001120655;NP_003870|H-INV:HIT000030509|VEGA:OTTHUMP00000163715;OTTHUMP00000206480 Tax_Id=9606 Gene_Symbol=CFLAR Isoform 1 of CASP8 and FADD-like apoptosis regulator [ipi.HUMAN.20110912.fasta]
  • CASP8 and FADD-like apoptosis regulator GN=CFLAR [Doctor+uniprot-HUMAN-120911.fasta]
  • CASP8 and FADD-like apoptosis regulator, isoform CRA_c OS=Homo sapiens GN=CFLAR PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 480 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY  60
   61 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 120
  121 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 180
  181 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 240
  241 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 300
  301 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 360
  361 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 420
  421 SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT 480
  481

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 34.0 Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
    2 View Details [195..480] PSI-BLAST 76.045757 Apopain (caspase-3, cpp32)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.07648676430905 bayes_pls_golite062009
  • protein binding
    		•  2.96725373477762 bayes_pls_golite062009
  • binding
    		•  2.91261616137775 bayes_pls_golite062009
  • hydrolase activity
    		•  2.68442077801437 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.49877323830478 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.37850336421322 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.92144732327593 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.82979469421101 bayes_pls_golite062009
  • apoptotic protease activator activity
    		•  1.68590402463614 bayes_pls_golite062009
  • catalytic activity
    		•  1.03907950272772 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0737251792690711 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle